Literature DB >> 3243548

A mapped set of DNA markers for human chromosome 15.

Y Nakamura1, M Lathrop, P O'Connell, M Leppert, J M Lalouel, R White.   

Abstract

A primary genetic linkage map for human chromosome 15 has been constructed from 16 arbitrary DNA markers genotyped in 59 large reference families. The map spans a genetic distance of 146 cM in males and 187 cM in females. The ratio of female/male genetic distance was approximately 2.1 overall within the region of the chromosome covered by our map, but three segments showed a significant male excess in recombination frequency. A subset of seven of the linked markers would be enough to detect linkage of a genetic defect within the mapped region of chromosome 15, if at least 48 phase-known meioses in affected families were available for analysis.

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Year:  1988        PMID： 3243548     DOI： 10.1016/0888-7543(88)90125-5

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  10 in total

1.  Marfan syndrome is closely linked to a marker on chromosome 15q1.5----q2.1.

Authors:  P Tsipouras; M Sarfarazi; A Devi; B Weiffenbach; M Boxer
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

2.  A linkage map of 10 loci flanking the Marfan syndrome locus on 15q: results of an International Consortium study.

Authors:  M Sarfarazi; P Tsipouras; R Del Mastro; M Kilpatrick; P Farndon; M Boxer; A Bridges; C Boileau; C Junien; C Hayward
Journal:  J Med Genet       Date:  1992-02       Impact factor: 6.318

3.  Marfan syndrome: no evidence for heterogeneity in different populations, and more precise mapping of the gene.

Authors:  K Kainulainen; B Steinmann; F Collins; H C Dietz; C A Francomano; A Child; M W Kilpatrick; D J Brock; M Keston; R E Pyeritz
Journal:  Am J Hum Genet       Date:  1991-09       Impact factor: 11.025

4.  Genetic linkage map of 46 DNA markers on human chromosome 16.

Authors:  T P Keith; P Green; S T Reeders; V A Brown; P Phipps; A Bricker; K Falls; K S Rediker; J A Powers; C Hogan
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

5.  Hypervariable regions of DNA for parentage testing and individual identification.

Authors:  T Yokoi; M Nata; T Odaira; K Sagisaka
Journal:  Z Rechtsmed       Date:  1990

6.  Application of single-locus hypervariable region DNA probes to deficiency cases in paternity testing.

Authors:  T Yokoi; T Odaira; M Nata; Y Aoki; K Sagisaka
Journal:  Int J Legal Med       Date:  1991-03       Impact factor: 2.686

7.  Molecular, cytogenetic, and clinical investigations of Prader-Willi syndrome patients.

Authors:  W P Robinson; A Bottani; Y G Xie; J Balakrishman; F Binkert; M Mächler; A Prader; A Schinzel
Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

8.  Detecting high-resolution polymorphisms in human coding loci by combining PCR and single-strand conformation polymorphism (SSCP) analysis.

Authors:  S E Poduslo; M Dean; U Kolch; S J O'Brien
Journal:  Am J Hum Genet       Date:  1991-07       Impact factor: 11.025

9.  A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.

Authors:  H Coon; S Jensen; M Hoff; J Holik; R Plaetke; F Reimherr; P Wender; M Leppert; W Byerley
Journal:  Am J Hum Genet       Date:  1993-06       Impact factor: 11.025

10.  Progress in the search for genetic linkage with Tourette syndrome: an exclusion map covering more than 50% of the autosomal genome.

Authors:  A J Pakstis; P Heutink; D L Pauls; R Kurlan; B J van de Wetering; J F Leckman; L A Sandkuyl; J R Kidd; G J Breedveld; C M Castiglione
Journal:  Am J Hum Genet       Date:  1991-02       Impact factor: 11.025
  10 in total

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