Antonella Daniele1, Angelo Virgilio Paradiso2, Rosa Divella2, Maria Digennaro3, Margherita Patruno3, Stefania Tommasi4, Brunella Pilato4, Antonio Tufaro2, Michele Barone5, Carla Minoia6, Donatella Colangelo7, Eufemia Savino7, Porzia Casamassima7, Eleonora Bruno8, Andreina Oliverio8, Patrizia Pasanisi8. 1. Experimental Oncology and Biobank Management Unit - IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy anto.dani27@gmail.com. 2. Experimental Oncology and Biobank Management Unit - IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy. 3. Experimental Oncology - Center for Study of Heredo-Familial Tumors - IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy. 4. Molecular Diagnostics and Pharmacogenetics Unit - IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy. 5. Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy. 6. Onco-Hematology Unit - IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy. 7. Clinical Pathology Laboratory - IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy. 8. Epidemiology and Prevention Unit - Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Abstract
BACKGROUND: Environmental factors may influence the lifetime risk of cancer (penetrance) in women with a BRCA mutation. MATERIALS AND METHODS: In 89 BRCA-mutant women, affected or unaffected by breast/ovarian cancer, we explored serum levels of adipokines and their relation with the polymorphism SNP276G>T as modulators of BRCA penetrance. RESULTS: Affected women had significantly lower adiponectin than healthy women. Affected women with rs1501299 TT had significantly lower adiponectin and higher leptin than GT and GG genotypes. GT genotype was significantly associated with the disease status [odds ratio (OR)=3.24, 95% confidence interval (95% CI)=1.03-10.17]. Women in the lower tertile of serum adiponectin had a RR of BRCA-associated cancer of 2.80, 95% CI=1.1-7.1 (p for trend=0.03) compared with women in the higher tertile. CONCLUSION: In the SNP rs1501299 the T allele was significantly associated with lower serum levels of adiponectin in affected women, suggesting that the T allele might be related to cancer. Copyright
BACKGROUND: Environmental factors may influence the lifetime risk of cancer (penetrance) in women with a BRCA mutation. MATERIALS AND METHODS: In 89 BRCA-mutant women, affected or unaffected by breast/ovarian cancer, we explored serum levels of adipokines and their relation with the polymorphism SNP276G>T as modulators of BRCA penetrance. RESULTS: Affected women had significantly lower adiponectin than healthy women. Affected women with rs1501299 TT had significantly lower adiponectin and higher leptin than GT and GG genotypes. GT genotype was significantly associated with the disease status [odds ratio (OR)=3.24, 95% confidence interval (95% CI)=1.03-10.17]. Women in the lower tertile of serum adiponectin had a RR of BRCA-associated cancer of 2.80, 95% CI=1.1-7.1 (p for trend=0.03) compared with women in the higher tertile. CONCLUSION: In the SNP rs1501299 the T allele was significantly associated with lower serum levels of adiponectin in affected women, suggesting that the T allele might be related to cancer. Copyright
Authors: Damien C Croteau-Chonka; Ying Wu; Yun Li; Marie P Fogarty; Leslie A Lange; Christopher W Kuzawa; Thomas W McDade; Judith B Borja; Jingchun Luo; Omar AbdelBaky; Terry P Combs; Linda S Adair; Ethan M Lange; Karen L Mohlke Journal: Hum Mol Genet Date: 2011-10-18 Impact factor: 6.150
Authors: Harald Staiger; Otto Tschritter; Jürgen Machann; Claus Thamer; Andreas Fritsche; Elke Maerker; Fritz Schick; Hans-Ulrich Häring; Michael Stumvoll Journal: Obes Res Date: 2003-03