Emilie Crawford-Achour1,2, Virginie Dauphinot3, Magali Saint Martin4, Magali Tardy5, Régis Gonthier2, Jean Claude Barthelemy1, Frédéric Roche1,4. 1. Laboratoire de Physiologie de l'exercice, Equipe SNA Epis EA 4607, Université Jean Monnet, Faculté de médecine J. Lisfranc, Hôpital universitaire, Saint-Etienne, France. 2. Département de Gérontologie clinique, Université Jean Monnet, Faculté de médecine J. Lisfranc, Hôpital universitaire, Saint-Etienne, France. 3. Centre Mémoire de Ressources et de Recherche de Lyon, Hôpital des Charpennes, Hospices Civils de Lyon, Villeurbanne, France. 4. Centre VISA, Université Jean Monnet, Faculté de médecine J. Lisfranc, Hôpital général, Saint-Chamond, France. 5. Département de Gérontologie clinique, Université Jean Monnet, Faculté de médecine J. Lisfranc, Hôpital général, Saint-Chamond, France.
Abstract
OBJECTIVE: Obstructive sleep apnea syndrome (OSA) leads to a deterioration in cognitive functions, with regard to memory and executive functions. However, few studies have investigated the impact of treatment on these cognitive functions in elderly subjects. METHODS: The study was conducted in a large cohort of subjects aged 65 years or older (the PROOF cohort). Subjects were not diagnosed or treated for OSA. Subjects underwent a polygraphic recording. Cognitive performance was assessed in all OSA subjects at baseline and 10 years later, whether or not they were receiving continuous positive airway pressure (CPAP) therapy. RESULTS: A group of 126 patients were analyzed. Only 26% of them were treated, with therapy initiated at the discretion of the primary care physician. Among treated subjects, self-reported compliance with therapy was good (> 6 h/night on average), and 66% of them reported an improvement in their quality of life. Patients receiving CPAP treatment had a higher apneahypopnea index (p = 0.006), a higher oxygen desaturation index (p < 0.001), and experienced more pronounced daytime repercussions (p = 0.004). These patients showed a statistically significant improvement in mental agility (similarities test; p < 0.0001) and memory performance (Grober and Buschke delayed free recall; p = 0.02). CONCLUSION: CPAP treatment is associated with the maintenance of memory performance over time.
OBJECTIVE: Obstructive sleep apnea syndrome (OSA) leads to a deterioration in cognitive functions, with regard to memory and executive functions. However, few studies have investigated the impact of treatment on these cognitive functions in elderly subjects. METHODS: The study was conducted in a large cohort of subjects aged 65 years or older (the PROOF cohort). Subjects were not diagnosed or treated for OSA. Subjects underwent a polygraphic recording. Cognitive performance was assessed in all OSA subjects at baseline and 10 years later, whether or not they were receiving continuous positive airway pressure (CPAP) therapy. RESULTS: A group of 126 patients were analyzed. Only 26% of them were treated, with therapy initiated at the discretion of the primary care physician. Among treated subjects, self-reported compliance with therapy was good (> 6 h/night on average), and 66% of them reported an improvement in their quality of life. Patients receiving CPAP treatment had a higher apneahypopnea index (p = 0.006), a higher oxygen desaturation index (p < 0.001), and experienced more pronounced daytime repercussions (p = 0.004). These patients showed a statistically significant improvement in mental agility (similarities test; p < 0.0001) and memory performance (Grober and Buschke delayed free recall; p = 0.02). CONCLUSION: CPAP treatment is associated with the maintenance of memory performance over time.
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