Sheila Keogan1, Tamara Alonso2,3, Salome Sunday1, Olena Tigova3,4,5,6, Esteve Fernández3,4,5,6, María José López7,8,9, Silvano Gallus10, Sean Semple11, Ana Tzortzi12, Roberto Boffi13, Giuseppe Gorini14, Ángel López-Nicolás15, Cornel Radu-Loghin16, Joan B Soriano2,3, Luke Clancy1. 1. TobaccoFree Research Institute Ireland, Focas Research Institute, DIT, Dublin, Ireland. 2. Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain. 3. Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. 4. Tobacco Control Unit, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain. 5. Tobacco Control Research Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain. 6. School of Medicine and Health Sciences, Bellvitge Campus, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain. 7. Agència de Salut Pública de Barcelona, Barcelona, Spain. 8. CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. 9. Institut d'Investigació Biomèdica Sant Pau (IIB St. Pau), Barcelona, Spain. 10. Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy. 11. Institute for Social Marketing, University of Stirling, Stirling, Scotland, UK. 12. Institute of Public Health of the American College of Greece, Athens, Greece. 13. Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. 14. Istituto per lo Studio, la Prevenzione e la Rete Oncologica, Florence, Italy. 15. Universidad Politécnica de Cartagena, Cartagena, Spain. 16. European Network for Smoking and Tobacco Prevention, Brussels, Belgium.
Abstract
BACKGROUND: Further evidence is needed on the effects that short- and long-term exposure to secondhand smoke (SHS) have on the respiratory health of patients with lung disease. Within the TackSHS project we aimed to assess the acute respiratory effects in lung function that result from short-term SHS exposure among patients with asthma and chronic obstructive pulmonary disease (COPD). METHODS: The study design was an intervention trial with measurements before/after exposure to SHS in legal outdoor smoking areas. We studied patients with asthma or COPD from Czechia, Ireland, and Spain. Forced spirometry, peak flow and carbon monoxide (CO) measurements were performed pre- and 24 h post- exposure. RESULTS: Overall, 60 patients were studied, 30 with asthma, and 30 with COPD; 35 (58.3%) were female. There were no significant differences observed in exhaled CO between pre- and 24 h post-exposure neither in women (p = 0.210), nor in men (p = 0.169).A statistically significant decrease in forced vital capacity (FVC) was seen, overall, in asthma participants (p = 0.02) and in forced expiratory volume in the first second (FEV1), (p = 0.02), FVC (p = 0.04) and peak expiratory flow rate (PEFR) (p = 0.04) in female asthmatic participants. The observed decreases in respiratory measurements in COPD were not significant. There were no reported increases in symptoms, respiratory medication, or use of health services 24 h after the exposure. CONCLUSION: We conclude that acute, short-term SHS exposure had a statistically significant effect on spirometry in female asthma patients but did not significantly modify spirometric indices 24 h later in COPD patients.
RCT Entities:
BACKGROUND: Further evidence is needed on the effects that short- and long-term exposure to secondhand smoke (SHS) have on the respiratory health of patients with lung disease. Within the TackSHS project we aimed to assess the acute respiratory effects in lung function that result from short-term SHS exposure among patients with asthma and chronic obstructive pulmonary disease (COPD). METHODS: The study design was an intervention trial with measurements before/after exposure to SHS in legal outdoor smoking areas. We studied patients with asthma or COPD from Czechia, Ireland, and Spain. Forced spirometry, peak flow and carbon monoxide (CO) measurements were performed pre- and 24 h post- exposure. RESULTS: Overall, 60 patients were studied, 30 with asthma, and 30 with COPD; 35 (58.3%) were female. There were no significant differences observed in exhaled CO between pre- and 24 h post-exposure neither in women (p = 0.210), nor in men (p = 0.169).A statistically significant decrease in forced vital capacity (FVC) was seen, overall, in asthmaparticipants (p = 0.02) and in forced expiratory volume in the first second (FEV1), (p = 0.02), FVC (p = 0.04) and peak expiratory flow rate (PEFR) (p = 0.04) in female asthmatic participants. The observed decreases in respiratory measurements in COPD were not significant. There were no reported increases in symptoms, respiratory medication, or use of health services 24 h after the exposure. CONCLUSION: We conclude that acute, short-term SHS exposure had a statistically significant effect on spirometry in female asthmapatients but did not significantly modify spirometric indices 24 h later in COPDpatients.