| Literature DB >> 32447845 |
Felix Lauffer1, Kilian Eyerich1, Wolf-Henning Boehncke2, Khusru Asadullah3, Stefan Beissert4, Kamran Ghoreschi5, Michael P Schön6,7.
Abstract
Various immune cells and their messenger substances influence the development of psoriasis. Cytokines of the IL-17 family are of particular importance. In addition to IL-17A, which plays a central role in the pathogenesis of psoriasis, other subtypes of the IL-17 family also have a proinflammatory effect. This review provides an up-to-date overview of the immunopathogenesis of psoriasis with regard to the six IL-17 subtypes, in particular their physiological and pathogenic properties, as well as their significance for psoriasis therapy.Entities:
Year: 2020 PMID: 32447845 DOI: 10.1111/ddg.14124
Source DB: PubMed Journal: J Dtsch Dermatol Ges ISSN: 1610-0379 Impact factor: 5.584