Atsushi Kagimoto1, Yasuhiro Tsutani1, Yu Izaki1, Yoshinori Handa1, Takahiro Mimae1, Yoshihiro Miyata1, Morihito Okada2. 1. Hiroshima University Hospital, Department of Surgical oncology, 1-2-3, Kasumi, Hiroshima city, Hiroshima, 734-8551, Japan. 2. Hiroshima University Hospital, Department of Surgical oncology, 1-2-3, Kasumi, Hiroshima city, Hiroshima, 734-8551, Japan. Electronic address: morihito@hiroshima-u.ac.jp.
Abstract
BACKGROUND: This study aimed to investigate the efficacy of the Deauville criteria, a 5-point semiquantitative scale criteria to assess the maximum standardized uptake value (SUVmax) of [18F]-fluoro-2-deoxy-D-glucose (FDG) on positron emission tomography (PET)/computed tomography (CT), in predicting lymph node metastasis and other pathological invasive characteristics of early-stage lung adenocarcinoma. METHODS: In this retrospective study including 453 patients undergoing lobectomy or segmentectomy with lymph node dissection for clinical T1 or Tis N0 adenocarcinoma between April 2011 and March 2019, the FDG-PET/CT scans were evaluated using the Deauville criteria to analyze the relationship of Deauville score with the clinicopathological characteristics and prognosis. RESULTS: The lymph node metastases were present in 0 (0%), 2 (1.1%), 6 (9.5%), 6 (15.8%), and 13 (15.7%) patients with Deauville scores of 1, 2, 3, 4 and 5, respectively. The pathological invasive characteristics (lymphatic, vascular, or visceral pleural invasion) were detected in 2 (2.4%), 17 (9.9%), 18 (28.6%), 23 (60.5%), and 54 (65.1%) patients with Deauville score 1, 2, 3, 4, and 5, respectively. The 3-year recurrence-free survival was longer in the patients with a Deauville score of 1-2 (97.2%) than those with a Deauville score of 3 (86.2%, p < 0.001) or 4-5 (80.7%, p < 0.001). CONCLUSIONS: The 5-point-scale evaluation of the SUVmax on FDG-PET/CT using the Deauville score was useful in predicting not only lymph node metastasis but also other malignant features of early-stage lung adenocarcinoma.
BACKGROUND: This study aimed to investigate the efficacy of the Deauville criteria, a 5-point semiquantitative scale criteria to assess the maximum standardized uptake value (SUVmax) of [18F]-fluoro-2-deoxy-D-glucose (FDG) on positron emission tomography (PET)/computed tomography (CT), in predicting lymph node metastasis and other pathological invasive characteristics of early-stage lung adenocarcinoma. METHODS: In this retrospective study including 453 patients undergoing lobectomy or segmentectomy with lymph node dissection for clinical T1 or Tis N0 adenocarcinoma between April 2011 and March 2019, the FDG-PET/CT scans were evaluated using the Deauville criteria to analyze the relationship of Deauville score with the clinicopathological characteristics and prognosis. RESULTS: The lymph node metastases were present in 0 (0%), 2 (1.1%), 6 (9.5%), 6 (15.8%), and 13 (15.7%) patients with Deauville scores of 1, 2, 3, 4 and 5, respectively. The pathological invasive characteristics (lymphatic, vascular, or visceral pleural invasion) were detected in 2 (2.4%), 17 (9.9%), 18 (28.6%), 23 (60.5%), and 54 (65.1%) patients with Deauville score 1, 2, 3, 4, and 5, respectively. The 3-year recurrence-free survival was longer in the patients with a Deauville score of 1-2 (97.2%) than those with a Deauville score of 3 (86.2%, p < 0.001) or 4-5 (80.7%, p < 0.001). CONCLUSIONS: The 5-point-scale evaluation of the SUVmax on FDG-PET/CT using the Deauville score was useful in predicting not only lymph node metastasis but also other malignant features of early-stage lung adenocarcinoma.