Takaaki Fujii1, Shoko Tokuda2, Yuko Nakazawa2, Sasagu Kurozumi2, Sayaka Obayashi2, Reina Yajima2, Ken Shirabe2. 1. Division of Breast and Endocrine Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan ftakaaki@gunma-u.ac.jp. 2. Division of Breast and Endocrine Surgery, Department of General Surgical Science, Graduate School of Medicine, Gunma University, Gunma, Japan.
Abstract
BACKGROUND/AIM: We investigated the relationship between F18-fluorodeoxyglucose (FDG) uptake and the platelet/lymphocyte ratio (PLR), as both represent inflammation. PATIENTS AND METHODS: We retrospectively analyzed the cases of 143 consecutive invasive ductal carcinoma patients who had undergone preoperative FDG-PET and surgery. We divided the patients into groups based on their maximum standardized uptake value (SUVmax) values: low (<2.5) and high (≥2.5) and based on their PLRs: low (<130) and high (≥130). We determined the relationships between the SUVmax or PLR and clinicopathological features. RESULTS: Seventy-three patients (51.0%) had a high SUVmax in their primary tumor. There were significant associations between SUVmax and the PLR. A multivariate analysis revealed that high PLR, but not NLR, was independent factor associated with a high SUVmax. Seventy-four patients (51.7%) had a high PLR; The factors significantly associated with high PLR were large tumor size, presence of node metastasis, presence of vascular invasion, high NLR, and high SUVmax. CONCLUSION: In breast cancer patients, the PLR is independently associated with the SUVmax, but not with recurrent disease. In breast cancer patients with a high SUVmax and/or PLR, these values may reflect the tumor microenvironment. Copyright
BACKGROUND/AIM: We investigated the relationship between F18-fluorodeoxyglucose (FDG) uptake and the platelet/lymphocyte ratio (PLR), as both represent inflammation. PATIENTS AND METHODS: We retrospectively analyzed the cases of 143 consecutive invasive ductal carcinomapatients who had undergone preoperative FDG-PET and surgery. We divided the patients into groups based on their maximum standardized uptake value (SUVmax) values: low (<2.5) and high (≥2.5) and based on their PLRs: low (<130) and high (≥130). We determined the relationships between the SUVmax or PLR and clinicopathological features. RESULTS: Seventy-three patients (51.0%) had a high SUVmax in their primary tumor. There were significant associations between SUVmax and the PLR. A multivariate analysis revealed that high PLR, but not NLR, was independent factor associated with a high SUVmax. Seventy-four patients (51.7%) had a high PLR; The factors significantly associated with high PLR were large tumor size, presence of node metastasis, presence of vascular invasion, high NLR, and high SUVmax. CONCLUSION: In breast cancerpatients, the PLR is independently associated with the SUVmax, but not with recurrent disease. In breast cancerpatients with a high SUVmax and/or PLR, these values may reflect the tumor microenvironment. Copyright
Authors: Seyda Gündüz; Sema Sezgin Göksu; Deniz Arslan; Ali Murat Tatli; Mükremin Uysal; Umut Riza Gündüz; Mert Mahsuni Sevinç; Hasan Senol Coşkun; Hakan Bozcuk; Hasan Mutlu; Burhan Savas Journal: Mol Clin Oncol Date: 2015-07-21
Authors: James W Fletcher; Benjamin Djulbegovic; Heloisa P Soares; Barry A Siegel; Val J Lowe; Gary H Lyman; R Edward Coleman; Richard Wahl; John Christopher Paschold; Norbert Avril; Lawrence H Einhorn; W Warren Suh; David Samson; Dominique Delbeke; Mark Gorman; Anthony F Shields Journal: J Nucl Med Date: 2008-02-20 Impact factor: 10.057
Authors: Ashley M Groves; Manu Shastry; Simona Ben-Haim; Irfan Kayani; Anmol Malhotra; Timothy Davidson; Tina Kelleher; Diane Whittaker; Marie Meagher; Brian Holloway; Ruth M Warren; Peter J Ell; Mohammed R Keshtgar Journal: Oncologist Date: 2012-04-26