Carlotta Zacà1, Giovanni Coticchio2, Nicoletta Tarozzi1, Marco Nadalini1, Cristina Lagalla1, Andrea Garolla3, Andrea Borini1. 1. 9.baby - Family and Fertility Center, via Dante 15, 40125, Bologna, Italy. 2. 9.baby - Family and Fertility Center, via Dante 15, 40125, Bologna, Italy. giovanni.coticchio@nove.baby. 3. Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy.
Abstract
PURPOSE: To explore the possible influence of sperm quality, as assessed by prewash total sperm count (TSC), on cumulative success rates in assisted reproduction cycles. METHODS: Retrospective study carried out in private IVF centre. Seven hundred sixty-five couples undergoing complete ICSI cycles, i.e. whose all embryos were transferred or disposed of. Couples were characterised by male infertility and female age younger than 36 years. Couples with a combination of female and male infertility factors were excluded. The primary outcome measure was cumulative live birth rate. Secondary outcomes were cumulative pregnancy and miscarriage rates. No specific interventions were made. RESULTS: Higher TSC values have a positive impact on cumulative success rates in cycles characterised by few retrieved oocytes (1 to 5), while does not influence the outcome of cycles with a normal (6 to 10) or high (> 10) number of retrieved oocytes. CONCLUSIONS: The study highlights the importance of sperm quality for the efficacy of assisted reproduction treatments. This influence may remain relatively cryptic in association with normal or high ovarian response, but emerge decisively in cases of reduced ovarian response, suggesting a relationship between ovarian response and oocyte ability to compensate for paternal-derived deficiencies.
PURPOSE: To explore the possible influence of sperm quality, as assessed by prewash total sperm count (TSC), on cumulative success rates in assisted reproduction cycles. METHODS: Retrospective study carried out in private IVF centre. Seven hundred sixty-five couples undergoing complete ICSI cycles, i.e. whose all embryos were transferred or disposed of. Couples were characterised by male infertility and female age younger than 36 years. Couples with a combination of female and male infertility factors were excluded. The primary outcome measure was cumulative live birth rate. Secondary outcomes were cumulative pregnancy and miscarriage rates. No specific interventions were made. RESULTS: Higher TSC values have a positive impact on cumulative success rates in cycles characterised by few retrieved oocytes (1 to 5), while does not influence the outcome of cycles with a normal (6 to 10) or high (> 10) number of retrieved oocytes. CONCLUSIONS: The study highlights the importance of sperm quality for the efficacy of assisted reproduction treatments. This influence may remain relatively cryptic in association with normal or high ovarian response, but emerge decisively in cases of reduced ovarian response, suggesting a relationship between ovarian response and oocyte ability to compensate for paternal-derived deficiencies.
Entities:
Keywords:
Assisted reproduction; Live birth; Ovarian stimulation; Pregnancy; Sperm count
Authors: M Barragán; J Pons; A Ferrer-Vaquer; D Cornet-Bartolomé; A Schweitzer; J Hubbard; H Auer; A Rodolosse; R Vassena Journal: Mol Hum Reprod Date: 2017-08-01 Impact factor: 4.025
Authors: Ana Cobo; José Bellver; Javier Domingo; Sonia Pérez; Juana Crespo; Antonio Pellicer; José Remohí Journal: Reprod Biomed Online Date: 2008-07 Impact factor: 3.828