Mattia Arrigo1,2,3,4, Quynh A Truong5,6, Duygu Onat7, Jackie Szymonifka5,6, Etienne Gayat1,2, Heli Tolppanen1, Malha Sadoune1, Ryan T Demmer7, Ka Y Wong7, Jean Marie Launay8, Jane-Lise Samuel1, Alain Cohen-Solal1,3, James L Januzzi6, Jagmeet P Singh6, Paolo C Colombo7, Alexandre Mebazaa9,2. 1. INSERM UMR-S 942, Paris, France. 2. Université Paris Diderot, PRES Sorbonne Paris Cité, France; Department of Anesthesiology and Critical Care Medicine, AP-HP, Saint Louis Lariboisière University Hospitals, Paris, France. 3. Université Paris Diderot, PRES Sorbonne Paris Cité, France, Department of Cardiology, AP-HP, Saint Louis Lariboisière University Hospitals, Paris, France. 4. Department of Cardiology, University Heart Center, University Hospital Zurich, Switzerland. 5. Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY. 6. Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 7. Division of Cardiology, Columbia University Medical Center, New York NY. 8. Université Paris Diderot, PRES Sorbonne Paris Cité, France, Department of Biochemistry, AP-HP, Lariboisière University Hospitals, Paris, France. 9. INSERM UMR-S 942, Paris, France; alexandre.mebazaa@aphp.fr.
Abstract
BACKGROUND: Soluble CD146 (sCD146), is an endothelial marker with similar diagnostic power as natriuretic peptides in decompensated heart failure (HF). While natriuretic peptides are released by the failing heart, sCD146 may be released by veins in response to stretch induced by systemic congestion in HF. This study investigated the source, effects of vascular stress on release and prognostic properties of sCD146 in HF. METHODS: In a peripheral venous stress study, plasma concentrations of sCD146 and N-terminal probrain natriuretic-peptide (NT-proBNP) were measured in 44 HF patients at baseline and after 90 min of unilateral forearm venous congestion. In addition, sCD146 and NT-proBNP were measured in peripheral vein (PV) and coronary sinus (CS) blood samples of 137 HF patients and the transcardiac gradient was calculated. Those patients were followed for major adverse cardiovascular events (MACE) during 2 years. RESULTS: The induction of venous stress was associated with a pronounced increase in circulating concentrations of sCD146 in the congested arm (+60 μg/L) compared to the control arm (+16 μg/L, P = 0.025), while no difference in NT-proBNP concentrations was seen. In contrast to positive transcardiac gradient for NT-proBNP, median sCD146 concentrations were lower in CS than in PV (396 vs 434, P < 0.001), indicating a predominantly extracardiac source of sCD146. Finally, increased PV concentrations of sCD146 were associated with higher risk of MACE at 2 years. CONCLUSIONS: Soluble CD146 is released from the peripheral vasculature in response to venous stretch and may reflect systemic congestion in chronic HF patients.
BACKGROUND: Soluble CD146 (sCD146), is an endothelial marker with similar diagnostic power as natriuretic peptides in decompensated heart failure (HF). While natriuretic peptides are released by the failing heart, sCD146 may be released by veins in response to stretch induced by systemic congestion in HF. This study investigated the source, effects of vascular stress on release and prognostic properties of sCD146 in HF. METHODS: In a peripheral venous stress study, plasma concentrations of sCD146 and N-terminal probrain natriuretic-peptide (NT-proBNP) were measured in 44 HF patients at baseline and after 90 min of unilateral forearm venous congestion. In addition, sCD146 and NT-proBNP were measured in peripheral vein (PV) and coronary sinus (CS) blood samples of 137 HF patients and the transcardiac gradient was calculated. Those patients were followed for major adverse cardiovascular events (MACE) during 2 years. RESULTS: The induction of venous stress was associated with a pronounced increase in circulating concentrations of sCD146 in the congested arm (+60 μg/L) compared to the control arm (+16 μg/L, P = 0.025), while no difference in NT-proBNP concentrations was seen. In contrast to positive transcardiac gradient for NT-proBNP, median sCD146 concentrations were lower in CS than in PV (396 vs 434, P < 0.001), indicating a predominantly extracardiac source of sCD146. Finally, increased PV concentrations of sCD146 were associated with higher risk of MACE at 2 years. CONCLUSIONS: Soluble CD146 is released from the peripheral vasculature in response to venous stretch and may reflect systemic congestion in chronic HF patients.
Authors: Eva M Boorsma; Jozine M Ter Maaten; Kevin Damman; Wilfried Dinh; Finn Gustafsson; Steven Goldsmith; Daniel Burkhoff; Faiez Zannad; James E Udelson; Adriaan A Voors Journal: Nat Rev Cardiol Date: 2020-05-15 Impact factor: 32.419
Authors: Mattia Arrigo; Nicolas Vodovar; Hélène Nougué; Malha Sadoune; Chris J Pemberton; Pamela Ballan; Pierre-Olivier Ludes; Nicolas Gendron; Alain Carpentier; Bernard Cholley; Philippe Bizouarn; Alain Cohen-Solal; Jagmeet P Singh; Jackie Szymonifka; Christian Latremouille; Jane-Lise Samuel; Jean-Marie Launay; Julien Pottecher; A Mark Richards; Quynh A Truong; David M Smadja; Alexandre Mebazaa Journal: Eur Heart J Date: 2018-05-21 Impact factor: 29.983