Gianluca Milanese1, Mario Silva2, Roberta Eufrasia Ledda3, Matteo Goldoni4, Sundeep Nayak5, Livia Bruno6, Enrica Rossi7, Erica Maffei8, Filippo Cademartiri9, Nicola Sverzellati10. 1. Division of Scienze Radiologiche, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy. Electronic address: gianluca.milanese@unipr.it. 2. Division of Scienze Radiologiche, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy. Electronic address: mario.silva@unipr.it. 3. Division of Scienze Radiologiche, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy. Electronic address: robertaeufrasia.ledda@unipr.it. 4. Department of Medicine and Surgery, University of Parma, Parma, Italy. Electronic address: matteo.goldoni@unipr.it. 5. Department of Radiology, Kaiser Permanente Northern California, San Leandro, CA, USA. 6. Department of Radiology, University of Palermo, Palermo, Italy. 7. Department of Imaging, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. 8. Department of Radiology, Area Vasta 1/ASUR Marche, Urbino, Italy. 9. Advanced Cardiovascular Imaging, SDN IRCCS, via Gianturco 113, Naples, Italy. 10. Division of Scienze Radiologiche, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy. Electronic address: nicola.sverzellati@unipr.it.
Abstract
BACKGROUND: To determine if an increased epicardial fat volume (EFV) is associated with coronary artery disease (CAD) in individuals with symptoms of cardiovascular (CV) disease. METHODS: Coronary Computed Tomographic Angiography (CCTA), demographic and clinical variables of 1344 individuals were retrieved: semi-automated measurements for EFV and coronary artery calcifications (CAC) were obtained. Individuals were grouped into three categories according to the presence of CAD, resulting in absent (CAD0), non-obstructive (CAD1) or obstructive (CAD2) disease-groups. Relation of EFV with CAD was assessed with two approaches: 1) presence of any CAD; 2) each individual CAD category. RESULTS: Median EFV was 90.52 ml (range 11.27-442.21 ml); median CAC was 56.5 (range 0-10,144); 848 individuals (63.1%) were categorized as CAD0, 326 (24.3%) as CAD1, 170 (12.6%) as CAD2. EFV was lower in subjects without CAC (EFVmedian = 66.5 ml), as compared to those with CAC 0.1-100 (EFVmedian = 91.47), CAC 100.1-400 (EFVmedian = 97.46) and CAC >400 (EFVmedian = 109.48) (p < 0.001). EFV was lower in CAD0 (EFVmedian = 87.21 ml), as compared to CAD1 (EFVmedian = 93.89 ml) and CAD2 (EFVmedian = 102.98 ml) individuals (p < 0.001). A logistic regression model built by including demographic and clinical variables showed inconsistent predictive value of EFV for either CAD1 or CAD2 (p > 0.05). CONCLUSIONS: In the setting of symptomatic individuals, an increased amount of epicardial fat was associated with larger amount of coronary artery calcifications and was observed in individuals with obstructive CAD, however without predictive value to confidently determine CAD presence and severity.
BACKGROUND: To determine if an increased epicardial fat volume (EFV) is associated with coronary artery disease (CAD) in individuals with symptoms of cardiovascular (CV) disease. METHODS: Coronary Computed Tomographic Angiography (CCTA), demographic and clinical variables of 1344 individuals were retrieved: semi-automated measurements for EFV and coronary artery calcifications (CAC) were obtained. Individuals were grouped into three categories according to the presence of CAD, resulting in absent (CAD0), non-obstructive (CAD1) or obstructive (CAD2) disease-groups. Relation of EFV with CAD was assessed with two approaches: 1) presence of any CAD; 2) each individual CAD category. RESULTS: Median EFV was 90.52 ml (range 11.27-442.21 ml); median CAC was 56.5 (range 0-10,144); 848 individuals (63.1%) were categorized as CAD0, 326 (24.3%) as CAD1, 170 (12.6%) as CAD2. EFV was lower in subjects without CAC (EFVmedian = 66.5 ml), as compared to those with CAC 0.1-100 (EFVmedian = 91.47), CAC 100.1-400 (EFVmedian = 97.46) and CAC >400 (EFVmedian = 109.48) (p < 0.001). EFV was lower in CAD0 (EFVmedian = 87.21 ml), as compared to CAD1 (EFVmedian = 93.89 ml) and CAD2 (EFVmedian = 102.98 ml) individuals (p < 0.001). A logistic regression model built by including demographic and clinical variables showed inconsistent predictive value of EFV for either CAD1 or CAD2 (p > 0.05). CONCLUSIONS: In the setting of symptomatic individuals, an increased amount of epicardial fat was associated with larger amount of coronary artery calcifications and was observed in individuals with obstructive CAD, however without predictive value to confidently determine CAD presence and severity.
Authors: David Molnar; Olof Enqvist; Johannes Ulén; Måns Larsson; John Brandberg; Åse A Johnsson; Elias Björnson; Göran Bergström; Ola Hjelmgren Journal: Sci Rep Date: 2021-12-13 Impact factor: 4.379
Authors: Anne Ruth van Meijeren; Daan Ties; Marie-Sophie L Y de Koning; Randy van Dijk; Irene V van Blokland; Pablo Lizana Veloz; Gijs van Woerden; Rozemarijn Vliegenthart; Gabija Pundziute; Daan B Westenbrink; Pim van der Harst Journal: Int J Cardiol Heart Vasc Date: 2022-03-29