| Literature DB >> 32376769 |
Byron Brook1, Danny J Harbeson1, Casey P Shannon2,3, Bing Cai4, Daniel He1,2,3, Rym Ben-Othman4, Freddy Francis1, Joe Huang4, Natallia Varankovich4, Aaron Liu1, Winnie Bao4, Morten Bjerregaard-Andersen5,6,7, Frederik Schaltz-Buchholzer5,6,8, Lilica Sanca5, Christian N Golding5,6, Kristina Lindberg Larsen5,6, Ofer Levy9,10,11, Beate Kampmann12,13, Rusung Tan14, Adrian Charles14, James L Wynn15, Frank Shann16, Peter Aaby5, Christine S Benn5,6,8, Scott J Tebbutt2,3,17, Tobias R Kollmann18,4,19, Nelly Amenyogbe18,19.
Abstract
Death from sepsis in the neonatal period remains a serious threat for millions. Within 3 days of administration, bacille Calmette-Guérin (BCG) vaccination can reduce mortality from neonatal sepsis in human newborns, but the underlying mechanism for this rapid protection is unknown. We found that BCG was also protective in a mouse model of neonatal polymicrobial sepsis, where it induced granulocyte colony-stimulating factor (G-CSF) within hours of administration. This was necessary and sufficient to drive emergency granulopoiesis (EG), resulting in a marked increase in neutrophils. This increase in neutrophils was directly and quantitatively responsible for protection from sepsis. Rapid induction of EG after BCG administration also occurred in three independent cohorts of human neonates.Entities:
Year: 2020 PMID： 32376769 PMCID： PMC8008103 DOI： 10.1126/scitranslmed.aax4517
Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956