Literature DB >> 32399930

Design of a Peptide-Carrier Vaccine Based on the Highly Immunogenic Fasciola hepatica Leucine Aminopeptidase.

Cecilia Salazar1,2, José F Tort3, Carlos Carmona4.   

Abstract

Many studies have shown that the degree of organization and repetitiveness of an antigen correlates with its efficiency to induce a B-cell response and production of neutralizing antibodies. Here we describe the design of a chimeric protein based on the hexamer form of the highly immunogenic Fasciola hepatica leucine aminopeptidase as a carrier system of small peptides with potential use as a multiepitope vaccine.

Entities:  

Keywords:  Fasciola hepatica juvenile; Multiepitope vaccine; Oligomer-peptide carrier system

Mesh：

Substances：

Year:  2020        PMID： 32399930     DOI： 10.1007/978-1-0716-0475-5_14

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  43 in total

1.  The recombinant gut-associated M17 leucine aminopeptidase in combination with different adjuvants confers a high level of protection against Fasciola hepatica infection in sheep.

Authors:  Gabriela Maggioli; Daniel Acosta; Fernando Silveira; Silvina Rossi; Sheila Giacaman; Tatiana Basika; Valeria Gayo; Diego Rosadilla; Leda Roche; José Tort; Carlos Carmona
Journal:  Vaccine       Date:  2011-09-20       Impact factor: 3.641

Review 2.  Recent advances in the molecular design of synthetic vaccines.

Authors:  Lyn H Jones
Journal:  Nat Chem       Date:  2015-12       Impact factor: 24.427

3.  Brucella spp. lumazine synthase: a novel adjuvant and antigen delivery system to effectively induce oral immunity.

Authors:  Gabriela Rosas; Gladis Fragoso; Natalia Ainciart; Fernando Esquivel-Guadarrama; Angélica Santana; Raúl J Bobes; Oscar Ramírez-Pliego; Andrea Toledo; Carmen Cruz-Revilla; Gabriela Meneses; Paula Berguer; Fernando A Goldbaum; Edda Sciutto
Journal:  Microbes Infect       Date:  2006-02-07       Impact factor: 2.700

Review 4.  Pattern recognition by B cells: the role of antigen repetitiveness versus Toll-like receptors.

Authors:  H J Hinton; A Jegerlehner; M F Bachmann
Journal:  Curr Top Microbiol Immunol       Date:  2008       Impact factor: 4.291

5.  Engineering of a polymeric bacterial protein as a scaffold for the multiple display of peptides.

Authors:  D A Laplagne; V Zylberman; N Ainciart; M W Steward; E Sciutto; C A Fossati; F A Goldbaum
Journal:  Proteins       Date:  2004-12-01

6.  Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance.

Authors:  J B Sun; J Holmgren; C Czerkinsky
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-08       Impact factor: 11.205

7.  Fasciola hepatica leucine aminopeptidase, a promising candidate for vaccination against ruminant fasciolosis.

Authors:  Daniel Acosta; Martín Cancela; Lucia Piacenza; Leda Roche; Carlos Carmona; José F Tort
Journal:  Mol Biochem Parasitol       Date:  2007-11-22       Impact factor: 1.759

8.  Mucosal immunization with a genetically engineered pertussis toxin S1 fragment-cholera toxin subunit B chimeric protein.

Authors:  Song F Lee; Scott A Halperin; Danny F Salloum; Ann MacMillan; Annette Morris
Journal:  Infect Immun       Date:  2003-04       Impact factor: 3.441

9.  Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.

Authors:  M P Cooke; A W Heath; K M Shokat; Y Zeng; F D Finkelman; P S Linsley; M Howard; C C Goodnow
Journal:  J Exp Med       Date:  1994-02-01       Impact factor: 14.307

Review 10.  Epitope mapping: the first step in developing epitope-based vaccines.

Authors:  Jonathan M Gershoni; Anna Roitburd-Berman; Dror D Siman-Tov; Natalia Tarnovitski Freund; Yael Weiss
Journal:  BioDrugs       Date:  2007       Impact factor: 5.807
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