A Merkler1, J Sertić2, A Bazina Martinović3, T Križ4, I Miličić5, M Šimić6, D Caban1, H Ljubić1, J Markeljević7, L Šimičević1, S Kaštelan8, I Pećin9, Ž Reiner9. 1. Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia. 2. Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia; University of Zagreb, School of Medicine, Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Zagreb, Croatia. Electronic address: jadranka.sertic@kbc-zagreb.hr. 3. Department of Neurology, University Hospital Centre Zagreb, Zagreb, Croatia. 4. Department of Ophthalmology, University Hospital Centre 'Sestre milosrdnice', Zagreb, Croatia. 5. University of Zagreb, School of Medicine, Zagreb, Croatia. 6. Department of Clinical Microbiology, Andrija Štampar Teaching Institute of Public Health, Zagreb, Croatia. 7. Department of Immunology, Pulmology and Rheumatology, University Hospital Centre 'Sestre milosrdnice', Zagreb, Croatia. 8. Department of Ophthalmology, Clinical Hospital Dubrava, Zagreb, Croatia. 9. University of Zagreb, School of Medicine, Zagreb, Croatia; Department of Internal Medicine, University Hospital Centre Zagreb, Zagreb, Croatia.
Abstract
AIM: Ischemic stroke (IS) is multifactorial disease and therefore different genes and proteins play a role in its development. Haptoglobin (Hp) removes free hemoglobin and protects from iron-induced oxidative damage, inflammatory response, atherosclerosis and cerebrovascular diseases. The aim of this study was to investigate Hp genetic variants in patients with carotid atherosclerotic lesions and IS. MATERIAL AND METHODS: A total of 121 subjects with IS participated in the study, 81 male and 40 female. RESULTS: Among 121 patients with IS, 79 had diffuse atherosclerotic plaques and stenosis. Hp genotype was statistically significantly associated with CDFI neck carotid artery stenosis findings (p = 0.006). Patients with Hp1-2 genotype had statistically significantly larger odds for atherosclerotic changes compared to those with Hp1-1 genotype, as well as those with Hp2-2 genotype. CONCLUSION: This study has shown an association of the Hp2-2 genotype and atherosclerosis in patients with IS, indicating Hp2-2 genotype as a genetic biomarker for precision medicine and personalized healthcare.
AIM: Ischemic stroke (IS) is multifactorial disease and therefore different genes and proteins play a role in its development. Haptoglobin (Hp) removes free hemoglobin and protects from iron-induced oxidative damage, inflammatory response, atherosclerosis and cerebrovascular diseases. The aim of this study was to investigate Hp genetic variants in patients with carotid atherosclerotic lesions and IS. MATERIAL AND METHODS: A total of 121 subjects with IS participated in the study, 81 male and 40 female. RESULTS: Among 121 patients with IS, 79 had diffuse atherosclerotic plaques and stenosis. Hp genotype was statistically significantly associated with CDFI neck carotid artery stenosis findings (p = 0.006). Patients with Hp1-2 genotype had statistically significantly larger odds for atherosclerotic changes compared to those with Hp1-1 genotype, as well as those with Hp2-2 genotype. CONCLUSION: This study has shown an association of the Hp2-2 genotype and atherosclerosis in patients with IS, indicating Hp2-2 genotype as a genetic biomarker for precision medicine and personalized healthcare.
Authors: Christian Bernard Kengne Fotsing; Constant Anatole Pieme; Prosper Cabral Biapa Nya; Jean Paul Chedjou; Solange Dabou; Carine Nguemeni; Georges Teto; Wilfred Fon Mbacham; Donatien Gatsing Journal: Health Sci Rep Date: 2022-01-21