Literature DB >> 324481

Immunohistochemical localization of prostaglandin E in rheumatoid synovial tissues.

G Husby, A D Bankhurst, R C Williams.   

Abstract

Synovial tissues removed at synovectomy from patients with active rheumatoid arthritis (RA) or osteoarthritis (OA) were examined for prostaglandin E (PGE) by immunohistochemical techniques using rabbit antisera specific for PGE. Marked increments of PGE were noted in RA synovia in comparison to OA, with staining concentrated in synovial lining cells, interstitial inflammatory cells, and endothelial cells of blood vessels. A correlation was noted between the degree of synovial lymphocytic infiltrate and the intensity of PGE staining. These studies provide initial cellular localization of PGE in such tissues.

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Year:  1977        PMID： 324481     DOI： 10.1002/art.1780200304

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  9 in total

Review 1.  The contribution made by cytochemistry to the study of the metabolism of the normal and rheumatoid synovial lining cell (synoviocyte).

Authors:  B Henderson
Journal:  Histochem J       Date:  1982-07

2.  Production of prostanoids by rheumatic synovial cells in vitro: effects of anti-inflammatory drugs on arachidonic acid metabolism.

Authors:  E Seppälä
Journal:  Clin Rheumatol       Date:  1987-06       Impact factor: 2.980

3.  Differences in prostanoid production between healthy and rheumatic synovia in vitro.

Authors:  E Moilanen; E Seppälä; M Nissilä; H Vapaatalo
Journal:  Agents Actions       Date:  1987-02

4.  Bradykinin-stimulated prostaglandin E2 production by endothelial cells and its modulation by antiinflammatory compounds.

Authors:  P J Jose; D A Page; B E Wolstenholme; T J Williams; D C Dumonde
Journal:  Inflammation       Date:  1981-12       Impact factor: 4.092

5.  Influence of interleukin-1 beta, tumour necrosis factor alpha and prostaglandin E2 on chondrogenesis and cartilage matrix breakdown in vitro.

Authors:  H Mohamed-Ali
Journal:  Rheumatol Int       Date:  1995       Impact factor: 2.631

6.  Change of prostaglandin E level in joint fluids after treatment with flurbiprofen in patients with rheumatoid arthritis and osteoarthritis.

Authors:  M Tokunaga; K Ohuchi; S Yoshizawa; S Tsurufuji; A Rikimaru; E Wakamatsu
Journal:  Ann Rheum Dis       Date:  1981-10       Impact factor: 19.103

7.  Cytosolic phospholipase A2 modulates TLR2 signaling in synoviocytes.

Authors:  Randi M Sommerfelt; Astrid J Feuerherm; Trine Skuland; Berit Johansen
Journal:  PLoS One       Date:  2015-04-20       Impact factor: 3.240

8.  Robust COX-2-mediated prostaglandin response may drive arthralgia and bone destruction in patients with chronic inflammation post-chikungunya.

Authors:  Yosra Bedoui; Axelle Septembre-Malaterre; Claude Giry; Marie-Christine Jaffar-Bandjee; Jimmy Selambarom; Pascale Guiraud; Philippe Gasque
Journal:  PLoS Negl Trop Dis       Date:  2021-02-17

Review 9.  Endothelial cell phenotypes in the rheumatoid synovium: activated, angiogenic, apoptotic and leaky.

Authors:  Jim Middleton; Laure Americh; Regis Gayon; Denis Julien; Luc Aguilar; Francois Amalric; Jean-Philippe Girard
Journal:  Arthritis Res Ther       Date:  2004-03-08       Impact factor: 5.156
  9 in total

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