Tamar Monteiro1, Magdalena Wysocka2, Elena Tellez3, Ofelia Monteiro3, Luzia Spencer3, Elisa Veiga3, Sandra Monteiro4, Carine de Pina1, Deisy Gonçalves1, Sandrine de Pina1, Antonio Ludgero-Correia1, Joao Moreno1, Teresa Conceição5, Marta Aires-de-Sousa5, Herminia de Lencastre6, Laura J Gray7, Manish Pareek8, David R Jenkins9, Sandra Beleza10, Marco R Oggioni11, Isabel Inês Araujo1. 1. Faculdade de Ciências e Tecnologia, Universidade de Cabo Verde, Praia, Santiago, Cabo Verde. 2. Department of Genetics and Genome Biology, University of Leicester, Leicester, UK; Department of Molecular Biotechnology and Microbiology, Gdansk University of Technology, Gdansk, Poland. 3. Hospital Agostinho Neto, Ministério da Saúde e Segurança Social, Praia, Santiago, Cabo Verde. 4. Hospital Baptista de Sousa, Ministério da Saúde e Segurança Social, Mindelo, São Vicente, Cabo Verde. 5. Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica António Xavier (ITQB-NOVA), Universidade Nova de Lisboa, Oeiras, Portugal. 6. Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica António Xavier (ITQB-NOVA), Universidade Nova de Lisboa, Oeiras, Portugal; Laboratory of Microbiology & Infectious Diseases, The Rockefeller University, New York, USA. 7. Department of Health Sciences, University of Leicester, Leicester, UK. 8. Department of Respiratory Sciences, University of Leicester, Leicester, UK. 9. Department of Clinical Microbiology, University Hospitals of Leicester, NHS Trust, Leicester, UK. 10. Department of Genetics and Genome Biology, University of Leicester, Leicester, UK. 11. Department of Genetics and Genome Biology, University of Leicester, Leicester, UK. Electronic address: mro5@leicester.ac.uk.
Abstract
OBJECTIVES: Data on baseline drug resistance important in informing future antimicrobial stewardship programs. So far, no data on the antimicrobial drug resistance of clinical isolates available for the African archipelago of Cabo Verde. METHODS: We performed a retrospective analysis over years (2013-17) of the drug susceptibility profiles of clinical isolates in the two main hospitals of Cabo Verde. For Escherichia coli and Staphylococcus aureus, representing 47% and 26% of all clinical isolates, the antimicrobial drug resistance profile was reported for six representative drugs. RESULTS: For E. coli we detected an increase in resistance to ampicillin, amoxicillin/clavulanic acid, ceftriaxone, ciprofloxacin and trimethoprim-and for S. aureus to methicillin, erythromycin and trimethoprim-sulfamethoxazole. This increase in both the most commonly isolated bacterial pathogens is alarm as it might compromise empirical treatment in a setting with limited access to laboratory testing. CONCLUSIONS: When compared to the published low resistance rates in carriage isolates, the more alarming situation in clinical isolates for S. aureus might encourage antimicrobial stewardship programs to reduce in hospital settings, possibly as part of the Cabo Verdean national plan against antimicrobial drug resistance.
OBJECTIVES: Data on baseline drug resistance important in informing future antimicrobial stewardship programs. So far, no data on the antimicrobial drug resistance of clinical isolates available for the African archipelago of Cabo Verde. METHODS: We performed a retrospective analysis over years (2013-17) of the drug susceptibility profiles of clinical isolates in the two main hospitals of Cabo Verde. For Escherichia coli and Staphylococcus aureus, representing 47% and 26% of all clinical isolates, the antimicrobial drug resistance profile was reported for six representative drugs. RESULTS: For E. coli we detected an increase in resistance to ampicillin, amoxicillin/clavulanic acid, ceftriaxone, ciprofloxacin and trimethoprim-and for S. aureus to methicillin, erythromycin and trimethoprim-sulfamethoxazole. This increase in both the most commonly isolated bacterial pathogens is alarm as it might compromise empirical treatment in a setting with limited access to laboratory testing. CONCLUSIONS: When compared to the published low resistance rates in carriage isolates, the more alarming situation in clinical isolates for S. aureus might encourage antimicrobial stewardship programs to reduce in hospital settings, possibly as part of the Cabo Verdean national plan against antimicrobial drug resistance.
Authors: Magdalena Wysocka; Tamar Monteiro; Carine de Pina; Deisy Gonçalves; Sandrine de Pina; Antonio Ludgero-Correia; Joao Moreno; Roxana Zamudio; Nada Almebairik; Laura J Gray; Manish Pareek; David R Jenkins; Marta Aires-de-Sousa; Herminia De Lencastre; Sandra Beleza; Isabel I Araujo; Teresa Conceição; Marco R Oggioni Journal: J Glob Antimicrob Resist Date: 2021-05-27 Impact factor: 4.035