Kijeong Lee1, Ji Sung Lee2, Jinkwon Kim3, Huisong Lee4, Yoonkyung Chang5, Ho Geol Woo6, Jin-Woo Kim7, Tae-Jin Song6. 1. Department of Neurology, Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. 2. Clinical Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 3. Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. 4. Department of Surgery, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea. 5. Department of Neurology, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea. 6. Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea. 7. Department of Oral and Maxillofacial Surgery, College of Medicine, Ewha Womans University, Seoul, Korea.
Abstract
AIMS: Poor oral hygiene is closely associated with bacteraemia and systemic inflammation, which are known mediators of cancer development. We investigated the relationship between oral hygiene indicators and the risk of gastrointestinal cancer in a nationwide population-based cohort. MATERIALS AND METHODS: This study was conducted on data from 150,774 subjects from the Korean National Health Screening Cohort. The occurrence of gastrointestinal cancer was analysed according to the presence of periodontal disease and oral hygiene indicators: frequency of toothbrushing, dental visits for any reason, professional dental cleanings and number of missing teeth. Gastrointestinal cancer was defined using International Statistical Classification of Diseases-10 codes C15-C26. RESULTS: During a median 11.6 years of follow-up, the estimated 10-year event rate for gastrointestinal cancer was 6.76%. In a multivariable analysis, after adjusting for age, sex, income level, regular exercise, alcohol consumption, smoking status, body mass index, history of comorbidities, systolic blood pressure and laboratory findings, frequent toothbrushing (≥3/day) was significantly associated with a reduced risk for gastrointestinal cancer (hazard ratio: 0.91, 95% confidence interval (0.86-0.96), p < .001, p for trend < .001). CONCLUSIONS: Good oral hygiene behaviour, especially frequent toothbrushing, could be associated with a lower risk of gastrointestinal cancer.
AIMS: Poor oral hygiene is closely associated with bacteraemia and systemic inflammation, which are known mediators of cancer development. We investigated the relationship between oral hygiene indicators and the risk of gastrointestinal cancer in a nationwide population-based cohort. MATERIALS AND METHODS: This study was conducted on data from 150,774 subjects from the Korean National Health Screening Cohort. The occurrence of gastrointestinal cancer was analysed according to the presence of periodontal disease and oral hygiene indicators: frequency of toothbrushing, dental visits for any reason, professional dental cleanings and number of missing teeth. Gastrointestinal cancer was defined using International Statistical Classification of Diseases-10 codes C15-C26. RESULTS: During a median 11.6 years of follow-up, the estimated 10-year event rate for gastrointestinal cancer was 6.76%. In a multivariable analysis, after adjusting for age, sex, income level, regular exercise, alcohol consumption, smoking status, body mass index, history of comorbidities, systolic blood pressure and laboratory findings, frequent toothbrushing (≥3/day) was significantly associated with a reduced risk for gastrointestinal cancer (hazard ratio: 0.91, 95% confidence interval (0.86-0.96), p < .001, p for trend < .001). CONCLUSIONS: Good oral hygiene behaviour, especially frequent toothbrushing, could be associated with a lower risk of gastrointestinal cancer.
Authors: Flavia Mirela Nicolae; Francesco Bennardo; Selene Barone; Petra Șurlin; Dorin Nicolae Gheorghe; Daniela Burtea; Ștefan Pătrascu; Sandu Râmboiu; Adrian Petru Radu; Bogdan Silviu Ungureanu; Adina Turcu-Știolica; Andreea Cristiana Didilescu; Victor Dan Eugen Strâmbu; Valeriu Marin Șurlin; Dan Ionuț Gheonea Journal: J Pers Med Date: 2022-04-26