Nivaas Thanoo1, Abigail L Gilbert2, Sean Trainor3,4, Pamela A Semanik5,6, Jing Song4, Jungwha Lee3,4, Dorothy D Dunlop3,4,7, Rowland W Chang3,4,5,7. 1. Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. 2. Department of Medicine, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina, USA. 3. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. 4. Institute of Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. 5. Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. 6. Department of Adult Health and Gerontological Nursing, Rush University College of Nursing, Chicago, Illinois, USA. 7. Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Abstract
OBJECTIVES: Physical activity is associated with improved pain, functional status, and less disability in persons with knee osteoarthritis (KOA). Because polypharmacy is related to several adverse health outcomes in older persons, we hypothesized that it might also be associated with decreased physical activity in those with KOA. This study evaluates the relationship between the number of prescription medications and weekly moderate to vigorous physical activity (MVPA). DESIGN: We used hierarchical median quantile regression analysis to examine the cross-sectional association between the number of prescription medications taken in the past 30 days and the median objectively measured MVPA minutes controlling for demographic and clinical variables. SETTING: Four Osteoarthritis Initiative (OAI) recruitment centers in Providence, Rhode Island; Columbus, Ohio; Baltimore, Maryland; and Pittsburgh, Pennsylvania. PARTICIPANTS: Accelerometer monitoring occurred in 2,127 OAI participants. Of these, 1,889 participants had 4 or more days of valid physical activity monitoring data and complete medication/covariate data. Data were collected at the 48-month OAI follow-up visit (2008-2010). MEASUREMENTS: The outcome was weekly minutes of MVPA measured with an accelerometer. Number/type of prescribed medications and covariate data (age, sex, race/ethnicity, body mass index, presence of comorbidities, pain, depressive symptoms, and radiographic KOA severity) were taken from the public OAI database. Polypharmacy was defined as taking five or more prescribed medications. RESULTS: The prevalence of polypharmacy in the study population was 28.2%. Each additional prescription medication was related to a decrease of 3.6 minutes (95% confidence interval [CI] = -4.8 to -2.1) in median weekly MVPA minutes. Participants meeting the polypharmacy criterion exhibited a decrease of 12.6 minutes (95% CI = -21.2 to -4.7) in median weekly MVPA minutes compared with those not meeting the criterion. CONCLUSION: An increased number of prescription medications and polypharmacy are associated cross-sectionally with decreased MVPA in adults with KOA. Further study is necessary to establish the causal nature of this association.
OBJECTIVES: Physical activity is associated with improved pain, functional status, and less disability in persons with knee osteoarthritis (KOA). Because polypharmacy is related to several adverse health outcomes in older persons, we hypothesized that it might also be associated with decreased physical activity in those with KOA. This study evaluates the relationship between the number of prescription medications and weekly moderate to vigorous physical activity (MVPA). DESIGN: We used hierarchical median quantile regression analysis to examine the cross-sectional association between the number of prescription medications taken in the past 30 days and the median objectively measured MVPA minutes controlling for demographic and clinical variables. SETTING: Four Osteoarthritis Initiative (OAI) recruitment centers in Providence, Rhode Island; Columbus, Ohio; Baltimore, Maryland; and Pittsburgh, Pennsylvania. PARTICIPANTS: Accelerometer monitoring occurred in 2,127 OAI participants. Of these, 1,889 participants had 4 or more days of valid physical activity monitoring data and complete medication/covariate data. Data were collected at the 48-month OAI follow-up visit (2008-2010). MEASUREMENTS: The outcome was weekly minutes of MVPA measured with an accelerometer. Number/type of prescribed medications and covariate data (age, sex, race/ethnicity, body mass index, presence of comorbidities, pain, depressive symptoms, and radiographic KOA severity) were taken from the public OAI database. Polypharmacy was defined as taking five or more prescribed medications. RESULTS: The prevalence of polypharmacy in the study population was 28.2%. Each additional prescription medication was related to a decrease of 3.6 minutes (95% confidence interval [CI] = -4.8 to -2.1) in median weekly MVPA minutes. Participants meeting the polypharmacy criterion exhibited a decrease of 12.6 minutes (95% CI = -21.2 to -4.7) in median weekly MVPA minutes compared with those not meeting the criterion. CONCLUSION: An increased number of prescription medications and polypharmacy are associated cross-sectionally with decreased MVPA in adults with KOA. Further study is necessary to establish the causal nature of this association.
Authors: Jungwha Lee; Rowland W Chang; Linda Ehrlich-Jones; C Kent Kwoh; Michael Nevitt; Pamela A Semanik; Leena Sharma; Min-Woong Sohn; Jing Song; Dorothy D Dunlop Journal: Arthritis Care Res (Hoboken) Date: 2015-03 Impact factor: 4.794
Authors: Ian J Wallace; Steven Worthington; David T Felson; Robert D Jurmain; Kimberly T Wren; Heli Maijanen; Robert J Woods; Daniel E Lieberman Journal: Proc Natl Acad Sci U S A Date: 2017-08-14 Impact factor: 11.205
Authors: Jing Song; Abigail L Gilbert; Rowland W Chang; Christine A Pellegrini; Linda S Ehrlich-Jones; Jungwha Lee; Daniel Pinto; Pamela A Semanik; Leena Sharma; C Kent Kwoh; Rebecca D Jackson; Dorothy D Dunlop Journal: J Clin Rheumatol Date: 2017-01 Impact factor: 3.517
Authors: Louise M Thoma; Dorothy Dunlop; Jing Song; Jungwha Lee; Catrine Tudor-Locke; Elroy J Aguiar; Hiral Master; Meredith B Christiansen; Daniel K White Journal: Arthritis Care Res (Hoboken) Date: 2018-10 Impact factor: 4.794
Authors: Dorothy D Dunlop; Jing Song; Pamela A Semanik; Rowland W Chang; Leena Sharma; Joan M Bathon; Charles B Eaton; Marc C Hochberg; Rebecca D Jackson; C Kent Kwoh; W Jerry Mysiw; Michael C Nevitt; Jennifer M Hootman Journal: Arthritis Rheum Date: 2011-11