| Literature DB >> 32419687 |
Philip J Batterham1, Matthew Sunderland2, Natacha Carragher3, Alison L Calear1.
Abstract
BACKGROUND: There are few very brief measures that accurately identify multiple common mental disorders. AIMS: The aim of this study was to develop and assess the psychometric properties of a new composite measure to screen for five common mental disorders.Entities:
Keywords: Screening; anxiety; assessment; depression
Year: 2020 PMID: 32419687 PMCID: PMC7331084 DOI: 10.1192/bjo.2020.37
Source DB: PubMed Journal: BJPsych Open ISSN: 2056-4724
Characteristics of the development and validation samples
| Development sample ( | Validation sample ( | ||||||
|---|---|---|---|---|---|---|---|
| (%) | (%) | ||||||
| Age group, | 129.49 | ||||||
| 18–25 years | 371 | (11.7) | 718 | (19.8) | |||
| 26–35 years | 277 | (8.7) | 443 | (12.2) | |||
| 36–45 years | 506 | (15.9) | 539 | (14.9) | |||
| 46–55 years | 830 | (26.1) | 738 | (20.4) | |||
| 56–65 years | 842 | (26.5) | 815 | (22.5) | |||
| 66 years or older | 349 | (11.0) | 365 | (10.1) | |||
| Prefer not to answer | 0 | (0.0) | 2 | (0.1) | |||
| Gender, | 37.60 | ||||||
| Male | 648 | (20.4) | 689 | (19.0) | |||
| Female | 2527 | (79.6) | 2890 | (79.8) | |||
| Other | 0 | (0.0) | 30 | (0.8) | |||
| Prefer not to answer | 0 | (0.0) | 11 | (0.3) | |||
| Education, | 145.47 | ||||||
| High school or less | 382 | (12.0) | 254 | (7.0) | |||
| High school graduate | 440 | (13.9) | 528 | (14.6) | |||
| Certificate/diploma/associate degree | 963 | (30.3) | 803 | (22.2) | |||
| Bachelor degree | 630 | (19.8) | 904 | (25.0) | |||
| Postgraduate degree | 747 | (23.5) | 1123 | (31.0) | |||
| Prefer not to answer | 13 | (0.4) | 8 | (0.2) | |||
| Employment status, | 27.88 | ||||||
| Full time | 856 | (27.0) | 1054 | (29.1) | |||
| Part time/casual | 819 | (25.8) | 1067 | (29.5) | |||
| Unemployed | 383 | (12.1) | 430 | (11.9) | |||
| Not working (study/leave/retired) | 1070 | (33.7) | 1024 | (28.3) | |||
| Prefer not to answer | 47 | (1.5) | 45 | (1.2) | |||
| Location, | 41.31 | ||||||
| Metropolitan area (capital city) | 1421 | (44.8) | 1891 | (52.2) | |||
| Regional area (other city/town) | 1279 | (40.3) | 1308 | (36.1) | |||
| Rural or remote area | 475 | (15.0) | 421 | (11.6) | |||
| Language spoken at home, | 2.62 | 0.270 | |||||
| English only | 2962 | (93.3) | 3344 | (92.4) | |||
| English and another language | 199 | (6.3) | 262 | (7.2) | |||
| Another language only | 14 | (0.4) | 14 | (0.4) | |||
| Met clinical criteria for MDD, | 362 | (11.4) | 309 | (8.5) | 15.61 | ||
| Met clinical criteria for GAD, | 645 | (20.3) | 805 | (22.2) | 3.73 | 0.054 | |
| Met clinical criteria for SAD, | 551 | (17.4) | 529 | (14.6) | 9.51 | ||
| Met clinical criteria for panic disorder, | 186 | (5.9) | 190 | (5.2) | 1.20 | 0.273 | |
| Met clinical criteria for PTSD, | 391 | (12.3) | 410 | (11.3) | 1.59 | 0.207 | |
| Met criteria for any of these disorders, | 1135 | (35.7) | 1229 | (34.0) | 2.33 | 0.127 | |
| Distress Questionnaire-5, mean (s.d.) | 11.48 | (5.10) | 10.86 | (4.81) | 5.16 | ||
| Kessler-10, mean (s.d.) | 11.90 | (8.90) | 11.86 | (8.79) | 0.21 | 0.835 | |
MDD, major depressive disorder; GAD, generalised anxiety disorder; SAD: social anxiety disorder; PTSD: post-traumatic stress disorder.
Bold values indicate P < 0.05.
Mean (s.d.) and 95% CI for items included in the composite screener, based on presence or absence of the disorder of interest
| Disorder of interest, absent | Disorder of interest, present | |||||
|---|---|---|---|---|---|---|
| 2813 | 363 | |||||
| MDD subscreener, mean (s.d.) 95% CI | ||||||
| I felt depressed | 2.34 | (1.17) | 2.30–2.39 | 4.22 | (0.75) | 4.14–4.29 |
| I felt hopeless | 2.02 | (1.14) | 1.97–2.06 | 3.94 | (0.92) | 3.84–4.03 |
| I felt that nothing could cheer me up | 1.85 | (1.10) | 1.81–1.89 | 3.83 | (0.91) | 3.73–3.92 |
| I felt that I had nothing to look forward to | 2.00 | (1.19) | 1.96–2.05 | 3.98 | (0.94) | 3.89–4.08 |
| 2530 | 645 | |||||
| GAD subscreener, mean (s.d.) 95% CI | ||||||
| I felt anxious | 2.17 | (1.02) | 2.13–2.21 | 3.63 | (0.91) | 3.56–3.70 |
| I felt worried | 2.23 | (1.00) | 2.19–2.27 | 3.65 | (0.85) | 3.59–3.72 |
| My worries overwhelmed me | 1.86 | (1.01) | 1.82–1.90 | 3.42 | (0.97) | 3.35–3.50 |
| Many situations made me worry | 1.91 | (1.03) | 1.87–1.95 | 3.46 | (0.97) | 3.39–3.54 |
| 3091 | 529 | |||||
| SAD subscreener, mean (s.d.) 95% CI | ||||||
| I felt nervous during social situations | 2.44 | (1.08) | 2.40–2.48 | 4.09 | (0.75) | 4.03–4.15 |
| My fear of social situations was distressing | 1.80 | (1.00) | 1.76–1.84 | 3.69 | (0.95) | 3.61–3.77 |
| I was unable to relax during social situations | 2.15 | (1.07) | 2.12–2.19 | 3.85 | (0.89) | 3.78–3.93 |
| I felt tense about mixing in a group | 2.29 | (1.10) | 2.25–2.33 | 4.01 | (0.87) | 3.93–4.08 |
| 3430 | 190 | |||||
| Panic disorder subscreener, mean (s.d.) 95% CI | ||||||
| I felt afraid of certain activities because I feared having a panic attack | 1.64 | (0.97) | 1.61–1.67 | 3.05 | (1.12) | 2.89–3.21 |
| I had a sudden unexpected period of intense fear, anxiety or discomfort | 2.06 | (1.06) | 2.02–2.09 | 3.44 | (0.86) | 3.32–3.56 |
| I felt terrified, my heart raced and I thought I might be dying | 1.42 | (0.78) | 1.40–1.45 | 2.68 | (1.04) | 2.53–2.83 |
| I worried about having an unexpected anxiety spell or panic attack | 1.65 | (0.99) | 1.62–1.68 | 3.10 | (1.08) | 2.95–3.25 |
| 3210 | 410 | |||||
| PTSD subscreener, mean (s.d.) 95% CI | ||||||
| I could not feel close to others because of a trauma | 1.51 | (0.91) | 1.48–1.54 | 3.11 | (1.23) | 2.99–3.23 |
| I felt cut off and isolated from other people because of a trauma | 1.53 | (0.94) | 1.50–1.56 | 3.23 | (1.26) | 3.11–3.35 |
| I did not enjoy the company of others because of a trauma | 1.45 | (0.86) | 1.42–1.48 | 2.99 | (1.25) | 2.87–3.11 |
| I felt on edge and distressed when thinking about a trauma | 1.63 | (1.00) | 1.60–1.66 | 3.37 | (1.24) | 3.25–3.49 |
MDD, major depressive disorder; GAD, generalised anxiety disorder; SAD: social anxiety disorder; PTSD: post-traumatic stress disorder.
Comparison of area under the curve for new 4-item subscreeners in comparison with existing measures of general psychological distress
| Disorder | RMT20 subscreener AUC (95% CI) | K10 AUC (95% CI) | DQ5 AUC (95% CI) | RMT20 | RMT20 | ||
|---|---|---|---|---|---|---|---|
| Major depression (D) | 0.917 (0.905–0.930) | 0.900 (0.887–0.913) | 0.898 (0.885–0.912) | 6.88 | 8.65 | ||
| Generalised anxiety (D) | 0.889 (0.876–0.901) | 0.849 (0.835–0.864) | 0.880 (0.867–0.894) | 32.57 | 2.72 | 0.099 | |
| Social anxiety (V) | 0.916 (0.905–0.928) | 0.844 (0.827–0.861) | 0.868 (0.853–0.883) | 94.11 | 57.00 | ||
| Panic disorder (V) | 0.878 (0.859–0.896) | 0.807 (0.780–0.835) | 0.810 (0.783–0.837) | 35.63 | 38.38 | ||
| PTSD (V) | 0.863 (0.844–0.883) | 0.820 (0.800–0.839) | 0.815 (0.796–0.835) | 14.18 | 17.43 | ||
(D), data from the development sample (n = 3175); (V), data from the validation sample (n = 3620); PTSD: post-traumatic stress disorder; AUC, area under the receiver operating characteristic curve; K10, Kessler-10; DQ5, Distress Questionnaire-5.
χ tests have one degree of freedom; bold values indicate P < 0.05.
Performance of the subscreeners at selected cut-points
| RMT20 | K10 ≥ 25 | DQ5 ≥ 14 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Disorder | Items | Range | Cronbach α | Cut-point | Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) |
| Major depression (D) | 4 | 4–20 | 0.944 | ≥13 | 89.5 (85.9–92.5) | 82.6 (81.2–84.0) | 92.8 (89.7–95.3) | 71.5 (69.8–73.1) | 86.7 (82.8–90.0) | 78.2 (76.6–79.7) |
| Generalised anxiety (D) | 4 | 4–20 | 0.925 | ≥11 | 88.6 (86.0–91.0) | 73.4 (71.6–75.1) | 79.5 (76.2–82.6) | 75.3 (73.5–76.9) | 76.9 (73.5–80.1) | 82.9 (81.4–84.4) |
| Social anxiety (V) | 4 | 4–20 | 0.930 | ≥12 | 93.2 (90.7–95.2) | 76.5 (75.0–78.0) | 80.7 (77.1–84.0) | 73.3 (71.7–74.9) | 83.4 (79.9–86.4) | 73.6 (72.0–75.2) |
| Panic disorder (V) | 4 | 4–20 | 0.891 | ≥9 | 87.4 (81.8–91.7) | 74.6 (73.1–76.0) | 76.8 (70.2–82.6) | 67.8 (66.2–69.3) | 83.1 (77.1–88.2) | 68.0 (66.4–69.5) |
| PTSD (V) | 4 | 4–20 | 0.959 | ≥8 | 84.6 (80.8–88.0) | 74.4 (72.8–75.9) | 78.3 (74.0–82.2) | 71.0 (69.4–72.6) | 77.6 (73.2–81.5) | 70.8 (69.1–72.3) |
(D), based on data from the development sample (n = 3175); (V), based on data from the validation sample (n = 3620); PTSD: post-traumatic stress disorder.