Current Situation of the Challenging Scale-Up Development of Hydroxymethylfurfural Production.

Hydroxymethylfurfural (HMF) is a high-value platform chemical derived from renewable resources. In recent years, considerable efforts have been made to produce HMF also at industrial scale, which still faces some challenges regarding yield as well as sustainable and economic process designs. This critical Review evaluates the industrial process development of sustainable biomass conversion to HMF. Qualitative and quantitative guidelines are defined for the technological assessment of the processes described in patent literature. The formation of side products, difficulties in the separation and purification of HMF as well as catalyst regeneration were identified as major challenges in the HMF production. A first small-scale, commercial HMF production plant with a capacity of 300 tHMF per year has been operating in Switzerland since 2014.