Literature DB >> 32346980

Towards restoring proper chromosome segregation and preventing ageing.

Laura Tovini1, Sarah E McClelland1.   

Abstract

The natural progressive dysfunction of most living organisms-ageing-has captured the attention of several studies, with the intention to develop rejuvenation strategies. Evidence is emerging of a positive correlation between natural ageing and chromosomal instability (CIN). In this issue of EMBO Reports, Barroso-Vilares et al [1] now show a link between ageing and the erroneous assembly of the apparatus required for a proper cellular division. They compare this mechanism in young and naturally aged human cells and describe a strategy to delay age-related CIN.
© 2020 The Authors.

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Year:  2020        PMID： 32346980      PMCID： PMC7202055          DOI： 10.15252/embr.202050322

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  10 in total

Review 1.  The role of senescent cells in ageing.

Authors:  Jan M van Deursen
Journal:  Nature       Date:  2014-05-22       Impact factor: 49.962

2.  Mitotic misregulation and human aging.

Authors:  D H Ly; D J Lockhart; R A Lerner; P G Schultz
Journal:  Science       Date:  2000-03-31       Impact factor: 47.728

3.  Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells.

Authors:  Bernardo Orr; Lama Talje; Zhexian Liu; Benjamin H Kwok; Duane A Compton
Journal:  Cell Rep       Date:  2016-11-08       Impact factor: 9.423

4.  Towards restoring proper chromosome segregation and preventing ageing.

Authors:  Laura Tovini; Sarah E McClelland
Journal:  EMBO Rep       Date:  2020-04-28       Impact factor: 8.807

Review 5.  The hallmarks of aging.

Authors:  Carlos López-Otín; Maria A Blasco; Linda Partridge; Manuel Serrano; Guido Kroemer
Journal:  Cell       Date:  2013-06-06       Impact factor: 41.582

6.  Chromosome Segregation Is Biased by Kinetochore Size.

Authors:  Danica Drpic; Ana C Almeida; Paulo Aguiar; Fioranna Renda; Joana Damas; Harris A Lewin; Denis M Larkin; Alexey Khodjakov; Helder Maiato
Journal:  Curr Biol       Date:  2018-04-26       Impact factor: 10.834

7.  Small-molecule inhibition of aging-associated chromosomal instability delays cellular senescence.

Authors:  Monika Barroso-Vilares; Joana C Macedo; Marta Reis; Jessica D Warren; Duane Compton; Elsa Logarinho
Journal:  EMBO Rep       Date:  2020-03-05       Impact factor: 8.807

8.  Genome stability is ensured by temporal control of kinetochore-microtubule dynamics.

Authors:  Samuel F Bakhoum; Sarah L Thompson; Amity L Manning; Duane A Compton
Journal:  Nat Cell Biol       Date:  2008-12-07       Impact factor: 28.824

Review 9.  Turning back time with emerging rejuvenation strategies.

Authors:  Salah Mahmoudi; Lucy Xu; Anne Brunet
Journal:  Nat Cell Biol       Date:  2019-01-02       Impact factor: 28.824

10.  Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.

Authors:  Darren J Baker; Bennett G Childs; Matej Durik; Melinde E Wijers; Cynthia J Sieben; Jian Zhong; Rachel A Saltness; Karthik B Jeganathan; Grace Casaclang Verzosa; Abdulmohammad Pezeshki; Khashayarsha Khazaie; Jordan D Miller; Jan M van Deursen
Journal:  Nature       Date:  2016-02-03       Impact factor: 49.962
  10 in total
  1 in total

1.  Towards restoring proper chromosome segregation and preventing ageing.

Authors:  Laura Tovini; Sarah E McClelland
Journal:  EMBO Rep       Date:  2020-04-28       Impact factor: 8.807
  1 in total

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