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Literature DB >> 32386554

High-Fidelity Modeling of Human Microglia with Pluripotent Stem Cells.

Abstract

Gosselin et al. (2017) reported that a tissue-environment-dependent transcriptional network specifies human microglia identity and that in vitro environments drastically alter the human microglia transcriptome. Recent 3-dimensional culture and human-mouse chimeric brain modeling systems developed using human pluripotent stem cells help us understand the complex properties of human microglia.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Year: 2020 PMID： 32386554 PMCID： PMC7262396 DOI： 10.1016/j.stem.2020.04.004

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

10 in total

1. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.

Authors: Edsel M Abud; Ricardo N Ramirez; Eric S Martinez; Luke M Healy; Cecilia H H Nguyen; Sean A Newman; Andriy V Yeromin; Vanessa M Scarfone; Samuel E Marsh; Cristhian Fimbres; Chad A Caraway; Gianna M Fote; Abdullah M Madany; Anshu Agrawal; Rakez Kayed; Karen H Gylys; Michael D Cahalan; Brian J Cummings; Jack P Antel; Ali Mortazavi; Monica J Carson; Wayne W Poon; Mathew Blurton-Jones
Journal: Neuron Date: 2017-04-19 Impact factor: 17.173

2. Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain.

Authors: Devon S Svoboda; M Inmaculada Barrasa; Jian Shu; Rosalie Rietjens; Shupei Zhang; Maya Mitalipova; Peter Berube; Dongdong Fu; Leonard D Shultz; George W Bell; Rudolf Jaenisch
Journal: Proc Natl Acad Sci U S A Date: 2019-11-26 Impact factor: 11.205

3. Stem-cell-derived human microglia transplanted in mouse brain to study human disease.

Authors: Renzo Mancuso; Johanna Van Den Daele; Nicola Fattorelli; Leen Wolfs; Sriram Balusu; Oliver Burton; Adrian Liston; Annerieke Sierksma; Yannick Fourne; Suresh Poovathingal; Amaia Arranz-Mendiguren; Carlo Sala Frigerio; Christel Claes; Lutgarde Serneels; Tom Theys; V Hugh Perry; Catherine Verfaillie; Mark Fiers; Bart De Strooper
Journal: Nat Neurosci Date: 2019-10-28 Impact factor: 24.884

4. An environment-dependent transcriptional network specifies human microglia identity.

Authors: David Gosselin; Dylan Skola; Nicole G Coufal; Inge R Holtman; Johannes C M Schlachetzki; Eniko Sajti; Baptiste N Jaeger; Carolyn O'Connor; Conor Fitzpatrick; Martina P Pasillas; Monique Pena; Amy Adair; David D Gonda; Michael L Levy; Richard M Ransohoff; Fred H Gage; Christopher K Glass
Journal: Science Date: 2017-05-25 Impact factor: 47.728

5. Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.

Authors: Jonathan Hasselmann; Morgan A Coburn; Whitney England; Dario X Figueroa Velez; Sepideh Kiani Shabestari; Christina H Tu; Amanda McQuade; Mahshad Kolahdouzan; Karla Echeverria; Christel Claes; Taylor Nakayama; Ricardo Azevedo; Nicole G Coufal; Claudia Z Han; Brian J Cummings; Hayk Davtyan; Christopher K Glass; Luke M Healy; Sunil P Gandhi; Robert C Spitale; Mathew Blurton-Jones
Journal: Neuron Date: 2019-07-30 Impact factor: 17.173

6. Transcriptomic analysis of purified human cortical microglia reveals age-associated changes.

Authors: Thais F Galatro; Inge R Holtman; Antonio M Lerario; Ilia D Vainchtein; Nieske Brouwer; Paula R Sola; Mariana M Veras; Tulio F Pereira; Renata E P Leite; Thomas Möller; Paul D Wes; Mari C Sogayar; Jon D Laman; Wilfred den Dunnen; Carlos A Pasqualucci; Sueli M Oba-Shinjo; Erik W G M Boddeke; Suely K N Marie; Bart J L Eggen
Journal: Nat Neurosci Date: 2017-07-03 Impact factor: 24.884

7. Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains.

Authors: Weizhe Li; Santhi Gorantla; Howard E Gendelman; Larisa Y Poluektova
Journal: Dis Model Mech Date: 2017-12-19 Impact factor: 5.758

8. Efficient derivation of microglia-like cells from human pluripotent stem cells.

Authors: Julien Muffat; Yun Li; Bingbing Yuan; Maisam Mitalipova; Attya Omer; Sean Corcoran; Grisilda Bakiasi; Li-Huei Tsai; Patrick Aubourg; Richard M Ransohoff; Rudolf Jaenisch
Journal: Nat Med Date: 2016-09-26 Impact factor: 53.440

9. Microglia innately develop within cerebral organoids.

Authors: Paul R Ormel; Renata Vieira de Sá; Emma J van Bodegraven; Henk Karst; Oliver Harschnitz; Marjolein A M Sneeboer; Lill Eva Johansen; Roland E van Dijk; Nicky Scheefhals; Amber Berdenis van Berlekom; Eduardo Ribes Martínez; Sandra Kling; Harold D MacGillavry; Leonard H van den Berg; René S Kahn; Elly M Hol; Lot D de Witte; R Jeroen Pasterkamp
Journal: Nat Commun Date: 2018-10-09 Impact factor: 14.919

10. Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain.

Authors: Ranjie Xu; Xiaoxi Li; Andrew J Boreland; Anthony Posyton; Kelvin Kwan; Ronald P Hart; Peng Jiang
Journal: Nat Commun Date: 2020-03-27 Impact factor: 14.919

10 in total

3 in total

1. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.

Authors: Mengmeng Jin; Ranjie Xu; Le Wang; Mahabub Maraj Alam; Ziyuan Ma; Sining Zhu; Alessandra C Martini; Azadeh Jadali; Matteo Bernabucci; Ping Xie; Kelvin Y Kwan; Zhiping P Pang; Elizabeth Head; Ying Liu; Ronald P Hart; Peng Jiang
Journal: Cell Stem Cell Date: 2022-07-07 Impact factor: 25.269

2. Rise of the human-mouse chimeric brain models.

Authors: Peng Jiang; Mahabub Maraj Alam
Journal: Cell Regen Date: 2022-09-03

3. Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology.

Authors: Ranjie Xu; Andrew J Boreland; Xiaoxi Li; Caroline Erickson; Mengmeng Jin; Colm Atkins; Zhiping P Pang; Brian P Daniels; Peng Jiang
Journal: Stem Cell Reports Date: 2021-07-22 Impact factor: 7.765

3 in total