Literature DB >> 3245390

The influence of increasing glucose concentrations on selected functions of polymorphonuclear neutrophils.

B Wierusz-Wysocka1, H Wysocki, A Wykretowicz, R Klimas.   

Abstract

The influence of increasing glucose concentrations on some essential functions in polymorphonuclear neutrophils (PMN) was evaluated in vitro in 20 healthy persons. PMN chemotaxis, adherence, phagocytosis and bactericidal capacity were estimated. Higher than physiologic glucose concentrations were found to diminish chemotaxis, phagocytosis and bactericidal capacity. The results obtained may indicate another possible mechanism that accounts for the increased susceptibility to infection observed in diabetic patients. However, PMN adherence rose parallel with increasing glucose concentrations reaching maximum values at 300 mg/dl (16.6 mmol/l). The changes of PMN adherence may suggest the participation of these cells in the development of microangiopathic injuries.

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Year:  1988        PMID： 3245390     DOI： 10.1007/bf02581126

Source DB:  PubMed          Journal:  Acta Diabetol Lat        ISSN： 0001-5563


  14 in total

1.  Assessment of blood leukocyte microbial killing by using a new fluorochrome microassay.

Authors:  C G Pantazis; W T Kniker
Journal:  J Reticuloendothel Soc       Date:  1979-08

2.  Impaired leukocyte function in patients with poorly controlled diabetes.

Authors:  J D Bagdade; R K Root; R J Bulger
Journal:  Diabetes       Date:  1974-01       Impact factor: 9.461

3.  Glycaemic control and suppressor cell activity in patients with insulin-dependent diabetes mellitus.

Authors:  K Buschard; S Madsbad; T Krarup; J Rygaard
Journal:  Clin Exp Immunol       Date:  1982-04       Impact factor: 4.330

4.  Phagocytic and bactericidal activity of granulocytes in diabetic children.

Authors:  H Dziatkowiak; M Kowalska; A Denys
Journal:  Diabetes       Date:  1982-12       Impact factor: 9.461

5.  Impaired granulocyte adherence. A reversible defect in host defense in patients with poorly controlled diabetes.

Authors:  J D Bagdade; M Stewart; E Walters
Journal:  Diabetes       Date:  1978-06       Impact factor: 9.461

6.  Antiadhesive properties of biological surfaces are protective against stimulated granulocytes.

Authors:  J Fehr; R Moser; D Leppert; P Groscurth
Journal:  J Clin Invest       Date:  1985-08       Impact factor: 14.808

Review 7.  Infection and diabetes: the case for glucose control.

Authors:  E J Rayfield; M J Ault; G T Keusch; M J Brothers; C Nechemias; H Smith
Journal:  Am J Med       Date:  1982-03       Impact factor: 4.965

8.  Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes.

Authors:  P R Craddock; J Fehr; A P Dalmasso; K L Brighan; H S Jacob
Journal:  J Clin Invest       Date:  1977-05       Impact factor: 14.808

9.  Diabetes and neutrophil chemotaxis.

Authors:  S M Fikrig; C M Reddy; E Orti; L Herod; K Suntharalingam
Journal:  Diabetes       Date:  1977-05       Impact factor: 9.461

10.  In vitro granulocyte adherence and in vivo margination: two associated complement-dependent functions. Studies based on the acute neutropenia of filtration leukophoresis.

Authors:  J Fehr; H S Jacob
Journal:  J Exp Med       Date:  1977-09-01       Impact factor: 14.307
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  6 in total

1.  Low prevalence of rheumatoid arthritis among patients with pre-existing type 2 diabetes mellitus.

Authors:  Anastasios Tentolouris; Anastasia Thanopoulou; Nikolaos Tentolouris; Ioanna Eleftheriadou; Christina Voulgari; Alexandros Andrianakos; Petros P Sfikakis
Journal:  Ann Transl Med       Date:  2018-10

2.  Rejuvenation of Neutrophil Functions in Association With Reduced Diabetes Risk Following Ten Weeks of Low-Volume High Intensity Interval Walking in Older Adults With Prediabetes - A Pilot Study.

Authors:  David B Bartlett; Cris A Slentz; Leslie H Willis; Andrew Hoselton; Janet L Huebner; Virginia B Kraus; Jennifer Moss; Michael J Muehlbauer; Guillaume Spielmann; Deborah M Muoio; Timothy R Koves; Helena Wu; Kim M Huffman; Janet M Lord; William E Kraus
Journal:  Front Immunol       Date:  2020-05-05       Impact factor: 7.561

Review 3.  Studying Neutrophil Function in vitro: Cell Models and Environmental Factors.

Authors:  Marfa Blanter; Mieke Gouwy; Sofie Struyf
Journal:  J Inflamm Res       Date:  2021-01-20

4.  Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans.

Authors:  M E Stegenga; S N van der Crabben; M C Dessing; J M Pater; P S van den Pangaart; A F de Vos; M W Tanck; D Roos; H P Sauerwein; T van der Poll
Journal:  Diabet Med       Date:  2008-02       Impact factor: 4.359

5.  The impact of hyperglycemia on risk of severe infections during early period of induction therapy in patients with newly diagnosed multiple myeloma.

Authors:  Sung-Hoon Jung; Hee-Chang Jang; Seung-Shin Lee; Jae-Sook Ahn; Deok-Hwan Yang; Yeo-Kyeoung Kim; Hyeoung-Joon Kim; Je-Jung Lee
Journal:  Biomed Res Int       Date:  2014-04-16       Impact factor: 3.411

6.  Considerations for people with diabetes during the Coronavirus Disease (COVID-19) pandemic.

Authors:  Lori J Sacks; Cecilia T Pham; Nicola Fleming; Sandra L Neoh; Elif I Ekinci
Journal:  Diabetes Res Clin Pract       Date:  2020-07-03       Impact factor: 5.602
  6 in total

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