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Literature DB >> 32303281

The Utility of Human Kidney Organoids in Modeling Kidney Disease.

Aneta Przepiorski¹, Amanda E Crunk², Eugenel B Espiritu², Neil A Hukriede³, Alan J Davidson⁴.

Abstract

The formation of three-dimensional kidney tissue (organoids) from human pluripotent stem cell lines provides a valuable tool to examine kidney function in an in vitro model and could be used for regenerative medicine approaches. Kidney organoids have the potential to model kidney diseases and congenital defects, be used for drug development, and to further our understanding of acute kidney injury, fibrosis, and chronic kidney disease. In this review, we examine the current stage of pluripotent stem cell-derived kidney organoid technology, challenges, shortcomings, and regenerative potential of kidney organoids in the future.

Entities: Chemical

Keywords: Kidney organoids; kidney disease; pluripotent stem cells

Mesh：

Year: 2020 PMID： 32303281 PMCID： PMC9003567 DOI： 10.1016/j.semnephrol.2020.01.009

Source DB: PubMed Journal: Semin Nephrol ISSN： 0270-9295 Impact factor: 5.299

89 in total

1. Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.

Authors: Thomas A Forbes; Sara E Howden; Kynan Lawlor; Belinda Phipson; Jovana Maksimovic; Lorna Hale; Sean Wilson; Catherine Quinlan; Gladys Ho; Katherine Holman; Bruce Bennetts; Joanna Crawford; Peter Trnka; Alicia Oshlack; Chirag Patel; Andrew Mallett; Cas Simons; Melissa H Little
Journal: Am J Hum Genet Date: 2018-04-26 Impact factor: 11.025

2. Structure of the human PKD1-PKD2 complex.

Authors: Qiang Su; Feizhuo Hu; Xiaofei Ge; Jianlin Lei; Shengqiang Yu; Tingliang Wang; Qiang Zhou; Changlin Mei; Yigong Shi
Journal: Science Date: 2018-08-09 Impact factor: 47.728

Review 3. Induction of nephron progenitors and glomeruli from human pluripotent stem cells.

Authors: Ryuichi Nishinakamura; Sazia Sharmin; Atsuhiro Taguchi
Journal: Pediatr Nephrol Date: 2016-02-11 Impact factor: 3.714

4. Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network.

Authors: Jian Hui Low; Pin Li; Elaine Guo Yan Chew; Bingrui Zhou; Keiichiro Suzuki; Tian Zhang; Michelle Mulan Lian; Meng Liu; Emi Aizawa; Concepcion Rodriguez Esteban; Kylie Su Mei Yong; Qingfeng Chen; Josep M Campistol; Mingliang Fang; Chiea Chuen Khor; Jia Nee Foo; Juan Carlos Izpisua Belmonte; Yun Xia
Journal: Cell Stem Cell Date: 2019-07-11 Impact factor: 24.633

Review 5. Polycystic Kidney Disease.

Authors: Joseph Ghata; Benjamin D Cowley
Journal: Compr Physiol Date: 2017-06-18 Impact factor: 9.090

6. Generation of functional human pancreatic β cells in vitro.

Authors: Felicia W Pagliuca; Jeffrey R Millman; Mads Gürtler; Michael Segel; Alana Van Dervort; Jennifer Hyoje Ryu; Quinn P Peterson; Dale Greiner; Douglas A Melton
Journal: Cell Date: 2014-10-09 Impact factor: 41.582

7. Evaluation of variability in human kidney organoids.

Authors: Belinda Phipson; Pei X Er; Alexander N Combes; Thomas A Forbes; Sara E Howden; Luke Zappia; Hsan-Jan Yen; Kynan T Lawlor; Lorna J Hale; Jane Sun; Ernst Wolvetang; Minoru Takasato; Alicia Oshlack; Melissa H Little
Journal: Nat Methods Date: 2018-12-20 Impact factor: 28.547

8. Manipulation of Nephron-Patterning Signals Enables Selective Induction of Podocytes from Human Pluripotent Stem Cells.

Authors: Yasuhiro Yoshimura; Atsuhiro Taguchi; Shunsuke Tanigawa; Junji Yatsuda; Tomomi Kamba; Satoru Takahashi; Hidetake Kurihara; Masashi Mukoyama; Ryuichi Nishinakamura
Journal: J Am Soc Nephrol Date: 2019-01-11 Impact factor: 10.121

9. Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells.

Authors: Santhosh V Kumar; Pei X Er; Kynan T Lawlor; Ali Motazedian; Michelle Scurr; Irene Ghobrial; Alexander N Combes; Luke Zappia; Alicia Oshlack; Edouard G Stanley; Melissa H Little
Journal: Development Date: 2019-03-07 Impact factor: 6.868

10. Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease.

Authors: Nelly M Cruz; Xuewen Song; Stefan M Czerniecki; Ramila E Gulieva; Angela J Churchill; Yong Kyun Kim; Kosuke Winston; Linh M Tran; Marco A Diaz; Hongxia Fu; Laura S Finn; York Pei; Jonathan Himmelfarb; Benjamin S Freedman
Journal: Nat Mater Date: 2017-10-02 Impact factor: 43.841

3 in total

Review 1. Experimental models of acute kidney injury for translational research.

Authors: Neil A Hukriede; Danielle E Soranno; Veronika Sander; Tayla Perreau; Michelle C Starr; Peter S T Yuen; Leah J Siskind; Michael P Hutchens; Alan J Davidson; David M Burmeister; Sarah Faubel; Mark P de Caestecker
Journal: Nat Rev Nephrol Date: 2022-02-16 Impact factor: 42.439

2. Modeling oxidative injury response in human kidney organoids.

Authors: Aneta Przepiorski; Thitinee Vanichapol; Eugenel B Espiritu; Amanda E Crunk; Emily Parasky; Michael D McDaniels; Dave R Emlet; Ryan Salisbury; Cassandra L Happ; Lawrence A Vernetti; Matthew L MacDonald; John A Kellum; Thomas R Kleyman; Catherine J Baty; Alan J Davidson; Neil A Hukriede
Journal: Stem Cell Res Ther Date: 2022-02-21 Impact factor: 6.832

Review 3. Advancement of Organoid Technology in Regenerative Medicine.

Authors: Babak Arjmand; Zahra Rabbani; Faezeh Soveyzi; Akram Tayanloo-Beik; Mostafa Rezaei-Tavirani; Mahmood Biglar; Hossein Adibi; Bagher Larijani
Journal: Regen Eng Transl Med Date: 2022-08-08

3 in total