| Literature DB >> 31659342 |
Renzo Mancuso1,2, Johanna Van Den Daele3,4, Nicola Fattorelli5,3, Leen Wolfs5,3, Sriram Balusu5,3, Oliver Burton5,3, Adrian Liston5,3, Annerieke Sierksma5,3, Yannick Fourne5,3, Suresh Poovathingal5,3, Amaia Arranz-Mendiguren5,3, Carlo Sala Frigerio5,3, Christel Claes3,4, Lutgarde Serneels5,3, Tom Theys6, V Hugh Perry7, Catherine Verfaillie4, Mark Fiers5,3, Bart De Strooper8,9,10.
Abstract
Although genetics highlights the role of microglia in Alzheimer's disease, one-third of putative Alzheimer's disease risk genes lack adequate mouse orthologs. Here we successfully engraft human microglia derived from embryonic stem cells in the mouse brain. The cells recapitulate transcriptionally human primary microglia ex vivo and show expression of human-specific Alzheimer's disease risk genes. Oligomeric amyloid-β induces a divergent response in human versus mouse microglia. This model can be used to study the role of microglia in neurological diseases.Entities:
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Year: 2019 PMID： 31659342 DOI： 10.1038/s41593-019-0525-x
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884