Priya Sekar1, Angie C Jelin2, Christina J Ge3, Amanda C Mahle2, Irina Burd2, Eric B Jelin4. 1. Department of Pediatric Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA. 2. Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD, USA. 3. Wayne State University School of Medicine, Detroit, MI, USA. 4. Department of Pediatric Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Abstract
OBJECTIVE: To evaluate delivery management and outcomes in fetuses prenatally diagnosed with CHD. STUDY DESIGN: A retrospective cohort study was conducted on 6194 fetuses (born between 2013 and 2016), comparing prenatally diagnosed with CHD (170) to those with non-cardiac (234) and no anomalies (5790). Primary outcomes included the incidence of preterm delivery and mode of delivery. RESULTS: Gestational age at delivery was significantly lower between the CHD and non-anomalous cohorts (38.6 and 39.1 weeks, respectively). Neonates with CHD had a significantly lower birth weights (p < 0.001). There was an approximately 1.5-fold increase in the rate of primary cesarean sections associated with prenatally diagnosed CHD with an odds ratio of 1.49 (95% CI 1.06-2.10). CONCLUSIONS: Our study provides additional evidence that the prenatal diagnosis of CHD is associated with a lower birth weight, preterm delivery, and with an increased risk of delivery by primary cesarean section.
OBJECTIVE: To evaluate delivery management and outcomes in fetuses prenatally diagnosed with CHD. STUDY DESIGN: A retrospective cohort study was conducted on 6194 fetuses (born between 2013 and 2016), comparing prenatally diagnosed with CHD (170) to those with non-cardiac (234) and no anomalies (5790). Primary outcomes included the incidence of preterm delivery and mode of delivery. RESULTS: Gestational age at delivery was significantly lower between the CHD and non-anomalous cohorts (38.6 and 39.1 weeks, respectively). Neonates with CHD had a significantly lower birth weights (p < 0.001). There was an approximately 1.5-fold increase in the rate of primary cesarean sections associated with prenatally diagnosed CHD with an odds ratio of 1.49 (95% CI 1.06-2.10). CONCLUSIONS: Our study provides additional evidence that the prenatal diagnosis of CHD is associated with a lower birth weight, preterm delivery, and with an increased risk of delivery by primary cesarean section.
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