| Literature DB >> 32327758 |
Waradon Sungnak1, Ni Huang2, Christophe Bécavin3, Marijn Berg4,5, Rachel Queen6, Monika Litvinukova2,7, Carlos Talavera-López2, Henrike Maatz7, Daniel Reichart8, Fotios Sampaziotis9,10,11, Kaylee B Worlock12, Masahiro Yoshida12, Josephine L Barnes12.
Abstract
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.Entities:
Year: 2020 PMID： 32327758 PMCID： PMC8637938 DOI： 10.1038/s41591-020-0868-6
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440