Strategies to Increase the Participation Rate of Colorectal Cancer Screening.

Colorectal cancer (CRC) is one of the most common malignancies and remains the leading cause of cancer-related mortality worldwide.1,2 To reduce the incidence and mortality of CRC, it is important to increase the participation rate of the CRC screening program.3 Fecal immunochemical test (FIT) is currently regarded as the best available noninvasive CRC screening tool. The U.S. Multi-Society Task Force on CRC recommends FIT as the first-tier screening method for CRC, along with colonoscopy.4 The U.S. Multi-Society Task Force on CRC recommends FIT completion rate to those offered testing of 60% or greater.5 Several countries, including South Korea, have adopted FIT in nationwide population-based CRC screening programs. In the Korean National Cancer Screening Program (NCSP), the participation rate has been reported to be lower for CRC screening than other cancers, such as stomach, breast, and cervix cancer; the participation rate was 26%–33% from 2009 to 2012.6

In this issue of Gut and Liver, Hong et al.7 conducted a community-based intervention study to evaluate the impact of the round-mailed FIT kit on the CRC screening rate in underserved regions, and to identify factors related to nonparticipation. Residents were recruited from three rural regions (Jangsu, Goseong, and Uiryeong) lacking NCSP screening units, between 2015 and 2016. A package containing a FIT kit and a return envelope addressed to the local health center was distributed to each subject by mail. Thirty days after postage of the FIT kit, nonresponders were reminded via telephone as the second intervention. They reported that CRC screening participation rates increased from 24.5% to 42.6% as a result of postal screening and increased further to 51.4% after the telephone reminder.7 The intervention of delivering FIT kits to residents of rural areas, followed by phone call reminders for nonresponders, resulted in an increase of about 2.1-fold in the CRC screening participation rate. They also showed that factors associated with nonparticipation were low education level and poor previous participation in the NCSP.7

Although this study is the first intervention study to assess the effectiveness of the round-mailed FIT kit in Korea, many studies on this topic have already been conducted in other countries. It is an expected result, of course, but previous studies have also shown that mailed outreach is superior to usual care alone for CRC screening based on fecal tests.8,9 Recently, a meta-analysis study of seven randomized controlled trials including 12,501 subject (n=5,703 assigned mailed outreach and n=6,798 usual care) in the United States suggests that mailed outreach offering a guaiac fecal occult blood test (gFOBT) or FIT is a highly effective, evidence-based strategy for increasing CRC screening, including among underserved populations.8 More specifically, this meta-analysis study demonstrated that mailed outreach resulted in a 28% absolute and a 2.8-fold relative increase in screening completion compared to usual care.8 Similarly, another comprehensive systematic review of randomized trials and observational studies revealed that multicomponent interventions such as mailing FIT/FOBT materials directly to patient’s homes, use of pre-addressed stamped envelopes to facilitate kit return, and client reminder and recall were highly effective strategies for improving gFOBT/FIT completion rate in rural and low-income populations in the United States.9

Similar to the study by Hong et al., a previous study evaluated the effectiveness of interventions to increase CRC screening in Korea.10 This Korean study compared the participation rates in CRC screening among four groups: control, postal intervention, telephone intervention, and telephone and postal intervention.10 This study showed that subjects who received telephone and postal intervention were most likely (27.8%) to participate in CRC screening, followed by subjects who received telephone intervention only (24.3%), postal intervention only (16.5%), and subjects in the control group (13.5%).10 Combined telephone and postal intervention and telephone only intervention resulted in increased rates of participation in CRC screening compared to the control group, while there was no significant difference between the postal intervention only and control groups. These results suggest that postal intervention alone may not be sufficient to increase the rate of CRC screening.

Given these results, it may be more effective to perform both mail and phone calls simultaneously as the first intervention rather than phone call reminders for nonresponders as the second intervention. In other words, the optimal strategy to increase FIT completion rate may be by telephone to instruct the screenees to collect stool using the FIT kit and return the stool sample using the enclosed envelope. These instructions would be most effective if provided when sending the FIT kit. These aggressive interventions will be especially necessary for persons who are less likely to participate in CRC screening, such as persons with low education level, those who have poorly participated in previous screening, or rural residents.