Rosa Divella1, Antonella Daniele2, Raffaele DE Luca3, Antonio Mazzocca4, Eustachio Ruggieri3, Eufemia Savino5, Porzia Casamassima5, Michele Simone3, Carlo Sabba4, Angelo Paradiso2. 1. Institutional BioBank, Experimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy rosadive@inwind.it. 2. Institutional BioBank, Experimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy. 3. Department of Surgery Oncology, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy. 4. Interdisciplinary Department of Medicine, University of Bari School of Medicine, Bari, Italy. 5. Clinical Pathology Laboratory, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
Abstract
BACKGROUND/AIM: The aim of this study was to evaluate whether the altered profile of adipocytokine and genetic fingerprint in NAFLD-associated metabolic syndrome "cluster" represents synergistic risk factors predicting onset of liver colorectal cancer metastases. MATERIALS AND METHODS: A total of 165 colorectal cancer patients were enrolled, 56,3% were with metabolic syndrome/NAFLD. Serum samples were assayed for ADIPOQ, leptin and TNF-a levels by ELISA. ADIPOQ rs266729 C/G and TNF-308 A/G genotypes were analyzed in DNA isolated from whole blood. RESULTS: Reduction in adiponectin levels and increase in leptin and TNF-α was shown in patients with liver metastases. This trend was influenced by BMI, MetS/NAFLD, and insulin resistance. ADIPOQ G rs266729 and TNF- 308 A allele are associated with obesity, MetS/NAFLD and insulin resistance. ADIPOQ CG/GG and GA/AA TNF-alpha genotypes confer susceptibility to liver metastases. CONCLUSION: Obesity and hepatic steatosis significantly favor the development of colorectal cancer liver metastases and the individual adipocytokines genetic profile may play an important predictive role. Copyright
BACKGROUND/AIM: The aim of this study was to evaluate whether the altered profile of adipocytokine and genetic fingerprint in NAFLD-associated metabolic syndrome "cluster" represents synergistic risk factors predicting onset of liver colorectal cancer metastases. MATERIALS AND METHODS: A total of 165 colorectal cancerpatients were enrolled, 56,3% were with metabolic syndrome/NAFLD. Serum samples were assayed for ADIPOQ, leptin and TNF-a levels by ELISA. ADIPOQrs266729 C/G and TNF-308 A/G genotypes were analyzed in DNA isolated from whole blood. RESULTS: Reduction in adiponectin levels and increase in leptin and TNF-α was shown in patients with liver metastases. This trend was influenced by BMI, MetS/NAFLD, and insulin resistance. ADIPOQ G rs266729 and TNF- 308 A allele are associated with obesity, MetS/NAFLD and insulin resistance. ADIPOQ CG/GG and GA/AA TNF-alpha genotypes confer susceptibility to liver metastases. CONCLUSION:Obesity and hepatic steatosis significantly favor the development of colorectal cancer liver metastases and the individual adipocytokines genetic profile may play an important predictive role. Copyright
Authors: J S Ahn; D H Sinn; Y W Min; S N Hong; H S Kim; S-H Jung; S Gu; P-L Rhee; S W Paik; H J Son; G-Y Gwak Journal: Aliment Pharmacol Ther Date: 2016-11-18 Impact factor: 8.171
Authors: Haiying Zhou; Yanzhao Dong; Ahmad Alhaskawi; Jingtian Lai; Zewei Wang; Sohaib Hasan Abdullah Ezzi; Vishnu Goutham Kota; Mohamed Hasan Abdulla Hasan Abdulla; Zhenyu Sun; Hui Lu Journal: Front Pharmacol Date: 2022-06-29 Impact factor: 5.988