Min Young Lee1, Young Cheol Kim2, Jongmoon Jang3, Jae Yun Jung1, Hongsoo Choi3, Jeong Hun Jang2, Yun-Hoon Choung2. 1. Department of Otolaryngology, Dankook University School of Medicine, Cheonan, South Korea. 2. Department of Otorhinolaryngology, Ajou University School of Medicine, Suwon, South Korea. 3. Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea.
Abstract
Background: Clinically, steroids have been used for hearing preservation both topically and systemically during cochlear implantation.Objective: This study compared steroid efficacy for hearing preservation among different types of delivery modes using an animal experiment.Materials and methods: For 76 guinea pigs, topical and systemic delivery methods, four pump types with different infusion rates, delivery durations, and total steroid amounts were used. Threshold changes of 8, 16, and 32 kHz after dummy electrode insertion were evaluated at 1 and 4 weeks and compared among delivery method and pump types. Inflammatory response in the cochlea was histologically compared. Results: For topical delivery groups, long-term release showed advantages in preserving hearing. Systemic delivery groups showed smaller threshold shifts than control group in all frequencies (p > .05). In short-term low dose application, compared to topical delivery, systemic delivery showed advantage in hearing preservation at both time point. However, others fail to show significant difference between two methods. Histologically, inflammatory response in the scala tympani at the basal turn was less in systemic delivery, especially in high dose and long-term.Conclusion and significance: The difference of hearing preservation was not obvious between two delivery methods. Higher dose and longer duration might have advantages in hearing preservation.
Background: Clinically, steroids have been used for hearing preservation both topically and systemically during cochlear implantation.Objective: This study compared steroid efficacy for hearing preservation among different types of delivery modes using an animal experiment.Materials and methods: For 76 guinea pigs, topical and systemic delivery methods, four pump types with different infusion rates, delivery durations, and total steroid amounts were used. Threshold changes of 8, 16, and 32 kHz after dummy electrode insertion were evaluated at 1 and 4 weeks and compared among delivery method and pump types. Inflammatory response in the cochlea was histologically compared. Results: For topical delivery groups, long-term release showed advantages in preserving hearing. Systemic delivery groups showed smaller threshold shifts than control group in all frequencies (p > .05). In short-term low dose application, compared to topical delivery, systemic delivery showed advantage in hearing preservation at both time point. However, others fail to show significant difference between two methods. Histologically, inflammatory response in the scala tympani at the basal turn was less in systemic delivery, especially in high dose and long-term.Conclusion and significance: The difference of hearing preservation was not obvious between two delivery methods. Higher dose and longer duration might have advantages in hearing preservation.
Entities:
Keywords:
Dexamethasone; cochlear implantation; drug delivery; hearing preservation; mechanical trauma
Authors: Cristina Maria Blebea; Violeta Necula; Monica Potara; Maximilian George Dindelegan; Laszlo Peter Ujvary; Emil Claudiu Botan; Alma Aurelia Maniu; Marcel Cosgarea Journal: Audiol Res Date: 2022-08-28