OBJECTIVE: To assess the prevalence, timing of diagnosis and infant mortality of congenital heart defects (CHD) with population-based data and using a classification that allows regrouping of the International Paediatric and Congenital Cardiac Code into a manageable number of categories based on anatomic and clinical criteria (ACC-CHD). DESIGN: Population-based cohort study. SETTING: Greater Paris. PATIENTS: All cases (live births, terminations of pregnancy for foetal anomaly (TOPFA), foetal deaths) diagnosed prenatally, or up to 1 year of age in the birth cohorts, May 2005-April 2008, for women in Greater Paris (n=317 538 births). Diagnoses were confirmed in specialised centres and subsequently coded and classified into the categories of ACC-CHD by paediatric cardiologists in the study group. RESULTS: The total number of CHD was 2867, including 2348 live births (82%), 466 TOPFA (16.2%) and 53 foetal deaths (1.8%). The total prevalence of CHD was 90 per 10 000. After exclusion of ventricular septal defects (VSD), 40% of 'isolated' CHD was diagnosed prenatally with about one half of the remaining diagnosed before 7 days of age. Nevertheless, one in five cases of these major CHD was diagnosed after the fourth week. Infant mortality of 'isolated' CHD-VSD excluded was 8.5% with 40% of deaths occurring after the fourth week of life. These outcomes varied substantially across categories of ACC-CHD. CONCLUSIONS: Timing of diagnosis, TOPFA, risk and timing of infant mortality were highly variable across the categories of CHD in ACC-CHD, suggesting that it may be a useful measure of severity, and hence, predictor of outcomes of CHD.
OBJECTIVE: To assess the prevalence, timing of diagnosis and infant mortality of congenital heart defects (CHD) with population-based data and using a classification that allows regrouping of the International Paediatric and Congenital Cardiac Code into a manageable number of categories based on anatomic and clinical criteria (ACC-CHD). DESIGN: Population-based cohort study. SETTING: Greater Paris. PATIENTS: All cases (live births, terminations of pregnancy for foetal anomaly (TOPFA), foetal deaths) diagnosed prenatally, or up to 1 year of age in the birth cohorts, May 2005-April 2008, for women in Greater Paris (n=317 538 births). Diagnoses were confirmed in specialised centres and subsequently coded and classified into the categories of ACC-CHD by paediatric cardiologists in the study group. RESULTS: The total number of CHD was 2867, including 2348 live births (82%), 466 TOPFA (16.2%) and 53 foetal deaths (1.8%). The total prevalence of CHD was 90 per 10 000. After exclusion of ventricular septal defects (VSD), 40% of 'isolated' CHD was diagnosed prenatally with about one half of the remaining diagnosed before 7 days of age. Nevertheless, one in five cases of these major CHD was diagnosed after the fourth week. Infant mortality of 'isolated' CHD-VSD excluded was 8.5% with 40% of deaths occurring after the fourth week of life. These outcomes varied substantially across categories of ACC-CHD. CONCLUSIONS: Timing of diagnosis, TOPFA, risk and timing of infant mortality were highly variable across the categories of CHD in ACC-CHD, suggesting that it may be a useful measure of severity, and hence, predictor of outcomes of CHD.
Authors: Franklin Pereira; Alejandra Bueno; Andrea Rodriguez; Douglas Perrin; Gerald Marx; Michael Cardinale; Ivan Salgo; Pedro Del Nido Journal: J Med Imaging (Bellingham) Date: 2017-01-24
Authors: I Durand; G Deverriere; C Thill; A S Lety; C Parrod; N David; E Barre; T Hazelzet Journal: Pediatr Cardiol Date: 2015-04-07 Impact factor: 1.655
Authors: Angela E Lin; Sergey Krikov; Tiffany Riehle-Colarusso; Jaime L Frías; John Belmont; Marlene Anderka; Tal Geva; Kelly D Getz; Lorenzo D Botto Journal: Am J Med Genet A Date: 2014-08-06 Impact factor: 2.802
Authors: Cora Peterson; April Dawson; Scott D Grosse; Tiffany Riehle-Colarusso; Richard S Olney; Jean Paul Tanner; Russell S Kirby; Jane A Correia; Sharon M Watkins; Cynthia H Cassell Journal: Birth Defects Res A Clin Mol Teratol Date: 2013-09-02