A comparative study of the permeation of dihexadecyl phosphate vesicles by various carboxylic acids and some of their tetrazole analogues.

The evaluation of the effect that perturbers may have on a membrane model is described. The model was made from dihexadecyl phosphate bilayers. The perturbers used were carboxylic acids and some of their tetrazole analogues. The results show a good correlation between the permeation properties of the carboxylic acids and tetrazole analogues. Moreover, this study reveals that membrane-perturbing effects are mainly under the control of conformational parameters and dependent on the carbon chain length of the permeants.