Literature DB >> 12825923

Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents.

Srinivas K Kumar1, Erin Hager, Catherine Pettit, Hallur Gurulingappa, Nancy E Davidson, Saeed R Khan.   

Abstract

A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.

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Year:  2003        PMID： 12825923     DOI： 10.1021/jm030213+

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  38 in total

1.  Stabilization of p53 in influenza A virus-infected cells is associated with compromised MDM2-mediated ubiquitination of p53.

Authors:  Xiaodu Wang; Xufang Deng; Wenjun Yan; Zixiang Zhu; Yang Shen; Yafeng Qiu; Zixue Shi; Donghua Shao; Jianchao Wei; Xianzhu Xia; Zhiyong Ma
Journal:  J Biol Chem       Date:  2012-04-03       Impact factor: 5.157

Review 2.  Chalcone: A Privileged Structure in Medicinal Chemistry.

Authors:  Chunlin Zhuang; Wen Zhang; Chunquan Sheng; Wannian Zhang; Chengguo Xing; Zhenyuan Miao
Journal:  Chem Rev       Date:  2017-05-10       Impact factor: 60.622

3.  Anoikis triggers Mdm2-dependent p53 degradation.

Authors:  Abhijit Ghosh; Tina Chunyuan Chen; Yvonne L Kapila
Journal:  Mol Cell Biochem       Date:  2010-06-26       Impact factor: 3.396

4.  The winding road of the uvaretin class of natural products: from total synthesis to bioactive agent discovery.

Authors:  Johnathan Dallman; Ashabha Lansakara; Thi Nguyen; Chamitha Weeramange; Wasundara Hulangamuwa; Ryan J Rafferty
Journal:  Medchemcomm       Date:  2019-06-11       Impact factor: 3.597

5.  Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors.

Authors:  Sultan Nacak Baytas; Nazan Inceler; Akin Yilmaz; Abdurrahman Olgac; Sevda Menevse; Erden Banoglu; Ernest Hamel; Roberta Bortolozzi; Giampietro Viola
Journal:  Bioorg Med Chem       Date:  2014-04-20       Impact factor: 3.641

6.  A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.

Authors:  Yali Kong; Kan Wang; Michael C Edler; Ernest Hamel; Susan L Mooberry; Mikell A Paige; Milton L Brown
Journal:  Bioorg Med Chem       Date:  2009-11-10       Impact factor: 3.641

Review 7.  Molecular targeted approaches to cancer therapy and prevention using chalcones.

Authors:  Danielle D Jandial; Christopher A Blair; Saiyang Zhang; Lauren S Krill; Yan-Bing Zhang; Xiaolin Zi
Journal:  Curr Cancer Drug Targets       Date:  2014       Impact factor: 3.428

8.  (E)-3-(4-Fluoro-phen-yl)-1-[4-(methyl-sulfan-yl)phen-yl]prop-2-en-1-one.

Authors:  N Anuradha; A Thiruvalluvar; M Mahalinga; R J Butcher
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-10-15

9.  Synthesis and activity of a new series of (Z)-3-phenyl-2-benzoylpropenoic acid derivatives as aldose reductase inhibitors.

Authors:  Shao-Jie Wang; Ju-Fang Yan; Dong Hao; Xin-Wen Niu; Mao-Sheng Cheng
Journal:  Molecules       Date:  2007-04-30       Impact factor: 4.411

10.  Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53-HDM2 Protein-Protein Interaction.

Authors:  Peter M Fischer
Journal:  Int J Pept Res Ther       Date:  2006-03-15       Impact factor: 1.931
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