OBJECTIVE: To investigate the clinicopathological characteristics and prognostic factors of early-stage breast cancer patients with indications for breast cancer susceptibility genes 1/2 (BRCA1/2) genetic testing in China. METHODS: Based on the indication criteria for BRCA genetic testing specified in the National Comprehensive Cancer Network (NCCN) clinical practice guidelines in oncology, genetic/familial high-risk assessment: Breast and ovarian (Version 2. 2019), a retrospective analysis was performed on patients with early-stage invasive breast cancer treated at Breast Disease Center, Peking University First Hospital between January 2008 and December 2016. Clinicopathological characteristics of all patients were analyzed, and prognoses were calculated using the Kaplan-Meier method and a Cox proportionate hazards model. RESULTS: A total of 906 early-stage breast cancer patients who had indications for BRCA genetic testing and had complete clinicopathological data and follow-up information were included in the study group, accounting for 34.7% of all breast cancer patients treated in Breast Disease Center, Peking University First Hospital during the study period. Compared with breast cancer patients without indications for BRCA genetic testing, the overall survival (OS) and disease-free survival (DFS) of patients with indications were not significantly different. In the study group, patients with premenopausal status, high T stage, lymph node positive, estrogen receptor (ER) negative, Ki-67>20% and presence of a vascular tumor thrombus had worse prognosis. There were more family histories of gastrointestinal cancer in patients with related indications than in patients without such indications. CONCLUSIONS: Single-center data showed that more than 30% of patients with early-stage breast cancer had indications for BRCA genetic testing. There was no prognostic difference in patients with or without indications for BRCA genetic testing. Premenopausal status, high T stage, lymph node positive, ER negative, Ki-67>20%, and presence of a vascular tumor thrombus were associated with poor prognosis.
OBJECTIVE: To investigate the clinicopathological characteristics and prognostic factors of early-stage breast cancer patients with indications for breast cancer susceptibility genes 1/2 (BRCA1/2) genetic testing in China. METHODS: Based on the indication criteria for BRCA genetic testing specified in the National Comprehensive Cancer Network (NCCN) clinical practice guidelines in oncology, genetic/familial high-risk assessment: Breast and ovarian (Version 2. 2019), a retrospective analysis was performed on patients with early-stage invasive breast cancer treated at Breast Disease Center, Peking University First Hospital between January 2008 and December 2016. Clinicopathological characteristics of all patients were analyzed, and prognoses were calculated using the Kaplan-Meier method and a Cox proportionate hazards model. RESULTS: A total of 906 early-stage breast cancer patients who had indications for BRCA genetic testing and had complete clinicopathological data and follow-up information were included in the study group, accounting for 34.7% of all breast cancer patients treated in Breast Disease Center, Peking University First Hospital during the study period. Compared with breast cancer patients without indications for BRCA genetic testing, the overall survival (OS) and disease-free survival (DFS) of patients with indications were not significantly different. In the study group, patients with premenopausal status, high T stage, lymph node positive, estrogen receptor (ER) negative, Ki-67>20% and presence of a vascular tumor thrombus had worse prognosis. There were more family histories of gastrointestinal cancer in patients with related indications than in patients without such indications. CONCLUSIONS: Single-center data showed that more than 30% of patients with early-stage breast cancer had indications for BRCA genetic testing. There was no prognostic difference in patients with or without indications for BRCA genetic testing. Premenopausal status, high T stage, lymph node positive, ER negative, Ki-67>20%, and presence of a vascular tumor thrombus were associated with poor prognosis.
Authors: Juan Zhang; Jie Sun; Jiuan Chen; Lu Yao; Tao Ouyang; Jinfeng Li; Tianfeng Wang; Zhaoqing Fan; Tie Fan; Benyao Lin; Yuntao Xie Journal: Breast Cancer Res Treat Date: 2016-07-08 Impact factor: 4.872
Authors: Timothy R Rebbeck; Nandita Mitra; Fei Wan; Olga M Sinilnikova; Sue Healey; Lesley McGuffog; Sylvie Mazoyer; Georgia Chenevix-Trench; Douglas F Easton; Antonis C Antoniou; Katherine L Nathanson; Yael Laitman; Anya Kushnir; Shani Paluch-Shimon; Raanan Berger; Jamal Zidan; Eitan Friedman; Hans Ehrencrona; Marie Stenmark-Askmalm; Zakaria Einbeigi; Niklas Loman; Katja Harbst; Johanna Rantala; Beatrice Melin; Dezheng Huo; Olufunmilayo I Olopade; Joyce Seldon; Patricia A Ganz; Robert L Nussbaum; Salina B Chan; Kunle Odunsi; Simon A Gayther; Susan M Domchek; Banu K Arun; Karen H Lu; Gillian Mitchell; Beth Y Karlan; Christine Walsh; Jenny Lester; Andrew K Godwin; Harsh Pathak; Eric Ross; Mary B Daly; Alice S Whittemore; Esther M John; Alexander Miron; Mary Beth Terry; Wendy K Chung; David E Goldgar; Saundra S Buys; Ramunas Janavicius; Laima Tihomirova; Nadine Tung; Cecilia M Dorfling; Elizabeth J van Rensburg; Linda Steele; Susan L Neuhausen; Yuan Chun Ding; Bent Ejlertsen; Anne-Marie Gerdes; Thomas v O Hansen; Teresa Ramón y Cajal; Ana Osorio; Javier Benitez; Javier Godino; Maria-Isabel Tejada; Mercedes Duran; Jeffrey N Weitzel; Kristie A Bobolis; Sharon R Sand; Annette Fontaine; Antonella Savarese; Barbara Pasini; Bernard Peissel; Bernardo Bonanni; Daniela Zaffaroni; Francesca Vignolo-Lutati; Giulietta Scuvera; Giuseppe Giannini; Loris Bernard; Maurizio Genuardi; Paolo Radice; Riccardo Dolcetti; Siranoush Manoukian; Valeria Pensotti; Viviana Gismondi; Drakoulis Yannoukakos; Florentia Fostira; Judy Garber; Diana Torres; Muhammad Usman Rashid; Ute Hamann; Susan Peock; Debra Frost; Radka Platte; D Gareth Evans; Rosalind Eeles; Rosemarie Davidson; Diana Eccles; Trevor Cole; Jackie Cook; Carole Brewer; Shirley Hodgson; Patrick J Morrison; Lisa Walker; Mary E Porteous; M John Kennedy; Louise Izatt; Julian Adlard; Alan Donaldson; Steve Ellis; Priyanka Sharma; Rita Katharina Schmutzler; Barbara Wappenschmidt; Alexandra Becker; Kerstin Rhiem; Eric Hahnen; Christoph Engel; Alfons Meindl; Stefanie Engert; Nina Ditsch; Norbert Arnold; Hans Jörg Plendl; Christoph Mundhenke; Dieter Niederacher; Markus Fleisch; Christian Sutter; C R Bartram; Nicola Dikow; Shan Wang-Gohrke; Dorothea Gadzicki; Doris Steinemann; Karin Kast; Marit Beer; Raymonda Varon-Mateeva; Andrea Gehrig; Bernhard H Weber; Dominique Stoppa-Lyonnet; Olga M Sinilnikova; Sylvie Mazoyer; Claude Houdayer; Muriel Belotti; Marion Gauthier-Villars; Francesca Damiola; Nadia Boutry-Kryza; Christine Lasset; Hagay Sobol; Jean-Philippe Peyrat; Danièle Muller; Jean-Pierre Fricker; Marie-Agnès Collonge-Rame; Isabelle Mortemousque; Catherine Nogues; Etienne Rouleau; Claudine Isaacs; Anne De Paepe; Bruce Poppe; Kathleen Claes; Kim De Leeneer; Marion Piedmonte; Gustavo Rodriguez; Katie Wakely; John Boggess; Stephanie V Blank; Jack Basil; Masoud Azodi; Kelly-Anne Phillips; Trinidad Caldes; Miguel de la Hoya; Atocha Romero; Heli Nevanlinna; Kristiina Aittomäki; Annemarie H van der Hout; Frans B L Hogervorst; Senno Verhoef; J Margriet Collée; Caroline Seynaeve; Jan C Oosterwijk; Johannes J P Gille; Juul T Wijnen; Encarna B Gómez Garcia; Carolien M Kets; Margreet G E M Ausems; Cora M Aalfs; Peter Devilee; Arjen R Mensenkamp; Ava Kwong; Edith Olah; Janos Papp; Orland Diez; Conxi Lazaro; Esther Darder; Ignacio Blanco; Mónica Salinas; Anna Jakubowska; Jan Lubinski; Jacek Gronwald; Katarzyna Jaworska-Bieniek; Katarzyna Durda; Grzegorz Sukiennicki; Tomasz Huzarski; Tomasz Byrski; Cezary Cybulski; Aleksandra Toloczko-Grabarek; Elżbieta Złowocka-Perłowska; Janusz Menkiszak; Adalgeir Arason; Rosa B Barkardottir; Jacques Simard; Rachel Laframboise; Marco Montagna; Simona Agata; Elisa Alducci; Ana Peixoto; Manuel R Teixeira; Amanda B Spurdle; Min Hyuk Lee; Sue K Park; Sung-Won Kim; Tara M Friebel; Fergus J Couch; Noralane M Lindor; Vernon S Pankratz; Lucia Guidugli; Xianshu Wang; Marc Tischkowitz; Lenka Foretova; Joseph Vijai; Kenneth Offit; Mark Robson; Rohini Rau-Murthy; Noah Kauff; Anneliese Fink-Retter; Christian F Singer; Christine Rappaport; Daphne Gschwantler-Kaulich; Georg Pfeiler; Muy-Kheng Tea; Andreas Berger; Mark H Greene; Phuong L Mai; Evgeny N Imyanitov; Amanda Ewart Toland; Leigha Senter; Anders Bojesen; Inge Sokilde Pedersen; Anne-Bine Skytte; Lone Sunde; Mads Thomassen; Sanne Traasdahl Moeller; Torben A Kruse; Uffe Birk Jensen; Maria Adelaide Caligo; Paolo Aretini; Soo-Hwang Teo; Christina G Selkirk; Peter J Hulick; Irene Andrulis Journal: JAMA Date: 2015-04-07 Impact factor: 56.272
Authors: Karoline B Kuchenbaecker; John L Hopper; Daniel R Barnes; Kelly-Anne Phillips; Thea M Mooij; Marie-José Roos-Blom; Sarah Jervis; Flora E van Leeuwen; Roger L Milne; Nadine Andrieu; David E Goldgar; Mary Beth Terry; Matti A Rookus; Douglas F Easton; Antonis C Antoniou; Lesley McGuffog; D Gareth Evans; Daniel Barrowdale; Debra Frost; Julian Adlard; Kai-Ren Ong; Louise Izatt; Marc Tischkowitz; Ros Eeles; Rosemarie Davidson; Shirley Hodgson; Steve Ellis; Catherine Nogues; Christine Lasset; Dominique Stoppa-Lyonnet; Jean-Pierre Fricker; Laurence Faivre; Pascaline Berthet; Maartje J Hooning; Lizet E van der Kolk; Carolien M Kets; Muriel A Adank; Esther M John; Wendy K Chung; Irene L Andrulis; Melissa Southey; Mary B Daly; Saundra S Buys; Ana Osorio; Christoph Engel; Karin Kast; Rita K Schmutzler; Trinidad Caldes; Anna Jakubowska; Jacques Simard; Michael L Friedlander; Sue-Anne McLachlan; Eva Machackova; Lenka Foretova; Yen Y Tan; Christian F Singer; Edith Olah; Anne-Marie Gerdes; Brita Arver; Håkan Olsson Journal: JAMA Date: 2017-06-20 Impact factor: 56.272