Daniel S Kashi1,2, Samuel J Oliver3, Laurel M Wentz4, Ross Roberts1, Alexander T Carswell1, Jonathan C Y Tang5, Sarah Jackson6, Rachel M Izard7, Donald Allan8, Lesley E Rhodes9, William D Fraser5, Julie P Greeves5,6, Neil P Walsh2. 1. College of Human Sciences, Bangor University, Bangor, LL57 2PZ, UK. 2. Faculty of Science, Liverpool John Moores University, Liverpool, UK. 3. College of Human Sciences, Bangor University, Bangor, LL57 2PZ, UK. s.j.oliver@bangor.ac.uk. 4. Beaver College of Health Sciences, Appalachian State University, Boone, USA. 5. Norwich Medical School, University of East Anglia, Norwich, UK. 6. Department of Army Health and Physical Performance Research, Army HQ, Andover, UK. 7. Occupational Medicine, HQ Army Recruiting and Initial Training Command, Upavon, UK. 8. Medical Physics Department, Salford Royal NHS Foundation Trust, and University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. 9. Faculty of Biology, Medicine and Health, University of Manchester, and Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Abstract
PURPOSE: To determine serum 25(OH)D and 1,25(OH)2D relationship with hepatitis B vaccination (study 1). Then, to investigate the effects on hepatitis B vaccination of achieving vitamin D sufficiency (serum 25(OH)D ≥ 50 nmol/L) by a unique comparison of simulated sunlight and oral vitamin D3 supplementation in wintertime (study 2). METHODS: Study 1 involved 447 adults. In study 2, 3 days after the initial hepatitis B vaccination, 119 men received either placebo, simulated sunlight (1.3 × standard-erythema dose, 3 × /week for 4 weeks and then 1 × /week for 8 weeks) or oral vitamin D3 (1000 IU/day for 4 weeks and 400 IU/day for 8 weeks). We measured hepatitis B vaccination efficacy as percentage of responders with anti-hepatitis B surface antigen immunoglobulin G ≥ 10 mIU/mL. RESULTS: In study 1, vaccine response was poorer in persons with low vitamin D status (25(OH)D ≤ 40 vs 41-71 nmol/L mean difference [95% confidence interval] - 15% [- 26, - 3%]; 1,25(OH)2D ≤ 120 vs ≥ 157 pmol/L - 12% [- 24%, - 1%]). Vaccine response was also poorer in winter than summer (- 18% [- 31%, - 3%]), when serum 25(OH)D and 1,25(OH)2D were at seasonal nadirs, and 81% of persons had serum 25(OH)D < 50 nmol/L. In study 2, vitamin D supplementation strategies were similarly effective in achieving vitamin D sufficiency from the winter vitamin D nadir in almost all (~ 95%); however, the supplementation beginning 3 days after the initial vaccination did not effect the vaccine response (vitamin D vs placebo 4% [- 21%, 14%]). CONCLUSION: Low vitamin D status at initial vaccination was associated with poorer hepatitis B vaccine response (study 1); however, vitamin D supplementation commencing 3 days after vaccination (study 2) did not influence the vaccination response. CLINICAL TRIAL REGISTRY NUMBER: Study 1 NCT02416895; https://clinicaltrials.gov/ct2/show/study/NCT02416895 ; Study 2 NCT03132103; https://clinicaltrials.gov/ct2/show/NCT03132103 .
PURPOSE: To determine serum 25(OH)D and 1,25(OH)2D relationship with hepatitis B vaccination (study 1). Then, to investigate the effects on hepatitis B vaccination of achieving vitamin D sufficiency (serum 25(OH)D ≥ 50 nmol/L) by a unique comparison of simulated sunlight and oral vitamin D3 supplementation in wintertime (study 2). METHODS: Study 1 involved 447 adults. In study 2, 3 days after the initial hepatitis B vaccination, 119 men received either placebo, simulated sunlight (1.3 × standard-erythema dose, 3 × /week for 4 weeks and then 1 × /week for 8 weeks) or oral vitamin D3 (1000 IU/day for 4 weeks and 400 IU/day for 8 weeks). We measured hepatitis B vaccination efficacy as percentage of responders with anti-hepatitis B surface antigen immunoglobulin G ≥ 10 mIU/mL. RESULTS: In study 1, vaccine response was poorer in persons with low vitamin D status (25(OH)D ≤ 40 vs 41-71 nmol/L mean difference [95% confidence interval] - 15% [- 26, - 3%]; 1,25(OH)2D ≤ 120 vs ≥ 157 pmol/L - 12% [- 24%, - 1%]). Vaccine response was also poorer in winter than summer (- 18% [- 31%, - 3%]), when serum 25(OH)D and 1,25(OH)2D were at seasonal nadirs, and 81% of persons had serum 25(OH)D < 50 nmol/L. In study 2, vitamin D supplementation strategies were similarly effective in achieving vitamin D sufficiency from the winter vitamin D nadir in almost all (~ 95%); however, the supplementation beginning 3 days after the initial vaccination did not effect the vaccine response (vitamin D vs placebo 4% [- 21%, 14%]). CONCLUSION: Low vitamin D status at initial vaccination was associated with poorer hepatitis B vaccine response (study 1); however, vitamin D supplementation commencing 3 days after vaccination (study 2) did not influence the vaccination response. CLINICAL TRIAL REGISTRY NUMBER: Study 1 NCT02416895; https://clinicaltrials.gov/ct2/show/study/NCT02416895 ; Study 2 NCT03132103; https://clinicaltrials.gov/ct2/show/NCT03132103 .
Entities:
Keywords:
25-Hydroxyvitamin D; Cholecalciferol; Hepatitis B; UVB; Vaccination; Vitamin D
Authors: Aric A Prather; Martica Hall; Jacqueline M Fury; Diana C Ross; Matthew F Muldoon; Sheldon Cohen; Anna L Marsland Journal: Sleep Date: 2012-08-01 Impact factor: 5.849
Authors: Adam D Harper Smith; Sarah L Coakley; Mark D Ward; Andrew W Macfarlane; Peter S Friedmann; Neil P Walsh Journal: Brain Behav Immun Date: 2011-03-06 Impact factor: 7.217
Authors: Tian-Tian Wang; Frederick P Nestel; Véronique Bourdeau; Yoshihiko Nagai; Qiuyu Wang; Jie Liao; Luz Tavera-Mendoza; Roberto Lin; John W Hanrahan; Sylvie Mader; John H White; John H Hanrahan Journal: J Immunol Date: 2004-09-01 Impact factor: 5.422
Authors: Daniel E Roth; Steven A Abrams; John Aloia; Gilles Bergeron; Megan W Bourassa; Kenneth H Brown; Mona S Calvo; Kevin D Cashman; Gerald Combs; Luz María De-Regil; Maria Elena Jefferds; Kerry S Jones; Hallie Kapner; Adrian R Martineau; Lynnette M Neufeld; Rosemary L Schleicher; Tom D Thacher; Susan J Whiting Journal: Ann N Y Acad Sci Date: 2018-09-18 Impact factor: 5.691
Authors: Sarah Schillie; Claudia Vellozzi; Arthur Reingold; Aaron Harris; Penina Haber; John W Ward; Noele P Nelson Journal: MMWR Recomm Rep Date: 2018-01-12
Authors: Sophie E Harrison; Samuel J Oliver; Daniel S Kashi; Alexander T Carswell; Jason P Edwards; Laurel M Wentz; Ross Roberts; Jonathan C Y Tang; Rachel M Izard; Sarah Jackson; Donald Allan; Lesley E Rhodes; William D Fraser; Julie P Greeves; Neil P Walsh Journal: Med Sci Sports Exerc Date: 2021-07-01
Authors: R E Neale; P W Barnes; T M Robson; P J Neale; C E Williamson; R G Zepp; S R Wilson; S Madronich; A L Andrady; A M Heikkilä; G H Bernhard; A F Bais; P J Aucamp; A T Banaszak; J F Bornman; L S Bruckman; S N Byrne; B Foereid; D-P Häder; L M Hollestein; W-C Hou; S Hylander; M A K Jansen; A R Klekociuk; J B Liley; J Longstreth; R M Lucas; J Martinez-Abaigar; K McNeill; C M Olsen; K K Pandey; L E Rhodes; S A Robinson; K C Rose; T Schikowski; K R Solomon; B Sulzberger; J E Ukpebor; Q-W Wang; S-Å Wängberg; C C White; S Yazar; A R Young; P J Young; L Zhu; M Zhu Journal: Photochem Photobiol Sci Date: 2021-01-20 Impact factor: 4.328
Authors: Javier S Morales; Pedro L Valenzuela; Adrián Castillo-García; Javier Butragueño; David Jiménez-Pavón; Pedro Carrera-Bastos; Alejandro Lucia Journal: Nutrients Date: 2021-12-22 Impact factor: 5.717
Authors: Yifei Ma; Pengfei Zhu; Guanqing Zhong; Dao Wang; Lu Cao; Shenrui Bai; Youlong Wang; Ao Zhang; Xinjia Wang Journal: Front Med (Lausanne) Date: 2022-07-29
Authors: Diego Fernández-Lázaro; Manuel Garrosa; Nerea Sánchez-Serrano; Evelina Garrosa; Elena Jiménez-Callejo; María Dolores Pardo Yanguas; Juan Mielgo-Ayuso; Jesús Seco-Calvo Journal: Vaccines (Basel) Date: 2022-07-22
Authors: Annika Fendler; Elisabeth G E de Vries; Corine H GeurtsvanKessel; John B Haanen; Bernhard Wörmann; Samra Turajlic; Marie von Lilienfeld-Toal Journal: Nat Rev Clin Oncol Date: 2022-03-11 Impact factor: 65.011