Gianluca Vanni1, Marco Materazzo2, Marco Pellicciaro1, Ljuba Morando1, Ilaria Portarena3, Lucia Anemona4, Maria Rolando D'Angelillo5, Rosaria Barbarino5, Agostino Chiaravalloti6,7, Rosaria Meucci1,8, Tommaso Perretta8, Camilla Deiana1, Paolo Orsaria9, Jonathan Caspi1, Chiara Adriana Pistolese8, Oreste Claudio Buonomo1. 1. Breast Unit - Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy. 2. Breast Unit - Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy mrcmaterazzo@gmail.com. 3. Department of Oncology, Policlinico Tor Vergata University, Rome, Italy. 4. Anatomic Pathology, Department of Experimental Medicine, Policlinico Tor Vergata University, Rome, Italy. 5. Radiotherapy Unit, Department of Oncology and Hematology, Policlinico Tor Vergata University, Rome, Italy. 6. Department of Biomedicine and Prevention, Policlinico Tor Vergata University, Rome, Italy. 7. IRCCS Neuromed, UOC Medicina Nucleare, Pozzilli, Italy. 8. Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, Policlinico Tor Vergata University, Rome, Italy. 9. Department of Breast Surgery, University Campus Bio-Medico, Rome, Italy.
Abstract
BACKGROUND/AIM: In 2016, in the United States, more than 50% of breast cancer (BC) cases were diagnosed in patients older than 60 years of age. Our study aimed to estimate the risk of locoregional recurrence (LR) in patients who underwent breast-conservative treatment (BCT), according to age. PATIENTS AND METHODS: This retrospective monocentric study analyzed 613 cases of patients who underwent BCT between 2003 and 2014. Patients were divided into groups according to age: Under70 (under 70 years old) and Over70 (above 70 years old). Margins width, histology results, prognostic and predictive factors were compared. Subgroup analysis was performed for patients who experienced LR. RESULTS: LR Incidence among Under70 and Over70 was 5.4% and 1.7%, respectively (p<0.01). Group Over70 is characterized by larger tumors and a lower Ki67 index (p<0.01). CONCLUSION: Operation time reduction, better aesthetic results and reduced LR risk support BCT. The Over70 group exhibited better outcomes in terms of LR despite larger tumor dimensions. Copyright
BACKGROUND/AIM: In 2016, in the United States, more than 50% of breast cancer (BC) cases were diagnosed in patients older than 60 years of age. Our study aimed to estimate the risk of locoregional recurrence (LR) in patients who underwent breast-conservative treatment (BCT), according to age. PATIENTS AND METHODS: This retrospective monocentric study analyzed 613 cases of patients who underwent BCT between 2003 and 2014. Patients were divided into groups according to age: Under70 (under 70 years old) and Over70 (above 70 years old). Margins width, histology results, prognostic and predictive factors were compared. Subgroup analysis was performed for patients who experienced LR. RESULTS: LR Incidence among Under70 and Over70 was 5.4% and 1.7%, respectively (p<0.01). Group Over70 is characterized by larger tumors and a lower Ki67 index (p<0.01). CONCLUSION: Operation time reduction, better aesthetic results and reduced LR risk support BCT. The Over70 group exhibited better outcomes in terms of LR despite larger tumor dimensions. Copyright
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