| Literature DB >> 32416002 |
Beatriz Lozano-Torres1,2,3,4, Juan F Blandez1,2,4, Irene Galiana1,2, Alba García-Fernández3, María Alfonso1, María D Marcos1,2,3,4, Mar Orzáez2,5, Félix Sancenón1,2,3,4, Ramón Martínez-Máñez1,2,3,4.
Abstract
In vivo detection of cellular senescence is accomplished by using mesoporous silica nanoparticles loaded with the NIR-FDA approved Nile blue (NB) dye and capped with a galactohexasaccharide (S3). NB emission at 672 nm is highly quenched inside S3, yet a remarkable emission enhancement is observed upon cap hydrolysis in the presence of β-galactosidase and dye release. The efficacy of the probe to detect cellular senescence is tested in vitro in melanoma SK-Mel-103 and breast cancer 4T1 cells and in vivo in palbociclib-treated BALB/cByJ mice bearing breast cancer tumor.Entities:
Keywords: NIR probes; Nile blue; in vivo detection; mesoporous nanoparticles; senescence
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Year: 2020 PMID： 32416002 DOI： 10.1002/anie.202004142
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336