| Literature DB >> 32425159 |
William Hedley Thompson1,2, Jessey Wright1,3, Patrick G Bissett1, Russell A Poldrack1.
Abstract
Open data allows researchers to explore pre-existing datasets in new ways. However, if many researchers reuse the same dataset, multiple statistical testing may increase false positives. Here we demonstrate that sequential hypothesis testing on the same dataset by multiple researchers can inflate error rates. We go on to discuss a number of correction procedures that can reduce the number of false positives, and the challenges associated with these correction procedures.Entities:
Keywords: computational biology; human; meta-research; multiple comparison correction; multiple comparisons; neuroscience; open data; sequential testing; systems biology
Mesh:
Year: 2020 PMID: 32425159 PMCID: PMC7237204 DOI: 10.7554/eLife.53498
Source DB: PubMed Journal: Elife ISSN: 2050-084X Impact factor: 8.140