Literature DB >> 32314144

Allicin Alleviates Lead-Induced Bone Loss by Preventing Oxidative Stress and Osteoclastogenesis Via SIRT1/FOXO1 Pathway in Mice.

Dong Li1, Haipeng Liang1, Yuan Li1, Jianhui Zhang1, Liang Qiao1, Huayun Luo2.   

Abstract

The aim of this study was to investigate the effects of allicin on lead-induced bone loss in mice. Male C57BL/6 J mice (3-weeks-old) were randomly divided into four groups: control group, lead group, allicin+lead group, and allicin group. Micro-CT, histology, oxidative stress, and osteoclastogenesis-related gene expression were analyzed. The results showed that allicin significantly ameliorated lead-induced bone loss, reduced oxidative stress, and inhibited osteoclastogenesis in mice. Moreover, we found that allicin upregulated the expression of SIRT1 and deacetylation of FoxO1. In conclusion, our study demonstrated that allicin exerts protective effects on lead-induced bone loss via antioxidant activity, preventing osteoclastogenesis, and activating SIRT1/FOXO1 pathway in mice, implying a potential therapy for lead-induced bone loss.

Entities:  

Keywords:  Allicin; Bone; Lead; SIRT1/FOXO1

Mesh：

Substances：

Year:  2020        PMID： 32314144     DOI： 10.1007/s12011-020-02136-5

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  31 in total

1.  The effect of lead on bone mineral properties from female adult C57/BL6 mice.

Authors:  A U Monir; C M Gundberg; S E Yagerman; M C H van der Meulen; W C Budell; A L Boskey; T L Dowd
Journal:  Bone       Date:  2010-07-17       Impact factor: 4.398

2.  Elevated Lifetime Lead Exposure Impedes Osteoclast Activity and Produces an Increase in Bone Mass in Adolescent Mice.

Authors:  Eric E Beier; Jonathan D Holz; Tzong-Jen Sheu; J Edward Puzas
Journal:  Toxicol Sci       Date:  2015-10-30       Impact factor: 4.849

3.  Effects of lead and cadmium co-exposure on bone mineral density in a Chinese population.

Authors:  Xiao Chen; Keyue Wang; Zhongqiu Wang; Caohui Gan; Ping He; Yihuai Liang; Taiyi Jin; Guoying Zhu
Journal:  Bone       Date:  2014-03-04       Impact factor: 4.398

4.  Effects of lead, mercury, aluminium and manganese co-exposure on the serum BDNF concentration of pre-school children in Taizhou, China.

Authors:  Can-Can Zhou; Zhen-Yan Gao; Yu-Qiong He; Mei-Qin Wu; Fei Chen; Ju Wang; Jun-Xia Liu; Chong-Huai Yan
Journal:  Chemosphere       Date:  2018-11-03       Impact factor: 7.086

Review 5.  Metal-bone interactions.

Authors:  M Berglund; A Akesson; P Bjellerup; M Vahter
Journal:  Toxicol Lett       Date:  2000-03-15       Impact factor: 4.372

6.  Lead exposure induces Alzheimers's disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain.

Authors:  Can-Can Zhou; Zhen-Yan Gao; Ju Wang; Mei-Qin Wu; Shuang Hu; Fei Chen; Jun-Xia Liu; Hui Pan; Chong-Huai Yan
Journal:  Toxicol Lett       Date:  2018-06-15       Impact factor: 4.372

7.  Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling.

Authors:  James R Edwards; Daniel S Perrien; Nicole Fleming; Jeffry S Nyman; Koichiro Ono; Linda Connelly; Megan M Moore; Seint T Lwin; Fiona E Yull; Gregory R Mundy; Florent Elefteriou
Journal:  J Bone Miner Res       Date:  2013-04       Impact factor: 6.741

8.  Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling.

Authors:  Eric E Beier; Jason R Maher; Tzong-Jen Sheu; Deborah A Cory-Slechta; Andrew J Berger; Michael J Zuscik; J Edward Puzas
Journal:  Environ Health Perspect       Date:  2012-10-19       Impact factor: 9.031

9.  Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels.

Authors:  Claire de Burbure; Jean-Pierre Buchet; Ariane Leroyer; Catherine Nisse; Jean-Marie Haguenoer; Antonio Mutti; Zdenek Smerhovsky; Miroslav Cikrt; Malgorzata Trzcinka-Ochocka; Grazyna Razniewska; Marek Jakubowski; Alfred Bernard
Journal:  Environ Health Perspect       Date:  2006-04       Impact factor: 9.031

10.  Associations of bone mineral density and lead levels in blood, tibia, and patella in urban-dwelling women.

Authors:  Keson Theppeang; Thomas A Glass; Karen Bandeen-Roche; Andrew C Todd; Charles A Rohde; Jonathan M Links; Brian S Schwartz
Journal:  Environ Health Perspect       Date:  2008-06       Impact factor: 9.031
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  3 in total

1.  Sodium Para-aminosalicylic Acid Inhibits Lead-Induced Neuroinflammation in Brain Cortex of Rats by Modulating SIRT1/HMGB1/NF-κB Pathway.

Authors:  Yue-Song Zhao; Jun-Yan Li; Zhao-Cong Li; Lei-Lei Wang; Cui-Liu Gan; Jing Chen; Si-Yang Jiang; Michael Aschner; Shi-Yan Ou; Yue-Ming Jiang
Journal:  Neurochem Res       Date:  2022-09-05       Impact factor: 4.414

Review 2.  Sirtuins as molecular targets, mediators, and protective agents in metal-induced toxicity.

Authors:  Alexey A Tinkov; Michael Aschner; Thuy T Nguyen; Abel Santamaria; Aaron B Bowman; Aleksandra Buha Djordjevic; Monica Maria Bastos Paoliello; Anatoly V Skalny
Journal:  Arch Toxicol       Date:  2021-05-24       Impact factor: 5.153

Review 3.  Dietary organosulfur compounds: Emerging players in the regulation of bone homeostasis by plant-derived molecules.

Authors:  Laura Gambari; Brunella Grigolo; Francesco Grassi
Journal:  Front Endocrinol (Lausanne)       Date:  2022-09-15       Impact factor: 6.055
  3 in total

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