Literature DB >> 32372227

Soluble CD146-an underreported novel biomarker of congestion: a comment on a review concerning congestion assessment and evaluation in acute heart failure.

Justas Simonavičius1,2,3, Aurimas Mikalauskas4, Hans-Peter Brunner-La Rocca5.   

Abstract

In spite of high prevalence, congestion remains a poorly understood phenomenon in heart failure pathophysiology. Its negative impact on outcome has been widely recognised. Still, data from various registries reveal the failure of the contemporary treatment strategies to overcome congestion. This shortcoming is closely related to the fact that there are no universe means for congestion assessment and grading, making it a difficult process to recognise. CD146 is a novel blood biomarker of congestion that has been shown to reflect intravascular fluid accumulation in a number of experimental and clinical studies. This observation deserves special attention, given the huge gap of knowledge about decongestive strategies in acute and chronic heart failure. Randomised clinical trials testing the effect of CD146-guided management intervention are urgently needed to estimate its value in heart failure care.

Entities:  

Keywords:  CD146; Congestion; Fluid accumulation; Heart failure; Loop diuretic; Overhydration

Mesh：

Substances：

Year:  2021        PMID： 32372227     DOI： 10.1007/s10741-020-09950-y

Source DB:  PubMed          Journal:  Heart Fail Rev        ISSN： 1382-4147            Impact factor:   4.214


  6 in total

1.  Soluble CD146 and B-type natriuretic peptide dissect overhydration into functional components of prognostic relevance in haemodialysis patients.

Authors:  Mattia Arrigo; Seraina Von Moos; Kerem Gerritsen; Malha Sadoune; Kamonwan Tangvoraphonkchai; Andrew Davenport; Alexandre Mebazaa; Stephan Segerer; Pietro E Cippà
Journal:  Nephrol Dial Transplant       Date:  2018-11-01       Impact factor: 5.992

Review 2.  Loop diuretics in chronic heart failure: how to manage congestion?

Authors:  Justas Simonavičius; Christian Knackstedt; Hans-Peter Brunner-La Rocca
Journal:  Heart Fail Rev       Date:  2019-01       Impact factor: 4.214

3.  Soluble CD146 Is a Novel Marker of Systemic Congestion in Heart Failure Patients: An Experimental Mechanistic and Transcardiac Clinical Study.

Authors:  Mattia Arrigo; Quynh A Truong; Duygu Onat; Jackie Szymonifka; Etienne Gayat; Heli Tolppanen; Malha Sadoune; Ryan T Demmer; Ka Y Wong; Jean Marie Launay; Jane-Lise Samuel; Alain Cohen-Solal; James L Januzzi; Jagmeet P Singh; Paolo C Colombo; Alexandre Mebazaa
Journal:  Clin Chem       Date:  2016-10-25       Impact factor: 8.327

4.  Soluble CD146, a new endothelial biomarker of acutely decompensated heart failure.

Authors:  Etienne Gayat; Anaïs Caillard; Saïd Laribi; Christian Mueller; Malha Sadoune; Marie-France Seronde; Alan Maisel; Jozef Bartunek; Marc Vanderheyden; Johan Desutter; Paul Dendale; Gregoire Thomas; Miguel Tavares; Alain Cohen-Solal; Jane-Lise Samuel; Alexandre Mebazaa
Journal:  Int J Cardiol       Date:  2015-07-12       Impact factor: 4.164

Review 5.  Congestion occurrence and evaluation in acute heart failure scenario: time to reconsider different pathways of volume overload.

Authors:  Alberto Palazzuoli; Isabella Evangelista; Ranuccio Nuti
Journal:  Heart Fail Rev       Date:  2020-01       Impact factor: 4.214

6.  Plasma Levels of Soluble CD146 Reflect the Severity of Pulmonary Congestion Better Than Brain Natriuretic Peptide in Acute Coronary Syndrome.

Authors:  Petr Kubena; Mattia Arrigo; Jiri Parenica; Etienne Gayat; Malha Sadoune; Eva Ganovska; Marie Pavlusova; Simona Littnerova; Jindrich Spinar; Alexandre Mebazaa
Journal:  Ann Lab Med       Date:  2016-07       Impact factor: 3.464
  6 in total
  1 in total

1.  Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway.

Authors:  Zhao-Yu Zhang; Chao Zhai; Xue-Yuan Yang; Hai-Bing Li; Li-Ling Wu; Li Li
Journal:  PLoS One       Date:  2022-08-24       Impact factor: 3.752
  1 in total

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