Literature DB >> 32292548

Evaluation of Pan-SSTRs Targeted Radioligand [64Cu]NOTA-PA1 Using Micro-PET Imaging in Xenografted Mice.

Fei Liu1,2, Xiaoyi Guo2, Teli Liu2, Xiaoxia Xu2, Nan Li2, Chiyi Xiong3, Chun Li3, Hua Zhu2, Zhi Yang2.   

Abstract

64Cu-labeled new pan-somatostatin receptors (pan-SSTRs) probe PA1 was synthesized, characterized, and evaluated by in vitro and in vivo experiments. [64Cu]NOTA-PA1 was obtained with high specific activity, high radiochemical purity, and good stability. Cell uptake of [64Cu]NOTA-PA1 was higher than that of [64Cu]DOTA-TATE in MCF-7, A549, BGC823, and HT-29 cell lines. [64Cu]NOTA-PA1 showed high binding affinity for SSTRs expressed in A549 cells. The in vivo biodistribution and micropositron emission tomography (micro-PET) imaging studies of [64Cu]NOTA-PA1 revealed good detection ability in MCF-7 and A549 xenografted nude mice. The radiosynthesis, quality control, and preliminary biological evaluation of [64Cu]NOTA-PA1 have broaden the application of radiolabeled octreotide for SSTRs imaging, which could act as a potential multisubtypes targeted radiotracer for imaging SSTRs-positive tumors.
Copyright © 2020 American Chemical Society.

Entities:  

Year:  2020        PMID： 32292548      PMCID： PMC7153030          DOI： 10.1021/acsmedchemlett.9b00544

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  24 in total

Review 1.  Pasireotide (SOM230): development, mechanism of action and potential applications.

Authors:  Herbert A Schmid
Journal:  Mol Cell Endocrinol       Date:  2007-09-19       Impact factor: 4.102

2.  The new truncated somatostatin receptor variant sst5TMD4 is associated to poor prognosis in breast cancer and increases malignancy in MCF-7 cells.

Authors:  M Durán-Prado; M D Gahete; M Hergueta-Redondo; A J Martínez-Fuentes; J Córdoba-Chacón; J Palacios; F Gracia-Navarro; G Moreno-Bueno; M M Malagón; R M Luque; J P Castaño
Journal:  Oncogene       Date:  2011-09-19       Impact factor: 9.867

3.  Somatostatin receptors in primary human breast cancer: quantitative analysis of mRNA for subtypes 1--5 and correlation with receptor protein expression and tumor pathology.

Authors:  U Kumar; S I Grigorakis; H L Watt; R Sasi; L Snell; P Watson; S Chaudhari
Journal:  Breast Cancer Res Treat       Date:  2005-07       Impact factor: 4.872

Review 4.  Somatostatin analogues in acromegaly and gastroenteropancreatic neuroendocrine tumours: past, present and future.

Authors:  Kjell Öberg; Steven W J Lamberts
Journal:  Endocr Relat Cancer       Date:  2016-10-03       Impact factor: 5.678

5.  Correlation between Vascular Endothelial Growth Factor and Somatostatin Receptor with Progression and Prognosis in Gastric Cancer.

Authors:  Deng-Qiu Zhao; Jun Chen; Ye-Feng Wu; Dan Tian; Rong-Xiang Zhou
Journal:  Hepatogastroenterology       Date:  2014-06

6.  Highly favourable outcomes with peptide receptor radionuclide therapy (PRRT) for metastatic rectal neuroendocrine neoplasia (NEN).

Authors:  Grace Kong; Simona Grozinsky-Glasberg; Michael S Hofman; Tim Akhurst; Amichay Meirovitz; Ofra Maimon; Yodphat Krausz; Jeremy Godefroy; Michael Michael; David J Gross; Rodney J Hicks
Journal:  Eur J Nucl Med Mol Imaging       Date:  2018-10-20       Impact factor: 9.236

7.  [64Cu-NOTA-8-Aoc-BBN(7-14)NH2] targeting vector for positron-emission tomography imaging of gastrin-releasing peptide receptor-expressing tissues.

Authors:  Adam F Prasanphanich; Prasant K Nanda; Tammy L Rold; Lixin Ma; Michael R Lewis; Jered C Garrison; Timothy J Hoffman; Gary L Sieckman; Said D Figueroa; Charles J Smith
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-12       Impact factor: 11.205

8.  Promising bifunctional chelators for copper 64-PET imaging: practical (64)Cu radiolabeling and high in vitro and in vivo complex stability.

Authors:  Ningjie Wu; Chi Soo Kang; Inseok Sin; Siyuan Ren; Dijie Liu; Varyanna C Ruthengael; Michael R Lewis; Hyun-Soon Chong
Journal:  J Biol Inorg Chem       Date:  2015-12-14       Impact factor: 3.358

9.  In vivo evaluation and small-animal PET/CT of a prostate cancer mouse model using 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systems.

Authors:  Jered C Garrison; Tammy L Rold; Gary L Sieckman; Said Daibes Figueroa; Wynn A Volkert; Silvia S Jurisson; Timothy J Hoffman
Journal:  J Nucl Med       Date:  2007-07-13       Impact factor: 10.057

10.  Deep Learning to Improve Breast Cancer Detection on Screening Mammography.

Authors:  Li Shen; Laurie R Margolies; Joseph H Rothstein; Eugene Fluder; Russell McBride; Weiva Sieh
Journal:  Sci Rep       Date:  2019-08-29       Impact factor: 4.996
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  1 in total

1.  Targeted paclitaxel-octreotide conjugates inhibited the growth of paclitaxel-resistant human non-small cell lung cancer A549 cells in vitro.

Authors:  Yanguo Liu; Handai Xia; Yawei Wang; Wenfei Han; Jing Qin; Wenjuan Gao; Xun Qu; Xiuwen Wang
Journal:  Thorac Cancer       Date:  2021-10-06       Impact factor: 3.500
  1 in total

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