BACKGROUND: A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged and caused the rapid spread of coronavirus disease 2019 (COVID-19) worldwide. METHODS: We did a retrospective study and included COVID-19 patients admitted to Renmin Hospital of Wuhan University between 1 February and 29 February 2020. Antibody assay was conducted to detect COVID-19 envelope protein E and nucleocapsid protein N antigen. RESULTS: One hundred twelve patients were recruited with symptoms of fever, cough, fatigue, myalgia, and diarrhea. All patients underwent antibody tests. Fifty-eight (51.79%) were positive for both immunoglobulin M (IgM) and immunoglobulin G (IgG), 7 (6.25%) were negative for both antibodies, 1 (0.89%) was positive for only IgM, and 46 (41.07%) were positive for only IgG. IgM antibody appeared within a week post-disease onset, lasted for 1 month, and gradually decreased, whereas IgG antibody was produced 10 days after infection and lasted for a longer time. However, no significant difference in levels of IgM and IgG antibodies between positive and negative patients of nucleic acid test after treatment was found. CONCLUSIONS: Our results indicate that serological tests could be a powerful approach for the early diagnosis of COVID-19.
BACKGROUND: A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently emerged and caused the rapid spread of coronavirus disease 2019 (COVID-19) worldwide. METHODS: We did a retrospective study and included COVID-19patients admitted to Renmin Hospital of Wuhan University between 1 February and 29 February 2020. Antibody assay was conducted to detect COVID-19 envelope protein E and nucleocapsid protein N antigen. RESULTS: One hundred twelve patients were recruited with symptoms of fever, cough, fatigue, myalgia, and diarrhea. All patients underwent antibody tests. Fifty-eight (51.79%) were positive for both immunoglobulin M (IgM) and immunoglobulin G (IgG), 7 (6.25%) were negative for both antibodies, 1 (0.89%) was positive for only IgM, and 46 (41.07%) were positive for only IgG. IgM antibody appeared within a week post-disease onset, lasted for 1 month, and gradually decreased, whereas IgG antibody was produced 10 days after infection and lasted for a longer time. However, no significant difference in levels of IgM and IgG antibodies between positive and negative patients of nucleic acid test after treatment was found. CONCLUSIONS: Our results indicate that serological tests could be a powerful approach for the early diagnosis of COVID-19.
Authors: Tawanda Chivese; Joshua T Matizanadzo; Omran A H Musa; George Hindy; Luis Furuya-Kanamori; Nazmul Islam; Rafal Al-Shebly; Rana Shalaby; Mohammad Habibullah; Talal A Al-Marwani; Rizeq F Hourani; Ahmed D Nawaz; Mohammad Z Haider; Mohamed M Emara; Farhan Cyprian; Suhail A R Doi Journal: Pathog Glob Health Date: 2022-01-31 Impact factor: 3.735
Authors: Andrew Cameron; Claire A Porterfield; Larry D Byron; Jiong Wang; Zachary Pearson; Jessica L Bohrhunter; Anthony B Cardillo; Lindsay Ryan-Muntz; Ryan A Sorensen; Mary T Caserta; Stephen Angeloni; Dwight J Hardy; Martin S Zand; Nicole D Pecora Journal: J Clin Microbiol Date: 2021-01-21 Impact factor: 5.948
Authors: Samuel Pecho-Silva; Ana Claudia Navarro-Solsol; Vicky Panduro-Correa; Ali A Rabaan; Jorge L Maguiña; Alfonso J Rodriguez-Morales; Kovy Arteaga-Livias Journal: Chemotherapy Date: 2021-05-07 Impact factor: 2.544