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Literature DB >> 32462464

Domino ring opening and selective O/S-alkylation of cyclic ethers and thioethers.

Manickam Bakthadoss¹, Vishal Agarwal², Thirupathi Reddy Tadiparthi², Mushaf Mohammad².

Abstract

Chemoselective domino ring opening and selective O/S-alkylation of ethers/thioethers over enol C/O alkylation has been observed. Various 2-aryl chromanones/thiochromanones with alkyl/allyl bromides were smoothly converted into the corresponding highly functionalized ethers and thioethers in excellent yields with high selectivity. An unusual, chemoselective domino ring opening and selective ether/thioether O/S-alkylation over. An unusual, chemoselective domino ring opening and selective ether/thioether O/S alkylation over enol C/O alkylation has been observed.

Entities: Chemical

Keywords: 2-Aryl chromanones; 2-Aryl thiochromanones; Chalcone; Domino ring opening; O/S-alkylation

Mesh：
Ethers, Cyclic

Substances：
Ethers, Cyclic

Year: 2020 PMID： 32462464 DOI： 10.1007/s11030-020-10105-2

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943

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References

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Domino ring opening and selective O/S-alkylation of cyclic ethers and thioethers.

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4. Highly regio- and diastereo-selective synthesis of novel tri- and tetra-cyclic perhydroquinoline architectures via an intramolecular [3 + 2] cycloaddition reaction.

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