Alice Laudisio1, Silvia Giovannini2, Panaiotis Finamore1, Claudia Loreti3, Federica Vannetti4, Daniele Coraci5, Raffaele Antonelli Incalzi1, Giuseppe Zuccal5, Claudio Macchi4, Luca Padua5. 1. Unit of Geriatrics, Department of Medicine, Campus Bio-Medico di Roma University, Rome, Italy. 2. Department of Aging, Neurological, Orthopaedic and Head-Neck Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. Electronic address: silvia_giovannini@yahoo.it. 3. Department of Aging, Neurological, Orthopaedic and Head-Neck Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. 4. IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy. 5. Department of Aging, Neurological, Orthopaedic and Head-Neck Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore di Roma, Rome, Italy.
Abstract
PURPOSE OF THE STUDY: Quality of life represents the principal outcome of health interventions for the oldest old. However, little is known about the determinants of quality of life in this population stratum. We evaluated the association between health-related quality of life (HRQoL) and handgrip strength in a cohort of 331 participants aged 90+ with a living in the Mugello area (Tuscany, Italy). DESIGN AND METHODS: HRQoL was assessed using the Medical Outcomes Study Short Form 12 (SF12), considering the Physical Composite Score (PCS) and the Mental Composite Score (MCS) of the SF-12. Muscle strength was tested by hand grip dynamometry. RESULTS: The median MCS was 46.9, while the median PCS was 43.0. According to logistic regression, muscle strength was associated with increased probability of better PCS (OR = 1.05; 95 % CI = 1.01-1.10, P = .042), and better MCS (OR = 1.05; 95 % CI = 1.01-1.10, P = .036), after adjusting. IMPLICATION: Muscle strength is associated with both physical and mental HRQoL among nonagenarians. Further studies are needed to explore the subsystems involved in this association, and whether improving muscle performance might improve global mental and physical quality of life in the most advanced age.
PURPOSE OF THE STUDY: Quality of life represents the principal outcome of health interventions for the oldest old. However, little is known about the determinants of quality of life in this population stratum. We evaluated the association between health-related quality of life (HRQoL) and handgrip strength in a cohort of 331 participants aged 90+ with a living in the Mugello area (Tuscany, Italy). DESIGN AND METHODS: HRQoL was assessed using the Medical Outcomes Study Short Form 12 (SF12), considering the Physical Composite Score (PCS) and the Mental Composite Score (MCS) of the SF-12. Muscle strength was tested by hand grip dynamometry. RESULTS: The median MCS was 46.9, while the median PCS was 43.0. According to logistic regression, muscle strength was associated with increased probability of better PCS (OR = 1.05; 95 % CI = 1.01-1.10, P = .042), and better MCS (OR = 1.05; 95 % CI = 1.01-1.10, P = .036), after adjusting. IMPLICATION: Muscle strength is associated with both physical and mental HRQoL among nonagenarians. Further studies are needed to explore the subsystems involved in this association, and whether improving muscle performance might improve global mental and physical quality of life in the most advanced age.
Authors: Sara Salini; Silvia Giovannini; Marcello Covino; Christian Barillaro; Nicola Acampora; Ester Manes Gravina; Claudia Loreti; Francesco Paolo Damiano; Francesco Franceschi; Andrea Russo Journal: Diagnostics (Basel) Date: 2022-05-13