| Literature DB >> 32414818 |
Duah Dwomoh1, Kofi Agyabeng2, Kwame Agbeshie3, Gabriel Incoom4, Priscilla Nortey5, Alfred Yawson6, Samuel Bosomprah2.
Abstract
OBJECTIVE: Despite the huge financial investment in the free maternal healthcare policy (FMHCP) by the Governments of Ghana and Burkina Faso, no study has quantified the impact of FMHCP on the relative reduction in neonatal and infant mortality rates using a more rigorous matching procedure with the difference in differences (DID) analysis. This study used several rounds of publicly available population-based complex survey data to determine the impact of FMHCP on neonatal and infant mortality rates in these two countries.Entities:
Keywords: free maternal healthcare policy; infant mortality; neonatal mortality; public health
Mesh:
Year: 2020 PMID: 32414818 PMCID: PMC7232624 DOI: 10.1136/bmjopen-2019-033356
Source DB: PubMed Journal: BMJ Open ISSN: 2044-6055 Impact factor: 2.692
Trend of neonatal and infant mortality between countries with and without FMHCP and description of the study participants: 2007/2008–2013/2014
| Total % | Intervention: FMHCP implementation | Rao–Scot χ2 | ||
| No FMHCP %* | FMHCP %* | |||
| All-cause mortality in 5 years preceding the survey (95% CI) | 9.2 (8.9–9.5) | 9.8 (9.5–10.1) | 6.2 (5.9–6.6) | 159.60*** |
| All-cause neonatal deaths in 5 years preceding the survey (95% CI) | 3.5 (3.3–3.6) | 3.1 (2.9–3.3) | 0.4 (0.3–0.4) | 76.70*** |
| All-cause infant deaths in 5 years preceding the survey (95% CI) | 6.7 (6.5–7.0) | 7.3 (7.1–7.6) | 4.0 (3.6–4.3) | 168.40*** |
| Sex of household head | 114.03*** | |||
| Male | 97 430 (88.4) | 70 247 (83.4) | 27 183 (16.6) | |
| Female | 13 318 (11.6) | 9740 (74.3) | 3578 (25.7) | |
| Wealth quintile | 2.00 | |||
| Poorest | 26 597 (23.3) | 19 264 (82.9) | 7333 (17.1) | |
| Poorer | 25 526 (22.7) | 18 862 (83.3) | 6664 (16.7) | |
| Middle | 22 913 (19.4) | 16 412 (81.4) | 6501 (18.6) | |
| Richer | 20 303 (18.2) | 14 198 (80.7) | 6105 (19.3) | |
| Richest | 15 409 (16.5) | 11 251 (82.9) | 4158 (17.1) | |
| Household size | 20.26*** | |||
| 1–4 | 26 784 (25.8) | 19 215 (79.8) | 7569 (20.2) | |
| 5–7 | 45 709 (41.5) | 33 951 (82.9) | 11 758 (17.1) | |
| 8+ | 38 255 (32.8) | 26 821 (83.5) | 11 434 (16.5) | |
| Access to improved water | 121.32*** | |||
| Improved | 89 000 (80.4) | 61 284 (80.1) | 28 049 (19.9) | |
| Unimproved | 21 000 (19.6) | 18 676 (91.4) | 2711 (8.6) | |
| Missing | 28 (0.01) | 27 (98.4) | 1 (1.6) | |
| Access to an improved toilet facility | 195.72*** | |||
| Improved, not shared | 26 000 (27.0) | 22 493 (91.7) | 3817 (8.3) | |
| Improved, shared | 21 000 (22.5) | 13 047 (71.0) | 7762 (29.0) | |
| Unimproved | 63 000 (50.1) | 44 120 (82.4) | 19 095 (17.6) | |
| Missing | 414 (0.4) | 327 (81.2) | 87 (18.8) | |
| Place of residence | 0.61 | |||
| Urban | 32 627 (32.2) | 25 035 (82.9) | 7592 (17.1) | |
| Rural | 78 121 (67.8) | 54 952 (82.0) | 23 169 (18.0) | |
| Household ownership of bednet | 1013.52*** | |||
| No bednet | 43 000 (46.4) | 36 880 (92.4) | 6015 (7.6) | |
| Bednet | 68 000 (53.6) | 43 062 (73.6) | 24 746 (26.5) | |
| Missing | 45 (0.06) | 45 (100.0) | 0 (0.0) | |
| Mothers’ current age | 11.10*** | |||
| <18 years | 3558 (3.3) | 2803 (86.5) | 755 (13.5) | |
| 18–34 years | 80 000 (71.5) | 58 000 (82.3) | 22 000 (17.7) | |
| 35+ | 27 000 (25.2) | 20 000 (81.8) | 7727 (18.2) | |
| Mothers’ education | 44.98*** | |||
| None | 53 000 (46.5) | 32 000 (79.4) | 21 000 (20.6) | |
| Primary | 29 000 (23.2) | 24 000 (86.6) | 4475 (13.4) | |
| JHS | 25 000 (25.5) | 20 000 (81.7) | 4686 (18.3) | |
| Secondary or higher | 4241 (4.8) | 3882 (92.4) | 359 (7.6) | |
| Missing | 16 (0.01) | 11 (64.6) | 5 (35.4) | |
| Birth order | 271.39*** | |||
| 1st birth | 24 000 (21.1) | 16 000 (75.8) | 8167 (24.2) | |
| 2nd birth | 21 000 (18.9) | 14 000 (76.1) | 7351 (23.9) | |
| 3rd birth | 17 000 (15.2) | 12 000 (83.1) | 4386 (16.9) | |
| 4th birth | 49 000 (44.8) | 38 000 (87.7) | 11 000 (12.3) | |
| Multiple births | 10.19** | |||
| Single | 110 000 (96.4) | 77 000 (82.4) | 30 000 (17.6) | |
| Multiple | 3994 (3.6) | 2750 (79.1) | 1244 (20.9) | |
| Child mortality estimate per country | ||||
| Country | Year of survey | NMR per 1000 live births | IMR per 1000 live births | Cumulative incidence |
| Burkina Faso | 2003 | 31 | 81 | 67.9 |
| 2010 | 28 | 65 | 44.3 | |
| 2014 | 27.3 | 61.4 | 23.9 | |
| Ghana | 2003 | 43 | 64 | 30.0 |
| 2008 | 30 | 50 | 28.5 | |
| 2014 | 29 | 41 | 15.1 | |
| Nigeria | 2003 | 48 | 100 | 63.2 |
| 2008 | 40 | 75 | 50.6 | |
| 2013 | 37 | 69 | 36.8 | |
| Zambia | 2001–2002 | 37 | 95 | 70.5 |
| 2007 | 34 | 70 | 44.7 | |
| 2014 | 24 | 45 | 26.5 | |
P value notation: ***p<0.001, **p<0.01, *p<0.05.
Access to improved toilet facilities had a missing observation of 0.4%.
*% represents row percentages.
FMHCP, free maternal healthcare policy; IMR, infant mortality rate; NMR, neonatal mortality rate.
Figure 1KMSE at varying time points of FMHCP implementation. BF, Burkina Faso; FMHCP, free maternal healthcare policy; GHA, Ghana; KMSE, Kaplan–Meier survival estimate; NIG, Nigeria; ZAM, Zambia.
Figure 2Balancing the diagnostic test of the Kernel-based propensity score matching. FMHCP, free maternal healthcare policy.
Test of parallel trends assumption: risk of neonatal and infant mortality prior to free maternal healthcare policy implementation (2001–2008): modified Poisson model with robust SE on the unmatched sample
| Covariates | Neonatal mortality: 2000–2008 | Infant mortality: 2000–2008 | ||
| uRR (95% CI) | aRR (95% CI) | uRR (95% CI) | aRR (95% CI) | |
| Time baseline: 2008 | ref | ref | ref | ref |
| End-line: 2014 | 0.86* (0.75 to 0.99) | 0.88 (0.75 to 1.02) | 0.83*** (0.76 to 0.91) | 0.84** (0.76 to 0.94) |
| Intervention | ||||
| No FMHCP | ref | ref | ref | |
| FMHCP-assumed it exited | 0.85 (0.72 to 1.01) | 0.89 (0.71 to 1.11) | 0.94 (0.84 to 1.05) | 0.92 (0.79 to 1.07) |
| Time*FMHCP | 0.92 (0.74 to 1.15) | 0.91 (0.71 to 1.16) | 0.93 (0.81 to 1.08) | 0.91 (0.78 to 1.08) |
| Sex of household head | ||||
| Male | ref | ref | ||
| Female | 0.90 (0.73 to 1.11) | 0.89 (0.76 to 1.03) | ||
| Mothers’ current age | ||||
| <18 years | ref | ref | ||
| 18–34 years | 0.90 (0.78 to 1.03) | 0.91 (0.82 to 1.00) | ||
| 35+ | 2.33* (1.02 to 5.30) | 2.40* (1.10 to 5.26) | ||
| Place of residence | ||||
| Urban | ref | ref | ||
| Rural | 1.35*** (1.14 to 1.60) | 1.29*** (1.14 to 1.45) | ||
| Household size | ||||
| 1–4 | ref | ref | ||
| 5–7 | 0.48*** (0.40 to 0.57) | 0.49*** (0.43 to 0.55) | ||
| 8+ | 0.43*** (0.35 to 0.52) | 0.43*** (0.37 to 0.49) | ||
| Access to improved water | ||||
| Improved | ref | ref | ||
| Unimproved | 1.08 (0.92 to 1.27) | 1.13* (1.01 to 1.26) | ||
| Access to an improved toilet facility | ||||
| Improved, not shared | ref | ref | ||
| Improved, shared | 0.81* (0.66 to 0.98) | 0.76*** (0.66 to 0.87) | ||
| Unimproved | 0.85 (0.72 to 1.01) | 0.86* (0.77 to 0.97) | ||
| Mothers’ education | ||||
| None | ref | ref | ||
| Primary | 1.01 (0.84 to 1.2) | 0.94 (0.83 to 1.06) | ||
| JHS | 0.84 (0.69 to 1.02) | 0.73*** (0.63 to 0.83) | ||
| Secondary or higher | 0.93 (0.59 to 1.44) | 0.55** (0.39 to 0.78) | ||
| Birth order | ||||
| 1st birth | ref | ref | ||
| 2nd birth | 0.70** (0.57 to 0.86) | 0.83* (0.71 to 0.98) | ||
| 3rd birth | 0.71** (0.55 to 0.9) | 0.99 (0.84 to 1.17) | ||
| 4th birth | 1.03 (0.84 to 1.26) | 1.20* (1.04 to 1.39) | ||
| Multiple births | ||||
| Single | ref | ref | ||
| Multiple | 5.31*** (4.26 to 6.62) | 3.70*** (3.11 to 4.40) | ||
| Household ownership of bednet | ||||
| No bednet | ref | ref | ||
| Bednet | 0.91 (0.78 to 1.05) | 0.95 (0.86 to 1.05) | ||
| Country fixed effect | Yes | Yes | Yes | Yes |
P value notations: ***p<0.001, **p<0.01, *p<0.05.
With respect to Burkina Faso, 2010 demographic health survey data were used since they did not conduct any survey in 2008.
aRR, adjusted relative risk; FMHCP, free maternal healthcare policy; JHS, junior high school; uRR, unadjusted relative risk.
Impact of the free maternal healthcare policy on neonatal mortality: Kernel-based propensity score matching with the difference in differences analysis using modified Poisson with robust SE
| Sensitivity analysis based on different model specification | |||||||
| Modified Poisson | Cox-proportional hazard model: clustering, weighting and stratification were adjusted | Logistic regression | Probit regression | Modified Poisson | |||
| No Kernel matching | With Kernel matching based on PS | With Kernel matching based on PS | With Kernel matching based on PS | With Kernel matching based on PS | ATET weighting and PS-IPTW | ATE weighting and PS | |
| aRR (95% CI) | aRR (95% CI) | aHR (95% CI) | aOR (95% CI) | β (95% CI) | aRR (95% CI) | aRR (95% CI) | |
| Time | |||||||
| Baseline: 2008 | ref | ref | ref | ref | ref | ref | ref |
| End-line: 2014 | 0.92 (0.82 to 1.03) | 0.63* (0.42 to 0.96) | 0.62* (0.42 to 0.91) | 0.59 (0.33 to 1.07) | −0.35* (−0.69 to 0.01) | 0.61** (0.46 to 0.81) | 0.67** (0.51 to 0.86) |
| Intervention | |||||||
| No FMHCP | ref | ref | ref | ref | ref | ref | ref |
| FMHCP | 0.66*** (0.53 to 0.83) | 0.94 (0.74 to 1.19) | 0.96 (0.77 to 1.19) | 0.95 (0.62 to 1.47) | −0.04 (−0.28 to 0.2) | −0.81 (0.78 to 1.11) | 0.93 (0.82 to 1.07) |
| Time*FMHCP | 0.56*** (0.43 to 0.73) | 0.55*** (0.40 to 0.76) | 0.55*** (0.40 to 0.74) | 0.44* (0.22 to 0.88) | −0.41* (−0.79 to 0.02) | 0.57*** (0.42 to 0.77) | 0.71 (0.46 to 1.08) |
| Sex of household head | |||||||
| Male | ref | ref | ref | ref | ref | ref | ref |
| Female | 0.85* (0.73 to 0.99) | 0.73* (0.55 to 0.97) | 0.81 (0.63 to 1.04) | 1.08 (0.67 to 1.74) | 0.02 (−0.24 to 0.29) | −1.99* (0.65 to 1) | 0.78* (0.63, 0.95) |
| Mothers’ current age | |||||||
| <18 years | ref | ref | ref | ref | ref | ref | ref |
| 18–34 years | 0.43*** (0.35 to 0.54) | 0.51** (0.35 to 0.75) | 1.01 (0.71 to 1.43) | 2.69** (1.40 to 5.18) | 0.59** (0.21 to 0.98) | 3.99*** (0.39 to 0.72) | 0.53*** (0.39 to 0.71) |
| 35+ | 0.46*** (0.36 to 0.59) | 0.55** (0.35 to 0.86) | 1.29 (0.85 to 1.95) | 6.7*** (3.12 to 14.38) | 1.11*** (0.67 to 1.56) | −3.17** (0.39 to 0.8) | 0.5*** (0.35 to 0.72) |
| Place of residence | |||||||
| Urban | ref | ref | ref | ref | ref | ref | ref |
| Rural | 1.24** (1.08 to 1.42) | 1.23 (0.87 to 1.74) | 1.2 (0.88 to 1.64) | 1.04 (0.65 to 1.65) | 0.05 (−0.22 to 0.32) | 1.94 (1.00 to 1.96) | 1.21 (0.84 to 1.74) |
| Wealth quintile | |||||||
| Poorest | ref | ref | ref | ref | ref | ref | ref |
| Poorer | 1.01 (0.89 to 1.15) | 1.04 (0.86 to 1.27) | 1.03 (0.86 to 1.24) | 0.81 (0.53 to 1.23) | −0.1 (−0.34 to 0.14) | 0.72 (0.89 to 1.28) | 0.98 (0.79 to 1.22) |
| Middle | 0.86 (0.74 to 1.01) | 0.93 (0.73 to 1.18) | 0.96 (0.77 to 1.19) | 0.93 (0.56 to 1.54) | −0.03 (−0.32 to 0.27) | 0.2 (0.82 to 1.27) | 0.89 (0.69 to 1.16) |
| Richer | 0.91 (0.75 to 1.10) | 0.83 (0.61 to 1.13) | 0.87 (0.65 to 1.16) | 0.88 (0.43 to 1.79) | −0.06 (−0.47 to 0.34) | −0.64 (0.70 to 1.20) | 0.86 (0.61 to 1.2) |
| Richest | 0.86 (0.68 to 1.11) | 0.95 (0.56 to 1.61) | 1.01 (0.62 to 1.62) | 1.04 (0.46 to 2.34) | 0.05 (−0.41 to 0.52) | −0.87 (0.60 to 1.22) | 0.88 (0.55 to 1.42) |
| Household size | |||||||
| 1–4 | ref | ref | ref | ref | ref | ref | ref |
| 5–7 | 0.42*** (0.37 to 0.49) | 0.46*** (0.38 to 0.56) | 0.55*** (0.45 to 0.65) | 0.49** (0.31 to 0.78) | −0.41** (−0.67 to 0.15) | 8.18*** (0.38 to 0.55) | 0.42*** (0.34 to 0.51) |
| 8+ | 0.35*** (0.3 to 0.4) | 0.41*** (0.33 to 0.52) | 0.48*** (0.39 to 0.59) | 0.33*** (0.22 to 0.49) | −0.64*** (−0.87 to 0.41) | 8.67*** (0.32 to 0.49) | 0.38*** (0.31 to 0.46) |
| Access to improved water | |||||||
| Improved | ref | ref | ref | ref | ref | ref | ref |
| Unimproved | 1.06 (0.93 to 1.21) | 1.06 (0.87 to 1.3) | 1.06 (0.89 to 1.27) | 1.28 (0.88 to 1.88) | 0.15 (−0.07 to 0.36) | 0.02 (0.82 to 1.22) | 1.02 (0.82 to 1.28) |
| Access to an improved toilet facility | |||||||
| Improved, not shared | ref | ref | ref | ref | ref | ref | ref |
| Improved, shared | 0.84* (0.72 to 0.97) | 0.97 (0.78 to 1.22) | 0.97 (0.79 to 1.18) | 1.08 (0.72 to 1.63) | 0.04 (−0.20 to 0.28) | −0.43 (0.78 to 1.17) | 0.90 (0.70 to 1.16) |
| Unimproved | 0.84** 0.75 to 0.94) | 0.92 (0.76 to 1.11) | 0.92 (0.78 to 1.10) | 1.10 (0.76 to 1.59) | 0.05 (−0.15 to 0.26) | −1.00 (0.77 to 1.09) | 0.86 (0.72 to 1.04) |
| Mothers’ education | |||||||
| None | ref | ref | ref | ref | ref | ref | ref |
| Primary | 1.05 (0.93 to 1.20) | 0.98 (0.78 to 1.23) | 0.97 (0.78 to 1.20) | 0.78 (0.52 to 1.18) | −0.14 (−0.38 to 0.10) | −0.80 (0.76 to 1.12) | 0.99 (0.79 to 1.25) |
| JHS | 0.94 (0.80 to 1.10) | 0.93 (0.69 to 1.25) | 0.86 (0.65 to 1.13) | 0.62 (0.35 to 1.10) | −0.25 (−0.57 to 0.06) | −1.01 (0.72 to 1.11) | 0.96 (0.80 to 1.16) |
| Secondary or higher | 0.75 (0.55 to 1.03) | 0.81 (0.46 to 1.41) | 0.71 (0.42 to 1.21) | 0.20*** (0.08 to 0.47) | −0.92*** (−1.44 to 0.41) | −1.37 (0.45 to 1.15) | 0.79 (0.43 to 1.46) |
| Birth order | |||||||
| 1st birth | ref | ref | ref | ref | ref | ref | ref |
| 2nd birth | 0.94 (0.82 to 1.09) | 0.69** (0.54 to 0.89) | 0.62*** (0.49 to 0.77) | 0.52* (0.30 to 0.89) | −0.38* (−0.67 to 0.08) | −2.89** (0.61 to 0.91) | 0.74* (0.59 to 0.93) |
| 3rd birth | 0.98 (0.82 to 1.18) | 0.89 (0.66 to 1.2) | 0.73* (0.56 to 0.97) | 0.60 (0.34 to 1.07) | −0.29 (−0.61 to 0.03) | −0.24 (0.75 to 1.25) | 0.88 (0.67 to 1.15) |
| 4th birth | 1.32** (1.12 to 1.56) | 1.18 (0.90 to 1.56) | 0.87 (0.67 to 1.12) | 0.46** (0.26 to 0.81) | −0.44** (−0.76 to 0.12) | 2.21* (1.03 to 1.58) | 1.29* (1.00 to 1.65) |
| Multiple births | |||||||
| Single | |||||||
| Multiple | 5.84*** (4.97 to 6.86) | 5.58*** (4.25 to 7.32) | 4.73*** (3.78 to 5.92) | 6.17*** (2.47 to 15.41) | 0.96*** (0.52 to 1.4) | 15.61*** (4.74 to 7.41) | 5.58*** (4.37 to 7.12) |
| Household ownership of bednet | |||||||
| No bednet | |||||||
| Bednet | 0.98 (0.88 to 1.09) | 0.96 (0.82 to 1.12) | 0.96 (0.83 to 1.11) | 1.01 (0.74 to 1.37) | 0.01 (−0.16 to 0.19) | −1.04 (0.79 to 1.07) | 0.93 (0.78 to 1.1) |
| Country fixed effect | Adjusted | Adjusted | Adjusted | Adjusted | Adjusted | Adjusted | Adjusted |
P value notations: ***p<0.001, **p<0.01, *p<0.05.
aHR, adjusted hazard ratio; aOR, adjusted odds ratio; aRR, adjusted relative risk; ATE, average treatment effect; ATET, average treatment effect on the treated; FMHCP, free maternal healthcare policy; IPTW, inverse probability of treatment weighting; PS, propensity scores; ref, reference category.
Impact of the free maternal healthcare policy on infant mortality: Kernel-based propensity score matching with the difference in differences analysis using modified Poisson with robust SE
| Sensitivity analysis based on different model specification | |||||||
| Modified Poisson | Cox-proportional hazard model: clustering, weighting and stratification were adjusted | Logistic regression | Probit regression | Modified Poisson | |||
| No Kernel matching with PSM | With Kernel matching with PSM | With Kernel matching PSM | With Kernel matching with PSM | With Kernel matching with PSM | ATET weighting using PSM-IPTW | ATE weighting using PSM | |
| aRR (95% CI) | aRR (95% CI) | aHR (95% CI) | aOR (95% CI) | β (95% CI) | aRR (95% CI) | aRR (95% CI) | |
| Time | |||||||
| Baseline: 2008 | ref | ref | ref | ref | ref | ref | ref |
| End-line: 2014 | 0.79*** (0.73 to 0.86) | 0.62*** (0.48 to 0.8) | 0.62*** (0.49 to 0.78) | 0.45*** (0.35 to 0.58) | −0.45*** (−0.59 to 0.32) | 0.64*** (0.53 to 0.78) | 0.77** (0.64 to 0.91) |
| Intervention | |||||||
| No FMHCP | ref | ref | ref | ref | ref | ref | ref |
| FMHCP | 0.72*** (0.62 to 0.84) | 0.87 (0.74 to 1.03) | 0.89 (0.77 to 1.04) | 0.86 (0.72 to 1.02) | −0.09 (−0.19 to 0.01) | 0.84* (0.74 to 0.96) | 0.83*** (0.76 to 0.92) |
| Time*FMHCP | 0.49*** (0.39 to 0.61) | 0.46*** (0.36 to 0.59) | 0.45*** (0.35 to 0.57) | 0.43*** (0.33 to 0.56) | −0.49*** (−0.64 to 0.34) | 0.48*** (0.37 to 0.6) | 0.55** (0.39 to 0.77) |
| Sex of household head | |||||||
| Male | ref | ref | ref | ref | ref | ref | ref |
| Female | 0.88* (0.78 to 0.98) | 0.75** (0.61 to 0.92) | 0.81* (0.68 to 0.98) | 0.96 (0.79 to 1.17) | −0.02 (−0.13 to 0.09) | 0.87 (0.74 to 1.02) | 0.88 (0.75 to 1.02) |
| Mothers’ current age | |||||||
| <18 years | ref | ref | ref | ref | ref | ref | ref |
| 18–34 years | 0.49*** (0.41 to 0.58) | 0.49*** (0.37 to 0.66) | 0.86 (0.65 to 1.14) | 3.1*** (2.2 to 4.38) | 0.63*** (0.44 to 0.81) | 0.49*** (0.38 to 0.63) | 0.59*** (0.46 to 0.75) |
| 35+ | 0.49*** (0.4 to 0.59) | 0.47*** (0.33 to 0.66) | 0.95 (0.69 to 1.31) | 5.74*** (3.92 to 8.4) | 0.96*** (0.75 to 1.17) | 0.46*** (0.35 to 0.61) | 0.52*** (0.39 to 0.68) |
| Place of residence | |||||||
| Urban | ref | ref | ref | ref | ref | ref | ref |
| Rural | 1.16** (1.05 to 1.29) | 1.2 (0.96 to 1.5) | 1.19 (0.97 to 1.46) | 1.18 (0.96 to 1.45) | 0.09 (−0.03 to 0.2) | 1.14 (0.96 to 1.36) | 1.13 (0.89 to 1.45) |
| Wealth quintile | |||||||
| Poorest | ref | ref | ref | ref | ref | ref | ref |
| Poorer | 1.02 (0.92 to 1.12) | 1.01 (0.87 to 1.17) | 1 (0.87 to 1.15) | 0.97 (0.81 to 1.16) | −0.02 (−0.12 to 0.08) | 1.04 (0.91 to 1.18) | 0.99 (0.86 to 1.15) |
| Middle | 0.88* (0.79 to 0.98) | 0.92 (0.77 to 1.11) | 0.95 (0.8 to 1.12) | 0.99 (0.8 to 1.23) | −0.01 (−0.13 to 0.11) | 0.92 (0.79 to 1.07) | 0.93 (0.78 to 1.11) |
| Richer | 0.86* (0.75 to 0.99) | 0.91 (0.7 to 1.19) | 0.95 (0.74 to 1.21) | 0.93 (0.68 to 1.28) | −0.03 (−0.2 to 0.14) | 0.89 (0.72 to 1.09) | 0.8* (0.64 to 1) |
| Richest | 0.69*** (0.57 to 0.82) | 0.78 (0.54 to 1.12) | 0.81 (0.58 to 1.13) | 0.8 (0.57 to 1.11) | −0.14 (−0.32 to 0.05) | 0.68** (0.52 to 0.89) | 0.73 (0.5 to 1.06) |
| Household size | |||||||
| 1–4 | ref | ref | ref | ref | ref | ref | ref |
| 5–7 | 0.43*** (0.39 to 0.47) | 0.45*** (0.38 to 0.52) | 0.52*** (0.45 to 0.59) | 0.54*** (0.45 to 0.65) | −0.34*** (−0.44 to 0.24) | 0.46*** (0.4 to 0.52) | 0.43*** (0.37 to 0.5) |
| 8+ | 0.35*** (0.32 to 0.39) | 0.4*** (0.34 to 0.48) | 0.46*** (0.39 to 0.54) | 0.43*** (0.35 to 0.52) | −0.45*** (−0.55 to 0.34) | 0.42*** (0.36 to 0.49) | 0.38*** (0.33 to 0.45) |
| Access to improved water | |||||||
| Improved | ref | ref | ref | ref | ref | ref | ref |
| Unimproved | 1.05 (0.96 to 1.16) | 1.03 (0.89 to 1.19) | 1.02 (0.89 to 1.17) | 1.02 (0.88 to 1.17) | 0 (−0.07 to 0.08) | 0.99 (0.86 to 1.15) | 1.05 (0.9 to 1.22) |
| Access to an improved toilet facility | |||||||
| Improved, not shared | ref | ref | ref | ref | ref | ref | ref |
| Improved, shared | 0.87* (0.78 to 0.97) | 0.94 (0.79 to 1.1) | 0.94 (0.81 to 1.09) | 0.82* (0.69 to 0.97) | −0.11* (−0.2 to 0.01) | 0.97 (0.83 to 1.13) | 0.94 (0.78 to 1.13) |
| Unimproved | 0.88** (0.81 to 0.96) | 0.92 (0.8 to 1.05) | 0.93 (0.82 to 1.05) | 0.88 (0.75 to 1.02) | −0.07 (−0.15 to 0.02) | 0.93 (0.82 to 1.05) | 0.92 (0.79 to 1.06) |
| Mothers’ education | |||||||
| None | ref | ref | ref | ref | ref | ref | ref |
| Primary | 0.9* (0.82 to 0.99) | 0.82* (0.7 to 0.97) | 0.82** (0.71 to 0.95) | 0.69*** (0.58 to 0.83) | −0.21*** (−0.31 to 0.11) | 0.81** (0.71 to 0.93) | 0.89 (0.76 to 1.03) |
| JHS | 0.88* (0.78 to 0.98) | 0.83 (0.67 to 1.02) | 0.77** (0.64 to 0.94) | 0.54*** (0.43 to 0.67) | −0.35*** (−0.47 to 0.24) | 0.82* (0.69 to 0.97) | 0.87 (0.73 to 1.03) |
| Secondary or higher | 0.7** (0.56 to 0.89) | 0.78 (0.53 to 1.17) | 0.71 (0.48 to 1.04) | 0.38*** (0.24 to 0.58) | −0.55*** (−0.78 to 0.31) | 0.78 (0.53 to 1.14) | 0.69 (0.43 to 1.11) |
| Birth order | |||||||
| 1st birth | ref | ref | ref | ref | ref | ref | ref |
| 2nd birth | 1.03 (0.93 to 1.15) | 0.86 (0.72 to 1.03) | 0.77** (0.65 to 0.91) | 0.6*** (0.5 to 0.73) | −0.27*** (−0.38 to 0.17) | 0.94 (0.82 to 1.08) | 0.84* (0.71 to 1) |
| 3rd birth | 1.2** (1.05 to 1.37) | 1.13 (0.91 to 1.4) | 0.96 (0.79 to 1.17) | 0.65*** (0.52 to 0.81) | −0.24*** (−0.36 to 0.12) | 1.19 (1 to 1.43) | 1.08 (0.88 to 1.34) |
| 4th birth | 1.59*** (1.42 to 1.79) | 1.63*** (1.34 to 1.98) | 1.25* (1.05 to 1.5) | 0.7** (0.56 to 0.86) | −0.2** | 1.66*** (1.42 to 1.93) | 1.51*** (1.23 to 1.86) |
| Multiple births | |||||||
| Single | ref | ref | ref | ref | ref | ref | ref |
| Multiple | 4.37*** (3.86 to 4.95) | 3.95*** (3.16 to 4.95) | 3.57*** (2.96 to 4.3) | 3.59*** (2.75 to 4.67) | 0.72*** (0.57 to 0.87) | 4.24*** (3.58 to 5.03) | 4.43*** (3.71 to 5.29) |
| Household ownership of bednet | |||||||
| No bednet | ref | ref | ref | ref | ref | ref | ref |
| Bednet | 1.06 (0.98 to 1.14) | 0.98 (0.88 to 1.09) | 0.97 (0.88 to 1.08) | 0.99 (0.88 to 1.12) | −0.01 (−0.08 to 0.06) | 0.96 (0.86 to 1.06) | 0.94 (0.85 to 1.05) |
| Country fixed effect | Adjusted | Adjusted | Adjusted | Adjusted | Adjusted | Adjusted | Adjusted |
P value notations: ***p<0.001, **p<0.01, *p<0.05.
aHR, adjusted hazard ratio; aOR, adjusted odds ratio; aRR, adjusted relative risk; ATE, average treatment effect; ATET, average treatment effect on the treated; FMHCP, free maternal healthcare policy; IPTW, inverse probability of treatment weighting; PS, propensity scores.