| Literature DB >> 32333308 |
V K Tishchenko1, V M Petriev2,3, A A Mikhailovskaya1, E D Stepchenkova1, V Yu Timoshenko4,5,6, A A Postnov4, I N Zavestovskaya4,5.
Abstract
We investigate biodistribution of gallium-labeled hydroxyethylidenediphosphonic acid (68Ga-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) (68Ga-DTPMP) in intact Wistar rats. It was shown that 68Ga-DTPMP accumulated mainly in the bone tissue providing high femur/blood and femur/muscle ratios and had high stability in vivo. In contrast, 68Ga-HEDP was characterized by low stability and high uptake of radioactivity in blood throughout the study. So 68Ga-DTPMP can be considered as a new prospective radiotracer in oncology for imaging bone tissue metastasis by positron emission tomography.Entities:
Keywords: gallium-68; oncology; phosphonic acids; positron emission tomography; radionuclides
Year: 2020 PMID： 32333308 DOI： 10.1007/s10517-020-04800-1
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804