BACKGROUND AND OBJECTIVES: The purpose of this study was to assess efficacy and safety of a new patterned theta burst stimulation algorithm of DBS with the aim of expanding the therapeutic window and clinical benefit in PD. METHODS: In this single-center, randomized, double-blind, clinical short-term trial, unilateral conventional subthalamic DBS was compared with unilateral patterned stimulation algorithms with intraburst high- or low-frequency theta burst stimulation in 17 PD patients. RESULTS: There were no serious adverse events with theta burst stimulation. During monopolar review, conventional subthalamic DBS and high-frequency theta burst stimulation were comparable, but low-frequency theta burst stimulation differed by requiring higher stimulation amplitudes for symptom reduction, but a larger therapeutic window. High- and low-frequency theta burst stimulation with adapted stimulation amplitude were effective in PD symptom reduction with differential effects on akinesia and tremor, depending on the theta burst stimulation mode. CONCLUSIONS: Theta burst stimulation is a safe and effective stimulation mode with potential future application opportunities.
RCT Entities:
BACKGROUND AND OBJECTIVES: The purpose of this study was to assess efficacy and safety of a new patterned theta burst stimulation algorithm of DBS with the aim of expanding the therapeutic window and clinical benefit in PD. METHODS: In this single-center, randomized, double-blind, clinical short-term trial, unilateral conventional subthalamic DBS was compared with unilateral patterned stimulation algorithms with intraburst high- or low-frequency theta burst stimulation in 17 PDpatients. RESULTS: There were no serious adverse events with theta burst stimulation. During monopolar review, conventional subthalamic DBS and high-frequency theta burst stimulation were comparable, but low-frequency theta burst stimulation differed by requiring higher stimulation amplitudes for symptom reduction, but a larger therapeutic window. High- and low-frequency theta burst stimulation with adapted stimulation amplitude were effective in PD symptom reduction with differential effects on akinesia and tremor, depending on the theta burst stimulation mode. CONCLUSIONS: Theta burst stimulation is a safe and effective stimulation mode with potential future application opportunities.
Authors: Jose L Herrero; Alexander Smith; Akash Mishra; Noah Markowitz; Ashesh D Mehta; Stephan Bickel Journal: J Neurophysiol Date: 2021-10-13 Impact factor: 2.714
Authors: Jessica Frey; Jackson Cagle; Kara A Johnson; Joshua K Wong; Justin D Hilliard; Christopher R Butson; Michael S Okun; Coralie de Hemptinne Journal: Front Neurol Date: 2022-03-09 Impact factor: 4.003
Authors: Michael S Okun; Patrick T Hickey; Andre G Machado; Alexis M Kuncel; Warren M Grill Journal: Front Hum Neurosci Date: 2022-08-24 Impact factor: 3.473
Authors: Michel Sáenz-Farret; Aaron Loh; Alexandre Boutet; Jürgen Germann; Gavin J B Elias; Suneil K Kalia; Robert Chen; Andres M Lozano; Alfonso Fasano Journal: Mov Disord Clin Pract Date: 2021-01-11