PURPOSE: Obstructive sleep apnea syndrome is a clinical sleep disorder defined by total or partial airflow restraint during sleep that results in fragmented sleep and hypoxemia, impacting negatively with cognitive functioning. This review was conducted on studies investigating structural brain alteration and cognitive impairment in obstructive sleep apnea syndrome. METHOD: We searched on PubMed databases and screening references of included studies and review articles for additional citations. From initial 190 publications, only 17 met search criteria and described the cognitive impairment in obstructive sleep apnea syndrome. RESULTS: Findings showed that patients with this syndrome had worse performance than healthy controls in attention, memory, and executive functions, showing specific neuroanathomical features. Cognitive impairment is also related to the severity of pathology. Treatment could improve certain cognitive aspects. CONCLUSIONS: Cognitive deficits seem to be mainly attributable to decreased daytime vigilance and nocturnal hypoxemia.
PURPOSE:Obstructive sleep apnea syndrome is a clinical sleep disorder defined by total or partial airflow restraint during sleep that results in fragmented sleep and hypoxemia, impacting negatively with cognitive functioning. This review was conducted on studies investigating structural brain alteration and cognitive impairment in obstructive sleep apnea syndrome. METHOD: We searched on PubMed databases and screening references of included studies and review articles for additional citations. From initial 190 publications, only 17 met search criteria and described the cognitive impairment in obstructive sleep apnea syndrome. RESULTS: Findings showed that patients with this syndrome had worse performance than healthy controls in attention, memory, and executive functions, showing specific neuroanathomical features. Cognitive impairment is also related to the severity of pathology. Treatment could improve certain cognitive aspects. CONCLUSIONS:Cognitive deficits seem to be mainly attributable to decreased daytime vigilance and nocturnal hypoxemia.
Authors: Raffaele Nardone; Jürgen Bergmann; Francesco Brigo; Yvonne Höller; Kerstin Schwenker; Cristina Florea; Alexander B Kunz; Stefan Golaszewski; Eugen Trinka Journal: Sleep Med Date: 2016-08-26 Impact factor: 3.492
Authors: Isaac Shpirer; Arnon Elizur; Ran Shorer; Ruth Bernstein Peretz; Jose M Rabey; Michael Khaigrekht Journal: Sleep Breath Date: 2011-09-04 Impact factor: 2.816
Authors: Kingman P Strohl; Daniel B Brown; Nancy Collop; Charles George; Ronald Grunstein; Fang Han; Lawrence Kline; Atul Malhotra; Alan Pack; Barbara Phillips; Daniel Rodenstein; Richard Schwab; Terri Weaver; Kevin Wilson Journal: Am J Respir Crit Care Med Date: 2013-06-01 Impact factor: 21.405