Literature DB >> 32403147

GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity.

Nektarios Barabutis1, Mohammad S Akhter1, Mohammad A Uddin1, Khadeja-Tul Kubra1, Andrew V Schally2.   

Abstract

Growth hormone releasing hormone is a hypothalamic neuropeptide, which regulates the release of growth hormone from the anterior pituitary gland. Growth hormone releasing hormone antagonists are anticancer agents, associated with strong anti-inflammatory activities. In the present study, we investigated the effects of the GHRH antagonist MIA-602 in the integrity of the brain microvascular endothelium in vitro. Our observations suggest that MIA-602 protects against the H2O2-induced breakdown of the brain endothelium and enhances its integrity by inducing P53, deactivating cofilin, and suppressing the RhoA inflammatory pathway. Thus, GHRH antagonists may offer an exciting possibility for the treatment of pathologies related to the blood brain barrier dysfunction, including the Parkinson's and Alzheimer's diseases. © Georg Thieme Verlag KG Stuttgart · New York.

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Year:  2020        PMID： 32403147     DOI： 10.1055/a-1149-9347

Source DB:  PubMed          Journal:  Horm Metab Res        ISSN： 0018-5043            Impact factor:   2.936


  10 in total

1.  Unfolded protein response in endothelial injury.

Authors:  Nektarios Barabutis
Journal:  Cell Cycle       Date:  2022-05-26       Impact factor: 5.173

2.  Protective effects of GHRH antagonists against hydrogen peroxide-induced lung endothelial barrier disruption.

Authors:  Mohammad S Akhter; Khadeja-Tul Kubra; Nektarios Barabutis
Journal:  Endocrine       Date:  2022-10-20       Impact factor: 3.925

3.  P53 deficiency potentiates LPS-Induced acute lung injury in vivo.

Authors:  Mohammad A Uddin; Mohammad S Akhter; Khadeja-Tul Kubra; Nektarios Barabutis
Journal:  Curr Res Physiol       Date:  2020-07-09

4.  Involvement of the unfolded protein response in the protective effects of growth hormone releasing hormone antagonists in the lungs.

Authors:  Mohammad S Akhter; Mohammad A Uddin; Andrew V Schally; Khadeja-Tul Kubra; Nektarios Barabutis
Journal:  J Cell Commun Signal       Date:  2020-11-13       Impact factor: 5.782

5.  Protective effects of growth hormone-releasing hormone analogs in DSS-induced colitis in mice.

Authors:  Lucia Recinella; Annalisa Chiavaroli; Valentina Di Valerio; Serena Veschi; Giustino Orlando; Claudio Ferrante; Iacopo Gesmundo; Riccarda Granata; Renzhi Cai; Wei Sha; Andrew V Schally; Rossano Lattanzio; Luigi Brunetti; Sheila Leone
Journal:  Sci Rep       Date:  2021-01-28       Impact factor: 4.379

6.  Induction of the NEK family of kinases in the lungs of mice subjected to cecal ligation and puncture model of sepsis.

Authors:  Mohammad A Uddin; Mohammad S Akhter; Khadeja-Tul Kubra; Nektarios Barabutis
Journal:  Tissue Barriers       Date:  2021-06-20

7.  Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone-releasing hormone.

Authors:  Mohammad S Akhter; Nektarios Barabutis
Journal:  J Biochem Mol Toxicol       Date:  2021-08-08       Impact factor: 3.568

Review 8.  P53 in the impaired lungs.

Authors:  Mohammad A Uddin; Nektarios Barabutis
Journal:  DNA Repair (Amst)       Date:  2020-08-19

9.  Hsp90 inhibition protects the brain microvascular endothelium against oxidative stress.

Authors:  Mohammad A Uddin; Mohammad S Akhter; Khadeja-Tul Kubra; Kathryn E Whitaker; Summer L Shipley; Landon M Smith; Nektarios Barabutis
Journal:  Brain Disord       Date:  2021-01-11

10.  Insights on supporting the aging brain microvascular endothelium.

Authors:  Nektarios Barabutis
Journal:  Aging Brain       Date:  2021-02-22
  10 in total

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