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Literature DB >> 6799400

Bradykinin-stimulated prostaglandin E2 production by endothelial cells and its modulation by antiinflammatory compounds.

P J Jose, D A Page, B E Wolstenholme, T J Williams, D C Dumonde.

Abstract

Prostaglandin production was studied in cultures of pig aorta endothelial cells using radioimmunoassay, radiochromatography, and smooth muscle bioassay. PGE2 was produced in higher concentrations than other prostaglandins. Bradykinin produced a rapid dose-related stimulation of PGE2 production. These results provided the basis for establishment of a simplified test system for investigating new compounds which alter prostaglandin synthesis and might therefore affect inflammatory response. It was also observed that these endothelial cells do not metabolize prostaglandins via 15-hydroxyprostaglandin dehydrogenase.

Entities: Chemical Gene Species

Mesh：

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Year: 1981 PMID： 6799400 DOI： 10.1007/BF00911100

Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092

25 in total

1. Localisation and stimulation of prostacyclin production in vascular cells.

Authors: D E MacIntyre; J D Pearson; J L Gordon
Journal: Nature Date: 1978-02-09 Impact factor: 49.962

2. Effects of cytotoxic sera on endothelium in vitro.

Authors: D De Bono
Journal: Nature Date: 1974-11-01 Impact factor: 49.962

3. Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs.

Authors: P J Piper; J R Vane
Journal: Nature Date: 1969-07-05 Impact factor: 49.962

4. Drugs which inhibit prostaglandin biosynthesis.

Authors: R J Flower
Journal: Pharmacol Rev Date: 1974-03 Impact factor: 25.468

5. Degradation of porstaglandin F2alpha in the human pulmonary circulation.

Authors: P Jose; U Niederhauser; P J Piper; C Robinson; A P Smith
Journal: Thorax Date: 1976-12 Impact factor: 9.139

6. Stimulation of prostaglandin synthesis by bradykinin and thrombin and their mechanisms of action on MC5-5 fibroblasts.

Authors: S L Hong; L Levine
Journal: J Biol Chem Date: 1976-09-25 Impact factor: 5.157

7. Bradykinin-stimulated release of [3H]arachidonic acid from phospholipids of HSDM1C1 cells: comparison of diacyl phospholipids and plasmalogens as sources of prostaglandin precursors.

Authors: J M Schremmer; M L Blank; R L Wykle
Journal: Prostaglandins Date: 1979-10

2. Immunosuppressive actions of prostaglandins and the possible increase in chronic inflammation after cyclo-oxygenase inhibitors.

Authors: G P Lewis; M L Barrett
Journal: Agents Actions Date: 1986-10

6. The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat.

Authors: H Emms; G P Lewis
Journal: Br J Pharmacol Date: 1986-01 Impact factor: 8.739

6 in total

Bradykinin-stimulated prostaglandin E2 production by endothelial cells and its modulation by antiinflammatory compounds.

1. Localisation and stimulation of prostacyclin production in vascular cells.

2. Effects of cytotoxic sera on endothelium in vitro.

3. Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs.

4. Drugs which inhibit prostaglandin biosynthesis.

5. Degradation of porstaglandin F2alpha in the human pulmonary circulation.

6. Stimulation of prostaglandin synthesis by bradykinin and thrombin and their mechanisms of action on MC5-5 fibroblasts.

7. Bradykinin-stimulated release of [3H]arachidonic acid from phospholipids of HSDM1C1 cells: comparison of diacyl phospholipids and plasmalogens as sources of prostaglandin precursors.

8. Hydrocortisone inhibition of the bradykinin activation of human synovial fibroblasts.

9. PGA1 and PGF2 alpha metabolism by pig pulmonary endothelium, smooth muscle, and fibroblasts.

10. Prostaglandins, oxygen tension and smooth muscle tone.

1. Bradykinin-induced plasma exudation in guinea-pig airways: involvement of platelet activating factor.

2. Immunosuppressive actions of prostaglandins and the possible increase in chronic inflammation after cyclo-oxygenase inhibitors.

3. Prostaglandins in pathological bone resorption.

4. Structural correlations of phorbol-ester-induced stimulation of PGE2 production by human rheumatoid synovial cells.

5. Effects of piroxicam on mononuclear cells. Comparison with other antiarthritic drugs.

6. The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat.