Özlem Bahadır Acikara 1 , Betül Sever Yilmaz 1 , Dilhun Yazgan 1 , Gülçin Saltan Işcan 1 Show Affiliations »
Abstract
OBJECTIVES: This study describes the qualitative and quantitative analysis of galantamine in Sternbergia species growing in Turkey. MATERIALS AND METHODS: Galantamine was isolated from Sternbergia fischeriana bulbs and the structure of the compound elucidated by spectroscopic methods. The qualitative and quantitative analysis of galantamine was investigated in Sternbergia lutea subsp. lutea, S. lutea subsp. sicula, Sternbergia candida, S. fischeriana, and Sternbergia clusiana using a specially developed and validated high performance liquid chromatography (HPLC) method. RESULTS: S. lutea subsp. sicula had the highest content of galantamine, i.e., 0.0165±0.0002 g/100 g. The limits of detection and quantification were 7.5 μg and 25 μg, respectively. CONCLUSION: Isolation of galantamine from S. fischeriana growing in Turkey is reported for the first time. An HPLC method was developed for identification and quantification of galantamine in Sternbergia species. ©Copyright 2019 Turk J Pharm Sci, Published by Galenos Publishing House.
OBJECTIVES: This study describes the qualitative and quantitative analysis of galantamine in Sternbergia species growing in Turkey. MATERIALS AND METHODS: Galantamine was isolated from Sternbergia fischeriana bulbs and the structure of the compound elucidated by spectroscopic methods. The qualitative and quantitative analysis of galantamine was investigated in Sternbergia lutea subsp. lutea, S. lutea subsp. sicula, Sternbergia candida, S. fischeriana, and Sternbergia clusiana using a specially developed and validated high performance liquid chromatography (HPLC) method. RESULTS: S. lutea subsp. sicula had the highest content of galantamine, i.e., 0.0165±0.0002 g/100 g. The limits of detection and quantification were 7.5 μg and 25 μg, respectively. CONCLUSION: Isolation of galantamine from S. fischeriana growing in Turkey is reported for the first time. An HPLC method was developed for identification and quantification of galantamine in Sternbergia species. ©Copyright 2019 Turk J Pharm Sci, Published by Galenos Publishing House.
Entities: Chemical
Keywords:
Galantamine; HPLC; Sternbergia spp
Year: 2018
PMID： 32454692 PMCID： PMC7227991 DOI： 10.4274/tjps.95967
Source DB: PubMed Journal: Turk J Pharm Sci ISSN： 1304-530X